Results 101 to 110 of about 159,335 (341)

Influence of Hypoxia on a Biomaterial Model of the Bone Marrow Perivascular Niche

Advanced Healthcare Materials, EarlyView.
Hypoxia is a key factor in bone marrow physiology and hematopoietic stem cell behavior. Lower oxygen tension influences the secretion of vasculature‐derived hematopoietic regulatory factors and alters hematopoietic cell behavior in a conditioned medium hydrogel model of bone marrow. Cyclosporin A is used to mitigate normoxic stress during hematopoietic
Gunnar B. Thompson, Victoria R. Barnhouse, Sydney K. Bierman, Brendan A.C. Harley   +3 more
wiley   +1 more source

Prognostic significance of tumor microenvironment assessed by machine learning algorithm in surgically resected non‐small cell lung cancer

Cancer Reports, EarlyView., 2023
Abstract Background A methodology to assess the immune microenvironment (IME) of non‐small cell lung cancer (NSCLC) has not been established, and the prognostic impact of IME factors is not yet clear. Aims This study aimed to assess the IME factors and evaluate their prognostic values. Methods and Results We assessed CD8+ tumor‐infiltrating lymphocyte (
Yukihiro Terada, Mitsuhiro Isaka, Akira Ono, Takuya Kawata, Masakuni Serizawa, Keita Mori, Koji Muramatsu, Kiyoshi Tone, Hirotsugu Kenmotsu, Keiichi Ohshima, Kenichi Urakami, Takeshi Nagashima, Masatoshi Kusuhara, Yasuto Akiyama, Takashi Sugino, Toshiaki Takahashi, Yasuhisa Ohde   +16 more
wiley   +1 more source

Differential effects of α4β7 and GPR15 on homing of effector and regulatory T cells from patients with UC to the inflamed gut in vivo [PDF]

, 2015
Objective: Gut homing of lymphocytes via adhesion molecules has recently emerged as new target for therapy in inflammatory bowel diseases. We aimed to analyze the in vivo homing of effector (Teff) and regulatory (Treg) T cells to the inflamed gut via ...
Agace, Alastair Watson, Anika Fischer, Atreya, Babyatsky, Baumgart, Canavan, Caroline Voskens, Christoph Becker, Clemens Neufert, Danese, Desreumaux, Dustin, Egawa, Fantini, Feagan, Fuss, Gerlach, Gerold Schuler, Ghosh, Haddad, Hamann, Hesterberg, Hoshino, Imke Atreya, Jovani, Kanai, Kempster, Kim, Ley, Li, Macdonald, Markus F Neurath, Matsuzaki, Maul, Neurath, Neurath, Nguyen, Nourshargh, Oki, Papadakis, Picarella, Podolsky, Pryde, Raja Atreya, Rocío López-Posadas, Rott, Rutgeerts, Sandborn, Sandborn, Sebastian Zundler, Shultz, Simon Hirschmann, Strober, Thomas, Tidswell, Timo Rath, Van Assche, Vermeire, Villablanca, Wang, Weninger, Wirtz, Wyant, Wyant   +64 more
core   +1 more source

Microbiota‐Derived Inosine Suppresses Systemic Autoimmunity via Restriction of B Cell Differentiation and Migration

Advanced Science, EarlyView.
Lactobacillus johnsonii and its associated purine metabolite inosine not only restrict systemic B cell differentiation, but also contribute to immune cell infiltration in the kidneys, thereby serving dual functions in mitigating the progression of systemic lupus erythematosus (SLE).
Lingyu Gao, Yuhan Zhang, Zhi Hu, Shengwen Chen, Qiaolin Wang, Yong Zeng, Huiqi Yin, Junpeng Zhao, Yijing Zhan, Changxing Gao, Yue Xin, Bing Chen, Stijn van der Veen, Ming Zhao, Deyu Fang, Qianjin Lu   +15 more
wiley   +1 more source

Epithelial PD‐L1 expression at tumor front predicts overall survival in a cohort of oral squamous cell carcinomas from Sudan

Clinical and Experimental Dental Research, Volume 8, Issue 6, Page 1467-1477, December 2022., 2022
Abstract Background We recently described the tumor immune microenvironment (TIME) in oral squamous cell carcinomas (OSCC) from Sudan by assessing the core of the lesions. However, the invasive tumor front (ITF) is the most active part of OSCC lesions; thus, TIME should also be characterized at the ITF in this patient cohort.
Nuha M. Gaafar, Tarig Al‐Hadi Osman, Mariam Elsheikh, Israa Abdulrahman Ahmed, Harsh Dongre, Siren Fromreide, Ahmed M. Suleiman, Anne C. Johannessen, Elisabeth S. Nginamau, Daniela‐Elena Costea   +9 more
wiley   +1 more source

