Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
Star formation rates and the kinematics of gas in the spiral arms of NGC 628
Relations between star formation rates along the spiral arms and the velocities of gas inflow into the arms in grand-design galaxy NGC 628 were studied.
Efremov, Yury N. +2 more
core +1 more source
Variability and star formation in Leo T, the lowest luminosity star-forming galaxy known today [PDF]
We present results from the first combined study of variable stars and star formation history (SFH) of the Milky Way (MW) "ultra-faint" dwarf (UFD) galaxy Leo T, based on F606W and F814W multi-epoch archive observations obtained with the Wide Field ...
Barning +62 more
core +2 more sources
Mechanisms of parasite‐mediated disruption of brain vessels
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira +3 more
wiley +1 more source
The newfound relationship between extrachromosomal DNAs and excised signal circles
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
La formation professionnelle à distance à la lumière des organisations capacitantes
Professional training is concerned by the digitalization of enterprises, a process which refers to the massive use of new technologies. After the popularity of e-learning, the environments inspired by the academic MOOC (COOC, SPOC etc.) appeared to many ...
Anca Boboc, Jean-Luc Metzger
doaj +1 more source
In one-channel, finite-size Luttinger one-dimensional quantum dots, both Friedel oscillations and Wigner correlations induce oscillations in the electron density with the same wavelength, pinned at the same position.
Cavaliere, F. +3 more
core +1 more source
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
Bilan de pratiques évaluatives des apprentissages à distance en contexte de formation universitaire
The development of distance learning in higher education raises the question of the nature and validity of evaluation practices of teachers in a context where the nature of the collected data, the scope and credibility of their interpretation and the ...
Isabelle Nizet +4 more
doaj +1 more source
Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva +10 more
wiley +1 more source

