Results 131 to 140 of about 442,575 (310)

Secteur de formation 15 : mines et travaux de chantier

open access: yes, 2008
Titre de l'écran-titre (visionné le 21 août 2008)"Secteur de formation 15 : mines et travaux de ...
Pouliot, Jean-François   +4 more
core  

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

Formation continue universitaire et sécurisation des parcours

open access: yes, 2015
Journée d'étude organisée par le Centre de recherche en économie de Grenoble (CREG) Les jeudi 5 et vendredi 6 février 2015 à la MSH Alpes Cette journée s'adresse aux chercheurs et acteurs de  la formation tout au long de la vie en Région Rhône-Alpes et ...
Rédaction
core  

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch   +13 more
wiley   +1 more source

Secteur de formation 19 : santé

open access: yes, 2003
Titre de l'écran-titre (visionné le 2 septembre 2008)Version électronique d'un document imprimé publié en 2002"Secteur de formation 19 ...
Fons, Jean-Pierre   +3 more
core  

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

open access: yesMolecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute   +4 more
wiley   +1 more source

L'essor de la formation continue

open access: yes, 2012
Numéro thématique de la Regards sociologiques, n° 41/42, 2011 Sommaire :  Emmanuel de Lescure “[Introduction] De la ‘seconde chance’ à la ‘sécurisation des parcours professionnels’.
Rédaction
core  

Pre-service And In-service Efl Teachers Training Programs In The Light Of Innovation And Change In Language Education

open access: yesThe Journal of Studies in Language, Culture and Society
Pre-service and in-service teacher training programs are changed in the light of innovation in Algerian school. Though ancient and new training programs do not differ from each other in the level of goals, they are different in methods of training ...
Kheira Hadi
doaj  

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Les besoins spécifiques en formation continue des enseignant-e-s en début de carrière

open access: yes
Cet exposé propose des pistes de réflexions sur les besoins spécifiques en formation continue des enseignant-e-s en début de carrière, à la lumière de certains résultats d'une enquête ayant été menée auprès des enseignant-e-s du canton de ...
Paillard, Elodie
core  

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