Results 251 to 260 of about 171,978 (359)

Oxidative phosphorylation at the crossroads of cancer: Metabolic orchestration, stromal collusion, and emerging therapeutic horizons

Interdisciplinary Medicine, EarlyView.
Although most cancer cells rely on aerobic glycolysis, Oxidative phosphorylation (OXPHOS) remains essential for their survival, proliferation, and metastasis. With the emergence of OXPHOS‐targeted drugs, its therapeutic potential is becoming increasingly evident.
Keke Chen, Bo Wang, Hongying Shu, Jianxin Lyu, Wei Cui, Hezhi Fang   +5 more
wiley   +1 more source

Tumor and immune cell distribution in the tumor core and outer part of glioblastoma, IDH wildtype. [PDF]

J Neurooncol
Pedersen V, Knudsen AM, Michaelsen SR, Dahlrot RH, Kristensen BW.   +4 more
europepmc   +1 more source

FOXP3 Identifies Regulatory CD25^brightCD4⁺ T Cells in Rheumatic Joints [PDF]

, 2006
Duojia Cao, Ola Börjesson, P. Larsson, Anna Rudin, Iva Gunnarsson, Lars Klareskog, Vivianne Malmström, Christina Trollmo   +7 more
openalex   +1 more source

Effects of CRISPR-Cas9-mediated <i>FOXP3</i> knockout on CAR T cell potency. [PDF]

Mol Ther Methods Clin Dev
Peter L, Farrera-Sal M, Yaman FA, Dempewolf NH, Picht S, Schulenberg S, Kath J, Hamm F, Heinrich F, Wagner DL, Mashreghi MF, Künkele A, Reinke P, Polánsky JK, Schmueck-Henneresse M.   +14 more
europepmc   +1 more source

Putting a block on Foxp3 [PDF]

Nature Immunology, 2013
openaire   +2 more sources

The Evolving Landscape of Immunotoxicity: Charting Mechanisms and Future Strategies for Immune Checkpoint Inhibitor Adverse Events

Med Research, EarlyView.
ABSTRACT The use of immune checkpoint inhibitors (ICIs) has significantly improved the efficacy of cancer therapy, but their associated immune‐related adverse events (irAEs) can severely compromise treatment safety. This review systematically summarizes the core mechanisms underlying irAEs, which include multi‐organ damage resulting from T‐cell ...
Anqi Lin, Keyin Zheng, Aimin Jiang, Xufeng Huang, Qi Wang, András Hajdu, Zhengrui Li, Jian Zhang, Peng Luo   +8 more
wiley   +1 more source

Bifidobacterium animalis subsp. Lactis BL‐99 Improves Maternal and Fetal Immune Responses and Pregnancy Outcomes in Pregnant Antibiotics‐Treated Mice

Molecular Nutrition &Food Research, EarlyView.
Pregnant mice treated with antibiotics showed gut dysbiosis, which is associated with reduced fetal and placental weight, and disrupted maternal and fetal immune responses. Supplementation via oral gavage with Bifidobacterium animalis subsp. lactis BL‐99 increased B. animalis levels in the gut, but did not fully restore microbiome balance.
Marijke M. Faas, Lieske Wekema, Carolien A. van Loo‐Bouwman, Gisela A. Weiss, Wei‐lian Hung, Bart J. de Haan, Alexandra M. Smink   +6 more
wiley   +1 more source

GARP-expressing Tregs as a source of immunosuppressive TGF-β1 in human tumors. [PDF]

Cancer Immunol Immunother
Van Meerbeeck P, Maatougui D, de Streel G, Vaherto N, Marbaix E, Aboubakar Nana F, Van den Eynde M, Devaux A, Carrasco J, Noel A, van Baren N, Lucas S.   +11 more
europepmc   +1 more source

Hexanoic Acid Intake Enhances Anti‐Tumor Immune Responses in Colorectal Cancer by Reducing the Immunosuppressive Function of Tregs

Molecular Nutrition &Food Research, EarlyView.
This study found hexanoic acid (HA), a fatty acid in milk, inhibits colorectal cancer by enhancing anti‐tumor immune responses. HA suppresses naïve CD4+ T cell differentiation into Tregs, reduces the immunosuppressive activity of Tregs against CD8+ T cells, and decreases tumor infiltration of Tregs.
Daichi Seta, Kenta Nagahori, Yuki Katoh, Tadashi Ogawa, Takashi Iwata, Hiroshi Nishio, Masaki Sugawara, Yosuke Fujii, Ayano Yoshido, Hiroshi Seno, Shuichi Hirai   +10 more
wiley   +1 more source

Author Correction: Foxp3 + Treg-derived IL-10 promotes colorectal cancer-derived lung metastasis. [PDF]

Sci Rep
Shiri AM, Fard-Aghaie M, Bedke T, Papazoglou ED, Sabihi M, Zazara DE, Zhang S, Lücke J, Seeger P, Evers M, Hackert T, Oldhafer KJ, Gondolesi GE, Huber S, Giannou AD.   +14 more
europepmc   +1 more source