pyfraglib : An integrated cfDNA fragmentomics platform
Abstract Summary Cell-free DNA (cfDNA) fragmentomics is the analysis of a diverse set of cfDNA fragment features, e.g. fragment length profiles, windowed protection scores, and end motifs. As such it requires software tooling for fragment extraction, statistical feature modeling,
Daniel Schuette +5 more
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Background Gastrointestinal (GI) cancers are among the most prevalent and lethal malignancies worldwide. Early, non-invasive detection is essential for timely intervention and improved survival.
Ao Huang +28 more
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Multifeature sequencing-based liquid biopsy for cancer diagnosis and monitoring. [PDF]
Molina MA +4 more
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Correspondence to editorial on “Aberrant fragmentomic features of circulating cell-free mitochondrial DNA enable early detection and prognosis prediction of hepatocellular carcinoma” [PDF]
Yang Liu +3 more
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How advances in machine learning drive early detection and risk prediction of early-onset colorectal cancer. [PDF]
Murthy SS, Schuh A.
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Cell-Free DNA Fragmentation Patterns as Biomarkers for Human Papillomavirus-Related Cancers: A Systematic Review of Methodological Diversity and Diagnostic Performance. [PDF]
Santos F +7 more
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Author Correction: Quantitative fragmentomics allow affinity mapping of interactomes
Gergo Gogl +14 more
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fRagmentomics: an R package for integrating cell-free DNA fragment features with mutational status to support liquid biopsy interpretation. [PDF]
Maudet K +3 more
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Sinteza nove piridinijeve soli s triazolilidenskim fragmentom
This thesis describes the synthesis of a novel pyridinium salt bearing triazolylidene fragment bounded to pyridine nitrogen atom, which has not yet been described in the literature. The synthesized salt represents a potential bidentate dicarbene NHC ligand, useful for the formation of transition metal NHC complexes.
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