Results 81 to 90 of about 2,239,947 (297)

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

Identifying Near Earth Object Families

, 2005
The study of asteroid families has provided tremendous insight into the forces that sculpted the main belt and continue to drive the collisional and dynamical evolution of asteroids. The identification of asteroid families within the NEO population could
Benz, Boss, Bottke, Bottke, Bottke, Bottke, Bottke, Cellino, Cellino, Chambers, Daniel D. Durda, Davis, Delbo, dell'Oro, Drummond, Drummond, Drummond, Durda, Durda, Gladman, Hai Fu, Hirayama, James V. Scotti, Jedicke, Jedicke, Jopek, Knežević, Kolmogorov, Leinhardt, Leinhardt, Michel, Morbidelli, Morbidelli, Nesvorný, Nesvorný, Ostro, Raymond, Richardson, Richardson, Robert Jedicke, Ronald Fevig, Smirnov, Southworth, Tanga, Valsecchi, Veeder, von Mises, Zappalà   +47 more
core   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

A qualidade das definições normativas da educação à distância no ensino superior do Brasil

Revista Produção Online, 2003
The text presents in systematic way, in theoretical and reflective character, the qualilative and more excellent aspects, the one that exist in terms of norms and procedures, since the promulgation of the LDB nº 9.394 of 1996 until the moment, that the ...
Solange Coelho de Azevedo, Osvaldo Luis Gonçalves Quelhas   +1 more
doaj  

La formation et l'emploi : nouveaux défis, pour quels changements ? [PDF]

, 1998
L'article montre que les dirigeants de PME-PMI se représentent les actions de formation continue dans un cadre fortement marqué par la théorie économique néo classique de l'offre et de la demande.
Fournet, Michel
core   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

L'impact du programme GENIE sur la qualification des ressources humaines

The Journal of Quality in Education, 2017
La formation continue va de pair avec la qualification des gens ciblés, vu que cette formation est toujours au service de l'organisation et de l'individu lui- même.
Mohamed Khalil Zarhouti, Mohammed Mouradi   +1 more
doaj   +1 more source

La formation continue : est-elle accessible à tous ? [PDF]

Ce mémoire a pour but de montrer les inégalités d'accès à la formation continue en France et d'exposer des solutions pour permettre l'accès à la formation continue au plus grand nombre.
Yoann Allaert
core  

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source