Results 101 to 110 of about 442,575 (310)

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

open access: yesFEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara   +3 more
wiley   +1 more source

Secteur de formation 4 : arts

open access: yes, 2004
Titre de l'écran-titre (visionné le 5 septembre 2008)"Secteur de formation 4 ...
Arendasova, Daniela   +1 more
core  

La formation professionnelle continue : de quelques ambiguïtés historiques

open access: yesLa Nouvelle Revue du Travail
La Nouvelle Revue du Travail asked three specialists in continuing professional training to discuss a series of questions linked to the individualization of training, the decline in collective negotiations and the future of training system.
Didier GELOT   +2 more
doaj   +1 more source

Preferred modalities for delivering continuing education to the public health workforce: a scoping review. [PDF]

open access: yesHealth Promot Chronic Dis Prev Can, 2020
Archer A   +4 more
europepmc   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

open access: yesFEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee   +7 more
wiley   +1 more source

Le non-recours à la formation continue en entreprise

open access: yesLa Nouvelle Revue du Travail
This article seeks to show that, although the notion of non-take up was developed in the context of the fight against poverty, it is relevant for understanding the relationship of employees to in-company training. While successive reforms of training law
Emmanuel de Lescure
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

open access: yesFEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar   +4 more
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

open access: yesFEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik   +5 more
wiley   +1 more source

Projet de recherche : la formation continue des journalistes et le digital

open access: yes, 2018
« Mobile learning et micro learning, social learning et adaptative learning, gamification… : quel rôle donner à l'innovation pédagogique digitale dans la formation – initiale, continue – des journalistes ?
Patrick Lenormand
core  

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

open access: yesFEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens   +8 more
wiley   +1 more source

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