Results 71 to 80 of about 171,978 (359)

CD₈⁺ AND CD₄⁺ REGULATORY T CELLS IN COLORECTAL CANCER

Transactions of the Karelian Research Centre of the Russian Academy of Sciences, 2020
The pathogenesis of colorectal cancer (CRC) is closely associated with the development of an antitumor immune response. An important role in the regulation of the immune response is given to regulatory T cells (Treg), which may interfere with the ...
Galina Zhulai, Anastasia Novitskaya, Alexei Churov, Alexander Romanov, Kylymbek Mamashov, Anastasia Tonkushina   +5 more
doaj   +1 more source

Key role for inhibins in effective T cell activation, migration and Th17 differentiation

FEBS Open Bio, EarlyView.
Activins/inhibins modulate immune responses. Here, we show that inhibins can be produced very early after T cell activation and can act in an autocrine way, favoring Th1 versus Th17 differentiation and CCL19/CCL21 mediated migration. Recombinant inhibin A can restore the Th1/Th17 balance, highlighting the role of inhibins as key regulators of T cell ...
Sandra Ortega‐Francisco, Roxana Olguín‐Alor, Lizbeth Bolaños‐Castro, Alexandra Morales‐Cruz, Marisol De La Fuente‐Granada, Gloria Soldevila   +5 more
wiley   +1 more source

Airway responses and inflammation in subjects with asthma after four days of repeated high-single-dose allergen challenge [PDF]

, 2012
Background: Both standard and low-dose allergen provocations are an established tool in asthma research to improve our understanding of the pathophysiological mechanism of allergic asthma.
Rose, Markus A., Schubert, Ralf, Schulze, Johannes, Voss, Sandra, Zielen, Stefan, Zissler, Ulrich   +5 more
core   +2 more sources

Biomaterial Strategies for Targeted Intracellular Delivery to Phagocytes

Advanced Functional Materials, EarlyView.
Phagocytes are essential to a functional immune system, and their behavior defines disease outcomes. Engineered particles offer a strategic opportunity to target phagocytes, harnessing inflammatory modulation in disease. By tuning features like size, shape, and surface, these systems can modulate immune responses and improve targeted treatment for a ...
Kaitlyn E. Woodworth, Neal I. Callaghan, Locke Davenport Huyer   +2 more
wiley   +1 more source

Depleting T regulatory cells by targeting intracellular Foxp3 with a TCR mimic antibody

OncoImmunology, 2019
Depletion of T regulatory cells (Tregs) in the tumor microenvironment is a promising cancer immunotherapy strategy. Current approaches for depleting Tregs are limited by lack of specificity and concurrent depletion of anti-tumor effector T cells.
Tao Dao, Sung Soo Mun, Andrew C. Scott, Casey A. Jarvis, Tatyana Korontsvit, Zhiyuan Yang, Lianxing Liu, Martin G. Klatt, Manuel Guerreiro, Annamalai Selvakumar, Elliott J. Brea, Claire Oh, Cheng Liu, David A. Scheinberg   +13 more
doaj   +1 more source

Evaluation of FOXP3 and IL10 as immunosuppressant markers in pediatric acute lymphocytic leukemia patients in Iraq [PDF]

Romanian Journal of Pediatrics
Background. Increased FOXP3+ Treg levels in the TME were positively correlated with a worse prognosis in certain cancer patients. FOXP3 was significantly overexpressed in pediatric B-ALL patients, and this overexpression was associated with a worse ...
Zainab Jasim Mohammed, Maha Kalaf Zughair, Majid Noori Humoud, Sadeq K. Ali   +3 more
doaj   +1 more source

Self‐Immolative Activatable Nanoassembly toward Immuno‐Photodynamic Therapy in TME

Advanced Functional Materials, EarlyView.
A quinone methide‐gated, self‐immolative, H2O2‐responsive nano‐photosensitizer (Pyz/PS) is developed for targeted immuno‐photodynamic therapy. Pyz/PS selectively activates within tumor microenvironments, restores photosensitizer activity, generates ROS, and depletes intracellular GSH, enhancing oxidative stress.
Jing Li, E Pang, Snehasish Debnath, Jia Hong, Aojun Qiu, Dongeun Kim, Goeun Kim, Minhuan Lan, Min‐Goo Lee, Qian‐Yong Cao, Jong Seung Kim   +10 more
wiley   +1 more source

Multiomics Analyses Reveal an Essential Role of Tryptophan in Treatment of csDMARDs in Rheumatoid Arthritis

Advanced Science, EarlyView.
Rheumatoid arthritis is a disease characterized by joint inflammation. Approximately 50% of patients show insufficient response to traditional synthetic disease‐modifying antirheumatic drugs. This study aims to elucidate differential molecular profiles of the mechanisms underlying drug responses through multi‐omics strategy.
Congcong Jian, Jing Zhu, Jianhong Wu, Yan Zhang, Jianghua Chen, Huan Wang, Hengyan Liu, Ke Xu, Jiaxin Huang, Xiaoting Zhu, Yuanli Wei, Shilin Li, Tingting Wang, Xuan Huang, Qinghua Zou, Jie Zhang, Jiang Su, Xinming Du, Yaping Lu, Tianci Zhou, Yingtong Zhou, Minglong Tang, Bin Li, Xue Zhou, Qihao Wei, Qiulong Yan, Fanxin Zeng   +26 more
wiley   +1 more source

Association study of FOXP3 gene and the risk of 0020 pre-eclampsia

Clinical and Experimental Hypertension, 2018
Pre-eclampsia (PE) is a multifactorial pregnancy disorder, with serious consequences for both the mother and the fetus. Despite intense studies, the pathophysiology of PE remains enigmatic.
Milad Gholami, Reza Mirfakhraie, Reihaneh Pirjani, Robabeh Taheripanah, Sahar Bayat, Seyyedeh Anita Daryabari, Matina Noori, Sayyed Mohamad Hossein Ghaderian   +7 more
doaj   +1 more source

Association of FoxP3/Scurfin Germline Polymorphism (C-2383T/rs3761549) with Colorectal Cancer [PDF]

Iranian Journal of Colorectal Research, 2013
Background FoxP3 gene encodes a transcription factor with crucial roles in the development and function of regulatory T cells. Objectives The present study was conducted to investigate whether the C-2383T (rs3761549) polymorphism in the promoter ...
Zahra Mojtahedi, Nasrollah Erfani, Mohammad Reza Haghshenas, Seyed Vahid Hosseini, Abbas Ghaderi   +4 more
doaj   +1 more source