Results 1 to 10 of about 200,312 (175)

Certolizumab pegol in severe hidradenitis suppurativa in pregnancy: A case report. [PDF]

SAGE Open Med Case Rep
Hidradenitis suppurativa is a chronic inflammatory disease of the skin with a suppurative-cicatricial outcome affecting the infundibular component of the pilo-sebaceous unit.
Gisondi P, Montalto E, Curic T, Danese E, Bellinato F, Girolomoni G.   +5 more
europepmc   +2 more sources

Rapid In Vivo Screening of Monoclonal Antibody Cocktails Using Hydrodynamic Delivery of DNA-Encoded Modified Antibodies. [PDF]

Biomedicines
Background: Monoclonal antibodies (mAbs) are potent treatment options for infectious diseases. The rapid isolation and in vivo validation of therapeutic mAb candidates, including mAb cocktails, are essential to combat novel or rapidly mutating pathogens.
Fausther-Bovendo H, Babuadze GG, Ivanciuc T, Kalveram B, Qu Y, Choi J, McGeer A, Ostrowski M, Mubareka S, Patel A, Garofalo RP, Kozak R, Kobinger GP.   +12 more
europepmc   +2 more sources

MS-Based Allotype-Specific Analysis of Polyclonal IgG-Fc N-Glycosylation [PDF]

Frontiers in Immunology, 2020
Current approaches to study glycosylation of polyclonal human immunoglobulins G (IgG) usually imply protein digestion or glycan release. While these approaches allow in-depth characterization, they also result in a loss of valuable information regarding ...
Thomas Sénard, Andrea F. G. Gargano, Andrea F. G. Gargano, David Falck, Steven W. de Taeye, Steven W. de Taeye, Theo Rispens, Gestur Vidarsson, Manfred Wuhrer, Govert W. Somsen, Elena Domínguez-Vega   +10 more
doaj   +3 more sources

Pre-Clinical Studies of a Novel Bispecific Fusion Protein Targeting C3b and VEGF in Neovascular and Nonexudative AMD Models. [PDF]

Ophthalmol Ther
Introduction KNP-301 is a bi-specific fragment crystallizable region (Fc) fusion protein, which inhibits both C3b and vascular endothelial growth factor (VEGF) simultaneously for patients with late-stage age-related macular degeneration (AMD).
Lee Y, Kim D, Chung PED, Lee M, Kim N, Chang J, Lee BC.   +6 more
europepmc   +2 more sources

Designing receptor agonists with enhanced pharmacokinetics by grafting macrocyclic peptides into fragment crystallizable regions

Nature Biomedical Engineering, 2022
AbstractShort half-lives in circulation and poor transport across the blood–brain barrier limit the utility of cytokines and growth factors acting as receptor agonists. Here we show that surrogate receptor agonists with longer half-lives in circulation and enhanced transport rates across the blood–brain barrier can be generated by genetically inserting
Katsuya Sakai, Nozomi Sugano-Nakamura, Emiko Mihara, Nichole Marcela Rojas-Chaverra, Sayako Watanabe, Hiroki Sato, Ryu Imamura, Dominic Chih-Cheng Voon, Itsuki Sakai, Chihiro Yamasaki, Chise Tateno, Mikihiro Shibata, Hiroaki Suga, Junichi Takagi, Kunio Matsumoto   +14 more
openaire   +2 more sources

Enhancement of SARS-CoV-2 Infection via Crosslinking of Adjacent Spike Proteins by N-Terminal Domain-Targeting Antibodies

Viruses, 2023
The entry of SARS-CoV-2 into host cells is mediated by the interaction between the spike receptor-binding domain (RBD) and host angiotensin-converting enzyme 2 (ACE2).
Tina Lusiany, Tohru Terada, Jun-ichi Kishikawa, Mika Hirose, David Virya Chen, Fuminori Sugihara, Hendra Saputra Ismanto, Floris J. van Eerden, Songling Li, Takayuki Kato, Hisashi Arase, Matsuura Yoshiharu, Masato Okada, Daron M. Standley   +13 more
doaj   +1 more source

Lasso-grafted designer cytokines [PDF]

, 2023
Cytokine receptor agonists can be designed with longer half-lives in circulation and with enhanced penetration of the blood-brain barrier by genetically grafting macrocyclic peptides into the structural loops of fragment crystallizable ...
Bernhagen, Jurgen, Kapurniotu, Aphrodite
core   +1 more source

In vivo pharmacokinetic enhancement of monomeric Fc and monovalent bispecific designs through structural guidance

Communications Biology, 2021
Lu Shan et al. present a structure-guided approach to engineer a monovalent form of the fragment crystallizable (Fc) region of an IgG4 antibody to adapt multiple versions of half-life extension modifications and bispecific targeting.
Lu Shan, Nydia Van Dyk, Nantaporn Haskins, Kimberly M. Cook, Kim L. Rosenthal, Ronit Mazor, Sonia Dragulin-Otto, Yu Jiang, Herren Wu, William F. Dall’Acqua, Martin J. Borrok, Melissa M. Damschroder, Vaheh Oganesyan   +12 more
doaj   +1 more source

The therapeutic potential of sialylated Fc domains of human IgG

mAbs, 2021
Pathogens frequently use multivalent binding to sialic acid to infect cells or to modulate immunity through interactions with human sialic acid-binding immunoglobulin-type lectins (Siglecs).
Richard J. Pleass
doaj   +1 more source

Non-covalent Fc-Fab interactions significantly alter internal dynamics of an IgG1 antibody

Scientific Reports, 2022
The fragment-antigen-binding arms (Fab1 and Fab2) in a canonical immunoglobulin G (IgG) molecule have identical sequences and hence are always expected to exhibit symmetric conformations and dynamics.
Ramakrishnan Natesan, Neeraj J. Agrawal
doaj   +1 more source