Results 81 to 90 of about 5,378,594 (299)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Formation à distance et activité du stagiaire de la formation professionnelle continue

Éducation et Socialisation, 2014
This paper discusses the practical vocational training in the framework of a hybrid system. This is particularly ask the vocationnal education training as operational content to facilitate the transformation of subjects in action.
Béatrice Verquin-Savarieau
doaj   +1 more source

Soyons créatifs tout au long de la vie ! Manifeste de l’innovation pédagogique

, 2016
Innovation, créativité, flexibilité, prise de risque, etc. Autant de termes anciens, mais qui sont toujours et de plus en plus d’actualité. Les phénomènes d’innovation ne touchent plus uniquement le monde de l’entreprise, mais aussi celui de l ...
Capron Puozzo, Isabelle
core  

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Secteur de formation 4 : arts

, 2004
Titre de l'écran-titre (visionné le 5 septembre 2008)"Secteur de formation 4 ...
Arendasova, Daniela, Québec (Province). Formation professionnelle et technique et formation continue. Direction générale des programmes et du développement   +1 more
core   +1 more source

Perception et Attente des Infirmiers sur la formation continue en soins palliatifs aux Cliniques Universitaires de Kinshasa

Revue des Sciences de la Santé
En République Démocratique du Congo (RDC), malgré les initiatives mises en place pour améliorer l'accès aux soins palliatifs, les établissements médicaux se heurtent à un manque de personnel qualifié, à l'absence de programmes éducatifs systématiques et ...
Emilie MBOLO ZONGA, Samuel BAPIDIA NZENGU, Dominique JACQUEMAN, Jacques LOFANDJOLA MASUMBUKU, Augustin TSHITADI MAKANGU   +4 more
doaj   +1 more source

On the formation of continued fractions

, 2005
17 pages, seems to be first English translation of Euler's Latin original ``De formatione fractionum continuarum'', Acta Academiae Scientarum Imperialis Petropolitinae 3 (1782), no.
openaire   +2 more sources

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Secteur de formation 19 : santé

, 2008
Titre de l'écran-titre (visionné le 21 août 2008)"Secteur de formation 19 ...
Fons, Jean-Pierre, Timmons-Plamondon, Ghislaine, Québec (Province). Formation professionnelle et technique et formation continue. Direction générale de la formation professionnelle et technique, Lecours, Lise, Adan, André   +4 more
core   +2 more sources