Results 91 to 100 of about 2,251,358 (297)
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
A qualidade das definições normativas da educação à distância no ensino superior do Brasil
Revista Produção Online, 2003 The text presents in systematic way, in theoretical and reflective character, the qualilative and more excellent aspects, the one that exist in terms of norms and procedures, since the promulgation of the LDB nº 9.394 of 1996 until the moment, that the ...
Solange Coelho de Azevedo +1 more
doaj
Chemistry of fuel deposits and sediments and their predursors [PDF]
The mechanism of solid deposit formation on hot engine parts from turbine fuels is investigated. Deposit formation is associated with oxidation of the hydrocarbon fuel.
Buttrill, S. E., Jr. +3 more
core +1 more source
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Indicateurs internationaux relatifs à la formation continue et à l'articulation formation-emploi : application à la Wallonie. Rapport final [PDF]
, 2007 Indicateurs internationaux relatifs à la formation continue et à l'articulation formation-emploi : application à le ...
Baye, Ariane +3 more
core
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
La formation professionnelle continue : de quelques ambiguïtés historiques
La Nouvelle Revue du TravailLa Nouvelle Revue du Travail asked three specialists in continuing professional training to discuss a series of questions linked to the individualization of training, the decline in collective negotiations and the future of training system.
Didier GELOT +2 more
doaj +1 more source