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Cell-Free DNA Fragmentomics: The Novel Promising Biomarker
International Journal of Molecular Sciences, 2023 Cell-free DNA molecules are released into the plasma via apoptotic or necrotic events and active release mechanisms, which carry the genetic and epigenetic information of its origin tissues. However, cfDNA is the mixture of various cell fragments, and the efficient enrichment of cfDNA fragments with diagnostic value remains a great challenge for ...
Qinyu Ge, Min Pan, Yunfei Bai
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Emerging frontiers of cell-free DNA fragmentomics
Extracellular Vesicles and Circulating Nucleic Acids, 2022 Analysis of cell-free DNA (cfDNA) in the blood has shown promise for monitoring a variety of biological processes. Plasma cfDNA is a mixture comprising DNA molecules released from various bodily tissues, mediated by characteristic DNA fragmentations occurring during cell death.
Peiyong Jiang
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Cell-free DNA fragmentomics in cancer
Cancer CellThe analysis of cell-free DNA (cfDNA) fragmentation patterns, known as "fragmentomics," has opened new opportunities in noninvasive cancer diagnostics. Due to its close relationships with genomic organization and cell death, cfDNA fragmentomics lies at the intersection of many aspects of cancer biology, including epigenetic dysregulation ...
Peiyong Jiang, Y M Dennis Lo
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Fragmenting the future with FLARE: a comprehensive fragmentomics pipeline based on long-read nanopore sequencing [PDF]
Frontiers in GeneticsPurposeCell-free DNA (cfDNA) fragmentation patterns carry biological information beyond fragment length, revealing nuclease activity, chromatin organization, and tissue of origin.
Marica Ficorilli +14 more
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DECIPHER-PRAD: an advanced fragmentomics-based cell-free DNA assay for prostate cancer early detection [PDF]
Cell Communication and SignalingEarly detection of prostate cancer is limited by the poor specificity of prostate-specific antigen (PSA)-based screening. Cell-free DNA (cfDNA) fragmentomics offers a promising non-invasive approach to improve screening accuracy and risk stratification ...
Shun Zhang +13 more
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Liquid Biopsy in Early Screening of Cancers: Emerging Technologies and New Prospects [PDF]
BiomedicinesLiquid biopsy is moving beyond mutation-centric assays to multimodal frameworks that integrate cell-free DNA (cfDNA) signals with additional analytes such as circulating tumor cells (CTCs) and extracellular vesicles (EVs).
Hanyu Zhu +10 more
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Cell-free nucleic acid fragmentomics: A non-invasive window into cellular epigenomes
Translational OncologyClinical genomic profiling of cell-free nucleic acids (e.g. cell-free DNA or cfDNA) from blood and other body fluids has ushered in a new era in non-invasive diagnostics and treatment monitoring strategies for health conditions and diseases such as ...
Subhajyoti De
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Fragmentomics features of ovarian cancer
International Journal of CancerAbstractOvarian cancer (OC) is a major cause of cancer mortality in women worldwide. Due to the occult onset of OC, its nonspecific clinical symptoms in the early phase, and a lack of effective early diagnostic tools, most OC patients are diagnosed at an advanced stage.
Lei Li, Jing Wang, Huanwen Wu
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Clinical and Translational MedicineEarly detection of gastrointestinal (GI) cancers remains a critical unmet clinical need, as most patients are diagnosed at advanced stages when prognosis is poor.
Muhammad Anees +11 more
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Circulating Cell-free DNA Fragmentomics Detection and Beyond
aging and diseaseCirculating cell-free DNA (cfDNA) comprises DNA fragments released into bodily fluids via apoptosis, necrosis, or phagocytosis. cfDNA encapsulates both fragmentomics (structural) and non-fragmentomics (sequence/epigenetic) information from source cells, thereby representing a promising biomarker.
Tianliang, Liu +3 more
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