Anti-regulatory T cell vaccines in immunotherapy: focusing on FoxP3 as target
Human Vaccines & Immunotherapeutics, 2019 Anti- tumor vaccination elicits imperfect immune responses against tumor cells; that is related to the presence of suppressive obstacles in the tumor microenvironment.
Neda Mousavi-Niri +2 more
doaj +1 more source
Regulatory T cells in melanoma revisited by a computational clustering of FOXP3+ T cell subpopulations [PDF]
, 2015 CD4+ T cells that express the transcription factor FOXP3 (FOXP3+ T cells) are commonly regarded as immunosuppressive regulatory T cells (Treg). FOXP3+ T cells are reported to be increased in tumour-bearing patients or animals, and considered to suppress ...
Fujii, H +5 more
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FOXP3 and FOXP3-regulated microRNAs suppress SATB1 in breast cancer cells [PDF]
Oncogene, 2011 The transcription factor FOXP3 has been identified as a tumour suppressor in the breast and prostate epithelia, but little is known about its specific mechanism of action. We have identified a feed-forward regulatory loop in which FOXP3 suppresses the expression of the oncogene SATB1. In particular, we demonstrate that SATB1 is not only a direct target
McInnes, N. +8 more
openaire +4 more sources
Expression and DNA methylation of TNF, IFNG and FOXP3 in colorectal cancer and their prognostic significance. [PDF]
, 2014 BACKGROUND: Colorectal cancer (CRC) progression is associated with suppression of host cell-mediated immunity and local immune escape mechanisms. Our aim was to assess the immune function in terms of expression of TNF, IFNG and FOXP3 in CRC. METHODS:
A D Beggs +52 more
core +2 more sources
Depleting T regulatory cells by targeting intracellular Foxp3 with a TCR mimic antibody
OncoImmunology, 2019 Depletion of T regulatory cells (Tregs) in the tumor microenvironment is a promising cancer immunotherapy strategy. Current approaches for depleting Tregs are limited by lack of specificity and concurrent depletion of anti-tumor effector T cells.
Tao Dao +13 more
doaj +1 more source
Репродуктивная эндокринология, 2017 The aim of study. To reveal the peculiarities of mRNA expression of the inflammatory component genes of the immune response in the expected window of the implantation in women with RPL in ART programs. Material and methods.
К. П. Головатюк +4 more
doaj +1 more source
Characterization of human epithelial resident memory regulatory T cells
Frontiers in Immunology, 2022 Human resident memory regulatory T cells (Tregs) exist in the normal, noninflamed skin. Except one, all previous studies analyzed skin Tregs using full-thickness human skin.
Takuya Sato +11 more
doaj +1 more source
The role of Foxp3 and Tbet co-expressing Treg cells in lung carcinoma
OncoImmunology, 2018 Despite the opposite roles of Tbet and Foxp3 in the immune system as well as in tumour biology, recent studies have demonstrated the presence of of CD4+ T cells, expressing both, Tbet and Foxp3.
Katerina Kachler +4 more
doaj +1 more source
Notch and NF-kB: Coach and Players of Regulatory T-Cell Resposnse in Cancer [PDF]
, 2018 The Notch signaling pathway plays multiple roles in driving T-cell fate decisions, proliferation, and aberrant growth. NF-kB is a cell-context key player interconnected with Notch signaling either in physiological or in pathological conditions.
Bellavia, Diana +5 more
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Supporting children with genetic syndromes in the classroom: the example of 22q deletion syndrome [PDF]
, 2013 An increasing number of children are likely to have a known genetic cause for their special educational needs. One such genetic condition is 22q11.2 deletion syndrome (22qDS), a genetic syndrome associated with early speech and language difficulties ...
Reilly, C, Stedman, L
core +1 more source