Results 71 to 80 of about 216,058 (206)
Aging Cell, EarlyView.Injury then recovery markedly rewires the DNA methylome in aged skeletal muscle.The addition of senolytics during muscle regeneration decelerates DNAmAGE more than regeneration alone as well as targets collagen remodeling and stem cell function‐related genes.
Toby L. Chambers +16 more
wiley +1 more source
Feedback regulation of VISTA and Treg by TNF‐α controls T cell responses in drug allergy
Allergy, EarlyView.TNF‐α breaks immune tolerance by regulating the VISTA at early stage of the drug‐specific T‐cell response. The response of drug‐responsive effector T cells was negative feedback regulated by increasing Treg cells. This indicates that Treg agonists, rather than TNF‐α antagonists, could be used to treat patients with progressive SCARs.
Lele Sun +14 more
wiley +1 more source
Most Probable Evolution Trajectories in a Genetic Regulatory System Excited by Stable Lévy Noise [PDF]
arXiv, 2018 We study the most probable trajectories of the concentration evolution for the transcription factor activator in a genetic regulation system, with non-Gaussian stable L\'evy noise in the synthesis reaction rate taking into account. We calculate the most probable trajectory by spatially maximizing the probability density of the system path, i.e., the ...
arxiv
Chromosomal Duplication Involving the Forkhead Transcription Factor Gene FOXC1 Causes Iris Hypoplasia and Glaucoma [PDF]
, 2000 Ordan J. Lehmann +11 more
openalex +1 more source
Allergy, EarlyView.Abbreviations: BLOC1S1, biogenesis of lysosome organelles complex 1 subunit 1; cGAS, cyclic GMP‐AMP synthase; GATA3, GATA binding protein 3; IgE, immunoglobulin E; IKK, inhibitor of nuclear factor kappa‐B kinase; IL, interleukin; mtDNA, mitochondrial DNA; NF‐κB, nuclear factor‐kappa B; OVA, ovalbumin; MC903, vitamin D3 analog; STING, stimulator of ...
Rahul Sharma +8 more
wiley +1 more source
Forkhead/winged-helix transcription factor whn regulates hair keratin gene expression: Molecular analysis of theNude skin phenotype [PDF]
, 2000 Thomas Schlake +4 more
openalex +1 more source
Allergy, EarlyView.Screening of 250 natural products identified ginsenoside Rb1 (gRb1) as a potent modulator of regulatory T cells (Tregs) and inflammatory T cells. gRb1 increased IL‐10‐ and TGF‐β‐expressing Tregs while reducing Th17, Th1, and Th2 populations in both asthma model mice and human PBMCs.
Susanna Choi +14 more
wiley +1 more source
Insulin Inhibits the Activation of Transcription by a C-terminal Fragment of the Forkhead Transcription Factor FKHR [PDF]
, 2000 M. Tomizawa +5 more
openalex +1 more source
British Journal of Pharmacology, EarlyView.Abstract Background and Purpose Immune checkpoint inhibitors, such as antiPD1, revolutionized melanoma treatment. However, resistance and low response rates remain problems. Our goal was to pinpoint actionable biomarkers of resistance to anti‐PD1 treatment and verify therapeutic effectiveness in vivo.
Szonja Anna Kovács +13 more
wiley +1 more source
Cell Proliferation, EarlyView.During hypoxia, the transcriptional effect of super‐enhancer in promoting CBP/p300‐interacting transactivator with Glu/Asp‐rich C‐terminal domain, 2 reduced, eventually leading to the thickening of the smooth muscle layer of the pulmonary artery.
Songyue Li +11 more
wiley +1 more source