Results 111 to 120 of about 1,183 (178)

DeepFRAG: a method for cancer detection based on DNA fragmentomics and deep learning

Bioinformatics Advances
Abstract Motivation Cancer screening using liquid biopsy technology has become standard in modern clinical and preventive oncology. This method analyzes cell-free DNA (cfDNA) circulating in a patient’s bloodstream.
Andrey Koch, Eldar Giladi
openaire   +3 more sources

Integrating multi‐omics features enables non‐invasive early diagnosis and treatment response prediction of diffuse large B‐cell lymphoma

Clinical and Translational Medicine
Background Multi‐omics features of cell‐free DNA (cfDNA) can effectively improve the performance of non‐invasive early diagnosis and prognosis of cancer. However, multimodal characterization of cfDNA remains technically challenging.
Weilong Zhang, Bangquan Ye, Yang Song, Ping Yang, Wenzhe Si, Hairong Jing, Fan Yang, Dan Yuan, Zhihong Wu, Jiahao Lyu, Kang Peng, Xu Zhang, Lingli Wang, Yan Li, Yan Liu, Chaoling Wu, Xiaoyu Hao, Yuqi Zhang, Wenxin Qi, Jing Wang, Fei Dong, Zijian Zhao, Hongmei Jing, Yanzhao Li   +23 more
doaj   +1 more source

Cancer‐Like Fragmentomic Characteristics of Somatic Variants in Cell‐Free DNA

Advanced Science
ABSTRACT Cell‐free DNA (cfDNA) in plasma consists of short DNA fragments resulting from a non‐random fragmentation process, with distinct fragmentomic characteristics that are related with their cellular origins. Here, we report that somatic variant signatures in cfDNA markedly differ between non‐cancerous controls and cancer patients,
Zhenyu Zhang, Yunyun An, Mengqi Yang, Yuqi Pan, Xiaoyi Liu, Fanglei Gong, Huizhen Lin, Bianbian Tang, Yunxia Bai, Xin Zhao, Yu Zhao, Changzheng Du, Kun Sun   +12 more
openaire   +2 more sources

Fragmentation signatures in cancer patients resemble those of patients with vascular or autoimmune diseases

Multiple case-controlled studies have shown that analyzing fragmentation patterns in plasma cell-free DNA (cfDNA) can distinguish individuals with cancer from healthy controls.
Kinzler, KW, Liu, T, O’Reilly, E, Mulder, F, Li, A, Vogelstein, B, Dobbyn, L, Ho-Pham, LT, Bettegowda, C, Popoli, M, Mecoli, CA, Panda, S, Xu, H, Bai, Y, Konig, MF, Papadopoulos, N, Wang, Y, Ptak, J, Douville, C, Silliman, N, van Es, N, Tie, J, Curtis, SD, Shah, AA, Thoburn, C, Tran, TS, Tran, BNH, Nguyen, TV, Gibbs, P, Rosen, A, Vogelstein, JT, Petri, M   +31 more
core   +1 more source

Chasing the code : Advancing Precision Diagnostics through Next Generation Sequencing

Next generation sequencing (NGS) has revolutionized precision diagnostics by enabling high-throughput analysis of nucleic acids. This thesis combines technical validations with innovative applications of NGS across five studies.
Adolfsson, Emma
core   +2 more sources

Integration of Cell-Free DNA End Motifs and Fragment Lengths Can Identify Active Genes in Liquid Biopsies

Multiple studies have shown that cell-free DNA (cfDNA) from cancer patients differ in both fragment length and fragment end motif (FEM) from healthy individuals, yet there is a lack of understanding of how the two factors combined are associated with ...
Anders Lade Nielsen, Christoffer Trier Maansson, Peter Meldgaard, Louise Skov Thomsen, Boe Sandahl Sorensen   +4 more
core   +1 more source

Correspondence to editorial on “Aberrant fragmentomic features of circulating cell-free mitochondrial DNA enable early detection and prognosis prediction of hepatocellular carcinoma” [PDF]

Clinical and Molecular Hepatology
Yang Liu, Fan Peng, Siyuan Wang, Jinliang Xing   +3 more
doaj   +1 more source

Author Correction: Quantitative fragmentomics allow affinity mapping of interactomes

Nature Communications, 2022
Gergo Gogl, Boglarka Zambo, Camille Kostmann, Alexandra Cousido-Siah, Bastien Morlet, Fabien Durbesson, Luc Negroni, Pascal Eberling, Pau Jané, Yves Nominé, Andras Zeke, Søren Østergaard, Élodie Monsellier, Renaud Vincentelli, Gilles Travé   +14 more
doaj   +1 more source

Multifeature sequencing-based liquid biopsy for cancer diagnosis and monitoring. [PDF]

Genome Med
Molina MA, De Simoni M, Moldovan N, Mouliere F, Hagey DW.   +4 more
europepmc   +1 more source

Cell-free DNA fragmentome analysis informs pregnancy outcome in patients with immune-mediated disease

Pregnancy complications contribute substantially to maternal and fetal morbidity and mortality. If complications are suspected early in pregnancy, individuals could be triaged to escalate care and ideally reduce adverse outcomes.
Bernard Thienpont, Ilse Parijs, Kate E. Stanley, Kris Van Den Bogaert, Wilfried Gyselaers, Lore Lannoo, Tatjana Jatsenko, Erika Souche, Koenraad Devriendt, Joris R. Vermeesch, Leen Vancoillie, Ivo Salden, Kristel Van Calsteren   +12 more
core   +1 more source