Lasso-grafted designer cytokines [PDF]
, 2023 Cytokine receptor agonists can be designed with longer half-lives in circulation and with enhanced penetration of the blood-brain barrier by genetically grafting macrocyclic peptides into the structural loops of fragment crystallizable ...
Bernhagen, Jurgen, Kapurniotu, Aphrodite
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Probing Hilbert space fragmentation and the block inverse participation ratio [PDF]
Phys. Rev. B 109, 064302 (2024), 2023 We consider a family of quantum many-body Hamiltonians that show exact Hilbert space fragmentation in certain limits. The question arises whether fragmentation has implications for Hamiltonians in the vicinity of the subset defined by these exactly fragmented models, in particular in the thermodynamic limit.
arxiv +1 more source
, 2010 Pur-α is a nucleic acid-binding protein involved in cell cycle control, transcription, and neuronal function. Initially no prediction of the three-dimensional structure of Pur-α was possible.
Graebsch, Almut +4 more
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Tumor necrosis factor inhibitors in psoriatic arthritis. [PDF]
, 2017 INTRODUCTION: Psoriatic arthritis (PsA) is a chronic inflammatory disease that can result in significant disability. With the emergence of tumor necrosis factor inhibitors (TNFi), therapeutic outcomes in PsA have improved substantially.
Kraft, Walter K. +2 more
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Monoclonal antibodies to treat multiple myeloma: A dream come true [PDF]
, 2020 Immunotherapy is increasingly used in the treatment of multiple myeloma (MM). Monoclonal antibodies (mAbs) are safe and effective ways to elicit immunotherapeutic responses.
Boccadoro, M. +3 more
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Molecular modeling of antibodies for the treatment of TNFα-related immunological diseases [PDF]
, 2016 Therapeutic monoclonal antibodies (mAbs) have high efficacy in treating TNF α-related immunological diseases. Other than neutralizing TNF α, these IgG1 antibodies exert Fc receptor-mediated effector functions such as the complement-dependent cytotoxicity
BOSSIS, FABRIZIO +6 more
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C3 Drives Inflammatory Skin Carcinogenesis Independently of C5 [PDF]
, 2021 Nonmelanoma skin cancer such as cutaneous squamous cell carcinoma (cSCC) is the most common form of cancer and can occur as a consequence of DNA damage to the epithelium by UVR or chemical carcinogens. There is growing evidence that the complement system
Belmonte, Beatrice +9 more
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Immunoglobulin G fragment crystallizable glycosylation after hematopoietic stem cell transplantation is dissimilar to donor profiles [PDF]
, 2018 Immunoglobulin G (IgG) fragment crystallizable (Fc) N-glycosylation has a large influence on the affinity of the antibody for binding to Fcγ-receptors (FcγRs) and C1q protein, thereby influencing immune effector functions.
de Haan, N. (Noortje) +4 more
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Of Bits and Bugs — On the Use of Bioinformatics and a Bacterial Crystal Structure to Solve a Eukaryotic Repeat-Protein Structure [PDF]
, 2010 Pur-α is a nucleic acid-binding protein involved in cell cycle control, transcription, and neuronal function. Initially no prediction of the three-dimensional structure of Pur-α was possible.
A Biegert +54 more
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Non-invasive thrombectomy: magnetized antibodies in reperfusion of thromboses [PDF]
, 2020 Background: Five multi-center randomized controlled trials have shown superior outcomes for mechanical thrombectomy to standard intravenous thrombolysis for acute anterior ischaemic stroke.
Alim-Marvasti, Ali
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