Results 61 to 70 of about 1,007 (120)

Comprehensive fragmentation of cell-free repetitive DNA for enhanced cancer detection in plasma

Frontiers in Cell and Developmental Biology
BackgroundRepetitive elements account for a large proportion of the human genome and undergo alterations during early tumorigenesis. However, the exclusive fragmentation pattern of DNA-derived cell-free repetitive elements (cfREs) remains unclear ...
Mingguang Zhang, Shuohui Dong, Wei Rao, Shiwen Mei, Gang Hu, Ling Liu, Zhen Wang, Jianqiang Tang   +7 more
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Abstracts

Molecular Oncology, Volume 20, Issue S1, Page 1-692, August 2026.
Abstracts submitted to the ‘EACR 2026 Congress: Innovative Cancer Science’, from 08–11 June 2026 and accepted by the Congress Organising Committee are published in this Supplement of Molecular Oncology, an affiliated journal of the European Association for Cancer Research (EACR).
wiley   +1 more source

Cell‐free epigenomes enhanced fragmentomics‐based model for early detection of lung cancer

Clinical and Translational Medicine
Background Lung cancer is a leading cause of cancer mortality, highlighting the need for innovative non‐invasive early detection methods. Although cell‐free DNA (cfDNA) analysis shows promise, its sensitivity in early‐stage lung cancer patients remains a
Yadong Wang, Qiang Guo, Zhicheng Huang, Liyang Song, Fei Zhao, Tiantian Gu, Zhe Feng, Haibo Wang, Bowen Li, Daoyun Wang, Bin Zhou, Chao Guo, Yuan Xu, Yang Song, Zhibo Zheng, Zhongxing Bing, Haochen Li, Xiaoqing Yu, Ka Luk Fung, Heqing Xu, Jianhong Shi, Meng Chen, Shuai Hong, Haoxuan Jin, Shiyuan Tong, Sibo Zhu, Chen Zhu, Jinlei Song, Jing Liu, Shanqing Li, Hefei Li, Xueguang Sun, Naixin Liang   +32 more
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Genome-wide cfDNA fragmentation patterns in cerebrospinal fluid reflect medulloblastoma groups

npj Precision Oncology
Identifying molecular groups in medulloblastoma currently requires invasive biopsies for accurate diagnosis. We analyzed cerebrospinal fluid cell-free DNA (cfDNA) fragmentation patterns in 122 samples as a minimally-invasive alternative.
Alexander L Markowitz, Chetan Munugula, Eirini Christodoulou, Jianling Ji, Liya Xu, Jennifer A Cotter, Venkata Yellapantula   +6 more
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Detection and characterization of pancreatic and biliary tract cancers using cell-free DNA fragmentomics

Journal of Experimental & Clinical Cancer Research
Background Plasma cell-free DNA (cfDNA) fragmentomics has demonstrated significant differentiation power between cancer patients and healthy individuals, but little is known in pancreatic and biliary tract cancers.
Xiaohan Shi, Shiwei Guo, Qiaonan Duan, Wei Zhang, Suizhi Gao, Wei Jing, Guojuan Jiang, Xiangyu Kong, Penghao Li, Yikai Li, Chuanqi Teng, Xiaoya Xu, Sheng Chen, Baoning Nian, Zhikuan Li, Chaoliang Zhong, Xiaolu Yang, Guangyu Zhu, Yiqi Du, Dadong Zhang, Gang Jin   +20 more
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Integrating multi‐omics features enables non‐invasive early diagnosis and treatment response prediction of diffuse large B‐cell lymphoma

Clinical and Translational Medicine
Background Multi‐omics features of cell‐free DNA (cfDNA) can effectively improve the performance of non‐invasive early diagnosis and prognosis of cancer. However, multimodal characterization of cfDNA remains technically challenging.
Weilong Zhang, Bangquan Ye, Yang Song, Ping Yang, Wenzhe Si, Hairong Jing, Fan Yang, Dan Yuan, Zhihong Wu, Jiahao Lyu, Kang Peng, Xu Zhang, Lingli Wang, Yan Li, Yan Liu, Chaoling Wu, Xiaoyu Hao, Yuqi Zhang, Wenxin Qi, Jing Wang, Fei Dong, Zijian Zhao, Hongmei Jing, Yanzhao Li   +23 more
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Poster Sessions

HemaSphere, Volume 10, Issue S1, June 2026.
wiley   +1 more source

A standardized framework for robust fragmentomic feature extraction from cell-free DNA sequencing data

Genome Biology
Fragmentomics features of cell-free DNA represent promising non-invasive biomarkers for cancer diagnosis. A lack of systematic evaluation of biases in feature quantification hinders the adoption of such applications.
Haichao Wang, Paulius D. Mennea, Yu Kiu Elkie Chan, Zhao Cheng, Maria C. Neofytou, Arif Anwer Surani, Aadhitthya Vijayaraghavan, Emma-Jane Ditter, Richard Bowers, Matthew D. Eldridge, Dmitry S. Shcherbo, Christopher G. Smith, Florian Markowetz, Wendy N. Cooper, Tommy Kaplan, Nitzan Rosenfeld, Hui Zhao   +16 more
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GUIDE: a prospective cohort study for blood-based early detection of gastrointestinal cancers using targeted DNA methylation and fragmentomics sequencing

Molecular Cancer
Background Gastrointestinal (GI) cancers are among the most prevalent and lethal malignancies worldwide. Early, non-invasive detection is essential for timely intervention and improved survival.
Ao Huang, De-Zhen Guo, Zhi-Xi Su, Yun-Shi Zhong, Liang Liu, Zhi-Guo Xiong, Dong-Li He, Bin Yan, Quan-Lin Li, Zhen Feng, Wen-Quan Wang, Pin-Xiang Lu, Meng-Jiang He, Zhi-Peng Qi, Qi Guo, Jian-Wen Cheng, Shi-Yu Zhang, Wei Guo, Qing Li, Guo-Yong Lin, Hui-Chuan Sun, Shuang-Jian Qiu, Qi-Ye He, Jia Fan, Ajay Goel, Rui Liu, Gang Jin, Xin-Rong Yang, Jian Zhou   +28 more
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Multifeature sequencing-based liquid biopsy for cancer diagnosis and monitoring. [PDF]

Genome Med
Molina MA, De Simoni M, Moldovan N, Mouliere F, Hagey DW.   +4 more
europepmc   +1 more source