Gut Microbiota‐Butyrate‐PPARγ Axis Modulates Adipose Regulatory T Cell Population

Advanced Science, EarlyView.
This study identifies the indispensable role of gut microbiota in the maintenance of ST2+ adipose Treg cell population, and defines gut microbiota‐derived butyrate as an endogenous PPARγ agonist, modulating adipose Treg cell populations via promoting PPARγ activation. Butyrate or fiber supplementation restores the VAT ST2+ Treg population in obese mice
Banru Chen, Lizhi Guan, Chao Wu, Yiwen Gong, Lei Wu, Minchun Zhang, Zhiwen Cao, Yufei Chen, Chengcan Yang, Bing Wang, Yunqi Li, Bin Li, Yufang Bi, Guang Ning, Jiqiu Wang, Weiqing Wang, Ruixin Liu   +16 more
wiley   +1 more source

MicroRNAs regulate T-cell production of interleukin-9 and identify hypoxia-inducible factor-2a as an important regulator of T helper 9 and regularoty T-cell differentiation [PDF]

, 2016
MicroRNAs (miRNAs) regulate many aspects of helper T cell (Th) development and function. Here we found that they are required for the suppression of interleukin‐9 (IL‐9) expression in Th9 cells and other Th subsets. Two highly related miRNAs (miR‐15b and
Baumjohann, Chang, Chong, Clambey, Cobb, Dang, Dardalhon, Elyaman, Filipowicz, Gerlach, Goswami, Goswami, Goswami, Haraguchi, He, Jabeen, Kaelin, Keith, Kohlhaas, Lewis, Licona-Limón, Lu, Lu, Lukashev, McNamee, Muljo, Nakatsukasa, Noelle, Nowak, Pua, Purwar, Schmitt, Shi, Singh, Staudt, Veldhoen, Yao, Zhou   +37 more
core   +1 more source

Immune and Angiogenic Profiling of Mesenchymal Stem Cell Functions in a Subcutaneous Microenvironment for Allogeneic Islet Transplantation

Advanced Science, EarlyView.
With emphasis on a diabetic state, this study highlights the role of mesenchymal stem cells (MSCs) in enhancing vascularization and modulating immune responses within a subcutaneous platform for cell transplantation for type 1 diabetes (T1D). Comprehensive profiling of MSC‐induced angiogenic and immune responses, provides insight into the role of MSCs ...
Jocelyn Nikita Campa‐Carranza, Simone Capuani, Ashley L. Joubert, Nathanael Hernandez, Tommaso Bo, Octavio I. Sauceda‐Villanueva, Marzia Conte, Letizia Franco, Marco Farina, Gabrielle E. Rome, Yitian Xu, Junjun Zheng, Lissenya B. Argueta, Jean A. Niles, Fotis Nikolos, Corrine Ying Xuan Chua, Shu‐Hsia Chen, Joan E. Nichols, Norma S. Kenyon, Alessandro Grattoni   +19 more
wiley   +1 more source

Radioimmunotherapy‐induced intratumoral changes in cervical squamous cell carcinoma at single‐cell resolution

, 2022
Cancer Communications, Volume 42, Issue 12, Page 1407-1411, December 2022.
Chao Liu, Hao Yu, Rui Huang, Tianyu Lei, Xiaohui Li, Ming Liu, Qingyu Huang, Qilian Du, Ligang Xing, Jinming Yu   +9 more
wiley   +1 more source

Paclitaxel/Luteolin Coloaded Dual‐Functional Liposomes for Esophageal Cancer Therapy

Advanced Science, EarlyView.
The authors develop a pH‐sensitive aptamer‐modified liposome (EA2‐PSL‐PTX/LUT) to illustrate a strategy for the precise delivery of combinational chemotherapeutic drugs for esophageal squamous cell carcinoma (ESCC) targeted therapy. EA2‐PSL‐PTX/LUT provides efficient co‐loading, tumor targeting, and controlled release of luteolin and paclitaxel ...
Congyong Sun, Fei Xie, Huiyun Zhang, Lulu Feng, Yuting Wang, Chaofan Huang, Zhizhen Cui, Chao Luo, Li Zhang, Qilong Wang   +9 more
wiley   +1 more source