Results 1 to 10 of about 8,153 (248)

Certolizumab pegol in severe hidradenitis suppurativa in pregnancy: A case report [PDF]

SAGE Open Medical Case Reports
Hidradenitis suppurativa is a chronic inflammatory disease of the skin with a suppurative-cicatricial outcome affecting the infundibular component of the pilo-sebaceous unit.
Paolo Gisondi, Elena Montalto, Tea Curic, Elisabetta Danese, Francesco Bellinato, Giampiero Girolomoni   +5 more
doaj   +2 more sources

Altered IgG N-Glycosylation at Onset of Type 1 Diabetes in Children Is Predominantly Driven by Changes in the Fab N-Glycans [PDF]

Biomedicines
Background: N-glycosylation is a post-translational modification involving the attachment of oligosaccharides to proteins and is known to influence immunoglobulin G (IgG) effector functions and even antigen binding.
Branimir Plavša, Najda Rudman, Flemming Pociot, Olga Gornik   +3 more
doaj   +2 more sources

The role of immunoglobulin E in non-atopic disorders [PDF]

Frontiers in Immunology
Immunoglobulin E (IgE) and its corresponding Fc epsilon receptors (FcϵRs) are essential components of the immune system. The constant, crystallizable fragment (Fc) region of IgE binds with high affinity to its specific receptor, FcϵRI, anchoring IgE ...
Kujtim Thaçi, Kujtim Thaçi, Aron Gyorgypal, Robert M. Anthony, Michelle E. Conroy   +4 more
doaj   +2 more sources

Identification of engineered IMGT Fc variants in IMGT/mAb-DB, a database of therapeutic antibodies and fusion proteins [PDF]

mAbs
Monoclonal antibodies (mAbs) and fusion proteins for immune applications (FPIA) play a crucial role in treating autoimmune diseases and cancers by targeting cell-surface proteins and triggering multiple immune mechanisms.
Taciana Manso, Gaoussou Sanou, Christos Nousias, Imene Maalem, François Boutin, Véronique Giudicelli, Patrice Duroux, Marie-Paule Lefranc, Sofia Kossida   +8 more
doaj   +2 more sources

Humanized VHH-hFc Fusion Proteins Targeting the L-HN Fragment of Tetanus Toxin Provided Protection In Vivo [PDF]

Antibodies
Background: Tetanus toxin, produced by Clostridium tetani, is the second deadliest known toxin. Antibodies capable of neutralizing tetanus toxin (TeNT) are vital for preventing and treating tetanus disease.
Yating Li, Kexuan Cheng, Jiazheng Guo, Yujia Jiang, Qinglin Kang, Rong Wang, Peng Du, Chen Gao, Yunzhou Yu, Zhixin Yang, Wei Wang, Jiansheng Lu   +11 more
doaj   +2 more sources

IGLV3-21^R110-directed bispecific antibodies activate T cells and promote killing in a high-risk subset of chronic lymphocytic leukemia

Haematologica
We previously used a disease-specific B cell receptor (BCR) point mutation (IGLV3-21R110) for selective targeting of a high-risk subset of chronic lymphocytic leukemia (CLL) with chimeric antigen receptor (CAR) T cells.
Claudia Fischer, Shih-Shih Chen, Johanna Nimmerfroh, Anne Eugster, Simon Stücheli, Christoph Schultheiß, Corinne Widmer, Dominik Heim, Benjamin Kasenda, Jakob Passweg, Sebastian Kobold, Lukas Egli, Nicolò Coianiz, Obinna Chijioke, Nicholas Chiorazzi, Marie Follo, Heinz Läubli, Matthias Peipp, Mascha Binder   +18 more
doaj   +2 more sources

Enhancement of SARS-CoV-2 Infection via Crosslinking of Adjacent Spike Proteins by N-Terminal Domain-Targeting Antibodies

Viruses, 2023
The entry of SARS-CoV-2 into host cells is mediated by the interaction between the spike receptor-binding domain (RBD) and host angiotensin-converting enzyme 2 (ACE2).
Tina Lusiany, Tohru Terada, Jun-ichi Kishikawa, Mika Hirose, David Virya Chen, Fuminori Sugihara, Hendra Saputra Ismanto, Floris J. van Eerden, Songling Li, Takayuki Kato, Hisashi Arase, Matsuura Yoshiharu, Masato Okada, Daron M. Standley   +13 more
doaj   +1 more source

In vivo pharmacokinetic enhancement of monomeric Fc and monovalent bispecific designs through structural guidance

Communications Biology, 2021
Lu Shan et al. present a structure-guided approach to engineer a monovalent form of the fragment crystallizable (Fc) region of an IgG4 antibody to adapt multiple versions of half-life extension modifications and bispecific targeting.
Lu Shan, Nydia Van Dyk, Nantaporn Haskins, Kimberly M. Cook, Kim L. Rosenthal, Ronit Mazor, Sonia Dragulin-Otto, Yu Jiang, Herren Wu, William F. Dall’Acqua, Martin J. Borrok, Melissa M. Damschroder, Vaheh Oganesyan   +12 more
doaj   +1 more source

The therapeutic potential of sialylated Fc domains of human IgG

mAbs, 2021
Pathogens frequently use multivalent binding to sialic acid to infect cells or to modulate immunity through interactions with human sialic acid-binding immunoglobulin-type lectins (Siglecs).
Richard J. Pleass
doaj   +1 more source

Non-covalent Fc-Fab interactions significantly alter internal dynamics of an IgG1 antibody

Scientific Reports, 2022
The fragment-antigen-binding arms (Fab1 and Fab2) in a canonical immunoglobulin G (IgG) molecule have identical sequences and hence are always expected to exhibit symmetric conformations and dynamics.
Ramakrishnan Natesan, Neeraj J. Agrawal
doaj   +1 more source