Results 31 to 40 of about 106,447 (316)

NATURAL REGULATORY T CELLS AND THEIR MOLECULAR MARKER FOXP3 IN FREQUENTLY ILL PRE-SCHOOL CHILDREN LIVING IN AREAS WITH HUMAN-INDUCED IMPACT

Педиатрическая фармакология, 2013
The study presents the review of recent literature on microbial resistance in children suffered from reccurent respiratory infaction (RRI). Special aspects of immune system in children with allergy and acute respiratory infection are discussed. We report
A. D. Pertseva, N. Z. Zokirov, V. V. Troshina, L. S. Namazova-Baranova, S. Y. Tarakanova   +4 more
doaj   +1 more source

Evaluation of the Relationship of PD-L1 and FOXP3 Expressions With Clinicopathological Parameters in Gastric Carcinomas

Forbes Tıp Dergisi, 2021
Objective: At the time of diagnosis, gastric cancers are generally at an advanced stage and the survival rates are very low. The aim of this study is to determine the prognostic values of PD-L1 expression in gastric carcinomas and to detect the presence ...
Sevil Sayhan, Gulden Diniz, Duygu Ayaz, Dudu Solakoglu Kahraman, Pınar Ayvat, Bulent Calik   +5 more
doaj   +1 more source

Anti-regulatory T cell vaccines in immunotherapy: focusing on FoxP3 as target

Human Vaccines & Immunotherapeutics, 2019
Anti- tumor vaccination elicits imperfect immune responses against tumor cells; that is related to the presence of suppressive obstacles in the tumor microenvironment.
Neda Mousavi-Niri, Maryam Naseroleslami, Jamshid Hadjati   +2 more
doaj   +1 more source

Value of Foxp3 expressing T-regulatory cells in renal tissue in lupus nephritis; an immunohistochemical study [PDF]

Journal of Nephropathology, 2016
Background: Forkhead box P3 (Foxp3) functions as a master regulator in the development and function of T-regulatory (Treg) cells. Recent studies have shown that autoimmune diseases including systemic lupus erythematosus (SLE) are associated with an ...
Marwa M Shakweer, Maha Behairy, Nadia G Elhefnawy, Tamer W Elsaid   +3 more
doaj   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Runx proteins regulate Foxp3 expression [PDF]

Journal of Experimental Medicine, 2009
Runx proteins are essential for hematopoiesis and play an important role in T cell development by regulating key target genes, such as CD4 and CD8 as well as lymphokine genes, during the specialization of naive CD4 T cells into distinct T helper subsets.
Bruno, L, Mazzarella, L, Hoogenkamp, M, Hertweck, A, Cobb, BS, Sauer, S, Hadjur, S, Leleu, M, Naoe, Y, Telfer, JC, Bonifer, C, Taniuchi, I, Fisher, AG, Merkenschlager, M   +13 more
openaire   +4 more sources

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Depleting T regulatory cells by targeting intracellular Foxp3 with a TCR mimic antibody

OncoImmunology, 2019
Depletion of T regulatory cells (Tregs) in the tumor microenvironment is a promising cancer immunotherapy strategy. Current approaches for depleting Tregs are limited by lack of specificity and concurrent depletion of anti-tumor effector T cells.
Tao Dao, Sung Soo Mun, Andrew C. Scott, Casey A. Jarvis, Tatyana Korontsvit, Zhiyuan Yang, Lianxing Liu, Martin G. Klatt, Manuel Guerreiro, Annamalai Selvakumar, Elliott J. Brea, Claire Oh, Cheng Liu, David A. Scheinberg   +13 more
doaj   +1 more source

Expression of the mRNA of the inflammatory component of the immune response in the period of the expected window of implantation in women with recurrent pregnancy loss in the programs of assisted reproductive technologies

Репродуктивная эндокринология, 2017
The aim of study. To reveal the peculiarities of mRNA expression of the inflammatory component genes of the immune response in the expected window of the implantation in women with RPL in ART programs. Material and methods.
К. П. Головатюк, В. Г. Дубініна, О. М. Носенко, Е. Т. Макшаєва, І. Л. Головатюк-Юзефпольська   +4 more
doaj   +1 more source

SUBCELLULAR LOCALIZATION OF FoxP3 TRANSCRIPTION FACTOR IN PATIENTS WITH ACUTE CORONARY SYNDROME: COMPARATIVE ANALYSIS AND PROSPECTIVE OBSERVATION

Медицинская иммунология, 2021
The key cellular and molecular factors being involved in the resolution of inflammation following acute myocardial infarction remain poorly understood.
I. V. Kologrivova, Tatiana E. Suslova, V. V. Ryabov, M. A. Shtatolkina, O. A. Koshelskaya, O. A. Trubacheva, E. S. Kravchenko   +6 more
doaj   +1 more source