Results 251 to 260 of about 106,447 (316)

The Immunoregulatory and Hematopoietic Effects of Momelotinib in a Murine Bone Marrow Failure Model

Journal of Clinical Laboratory Analysis, EarlyView.
Momelotinib, a selective small‐molecule inhibitor of JAK1/2 and the bone morphogenic protein receptor kinase activin A receptor type I (ACVR1), exerts its effects by inhibiting the overactivation of the BMP/ACVR1/SMAD signaling pathway. This inhibition reduces hepcidin production in hepatocytes, and reduces inflammation, aberrant cytokine signaling ...
Yue Zhang, Huiqin Zhang, Naibo Hu, Liping Yang, Yumei Liu, Liyan Yang, Xifeng Dong, Huaquan Wang   +7 more
wiley   +1 more source

Promotion of human choroidal melanoma cell metastases by FOXP3 <i>via</i> Wnt5a/CaMKII signaling pathway. [PDF]

Int J Ophthalmol
Yuan YY, Liu YC, Zhang Q, Gao XD, Zhu YZ, Cheng K, Zhao H, Fu WW, Lei K, Sui AH, Luo WJ.   +10 more
europepmc   +1 more source

Immunomodulatory Effects of a New Ethynylpiperidine Derivative: Enhancement of CD4⁺FoxP3⁺ Regulatory T Cells in Experimental Acute Lung Injury. [PDF]

Biomedicines
Balabekova MK, Kairanbayeva GK, Yu VK, Zhumakova S, Li M, Seilkhanov TM, Tassibekov KS, Alimova MA, Mussilim MB, Ramazanova AA.   +9 more
europepmc   +1 more source

Respiratory Syncytial Virus (RSV): A Comprehensive Overview From Basic Biology to Clinical Prevention and Control

Medicinal Research Reviews, EarlyView.
ABSTRACT Respiratory syncytial virus (RSV) is a common virus that causes respiratory infections, posing a serious threat, particularly to infants, the elderly, and individuals with compromised immune systems. As the leading cause of lower respiratory tract infections (LRTIs) in infants, RSV is responsible for millions of cases worldwide each year.
Jie Shi, Xiya Huang, Chunjun Ye, Yishan Lu, Yanyan Liu, Yuquan Wei, Xiawei Wei   +6 more
wiley   +1 more source

Divergent roles of macrophage subsets, FoxP3, and IL-17A in HSV-1-induced CNS pathology. [PDF]

PLoS Pathog
Jaggi U, Hirose S, Wang S, Ghiasi H.
europepmc   +1 more source

Integrating artificial intelligence (AI) into colorectal cancer reporting

The Journal of Pathology, EarlyView.
Abstract Artificial intelligence (AI) and deep learning (DL) are transforming cancer research and clinical care, with histopathology playing a central role in this transformation. In colorectal cancer (CRC), the second leading cause of cancer mortality world‐wide, multimodal and vision‐language models (VLMs) hold particular promise for enhancing the ...
Konstantin Bräutigam, Ann‐Marie Baker, Viktor H Koelzer, Jakob N Kather, Trevor A Graham   +4 more
wiley   +1 more source

Mesenchymal stromal cell therapy for rheumatoid arthritis: Long‐term efficacy, safety, and mechanistic insights

Rheumatology &Autoimmunity, EarlyView.
Graphical abstract summarizing the multifactorial pathogenesis of rheumatoid arthritis (RA) and the therapeutic potential of mesenchymal stromal cell (MSC) therapy. MSCs provide promising benefits through their immunomodulatory properties, low immunogenicity, ability to promote tissue repair, and multi‐lineage differentiation, presenting a potential ...
Yingjia Chen, Ruiyu Gao, Xing Guo, Genhong Yao, Xiaojun Tang, Yile E. Liu, Lingyun Sun   +6 more
wiley   +1 more source

FOXP3 Polymorphism and Upregulation of the CXCL12-CXCR4-SNAIL Axis with High Infiltration of M2TAM by STAT3/NFKB Pathways Influence the Survival of Cervical Cancer Patients. [PDF]

Adv Biol (Weinh)
Lira GA, de Azevedo FM, Lins IGS, Crispim JCO, Lira GA, Cavalcante RS, Cobucci R, Mendes-Aguiar CO, Da Silva RTD, da Silva VE, Aquino RCQ, Araújo Júnior RF.   +11 more
europepmc   +1 more source

Engineering a Tumor‐Targeted MgH2@Lip/PD‐L1 Nanoplatform for Synergistic Hydrogen Therapy and Immune Activation

Rare Metals, EarlyView.
ABSTRACT Lung cancer remains the leading cause of cancer‐related deaths worldwide, yet immune checkpoint blockade (ICB) is often compromised by an immunosuppressive tumor microenvironment (TME) with acidosis, hypoxia, and poor T cell infiltration. Here, we develop a TME‐responsive nanoplatform (MgH2@Lip/PD‐L1) that couples hydrogen gas therapy with PD ...
Xuyu Gu, Ming Deng, Tao Ge, Li Xu, Xinnan Xu, Kaiqi Jin   +5 more
wiley   +1 more source

Crosstalk Between Extracellular Vesicles and Regulatory T Cells Across Cancers: From Interaction to Therapeutic Potential. [PDF]

Int J Nanomedicine
Liu D, Hao Z, He G, Huang Y.
europepmc   +1 more source