Results 31 to 40 of about 878 (143)

Multidimensional cell-free DNA fragmentomics enables early detection of breast cancer [PDF]

Breast Cancer Research
Background Cell-free DNA (cfDNA) fragmentomics represents a transformative approach for early breast cancer detection, offering significant potential to improve patient survival through timely intervention.
Lixian Yang, Mengyang An, Heng song, Xuan Zhang, Meiqi Wang, Liu Yang, Xinle Wang, Hua Yang, Xinyue Hong, Zhenchuan Song   +9 more
doaj   +2 more sources

Multidimensional roles of cfDNA fragmentomics in preeclampsia: from placental hypoxia and TLR9 inflammation to clinical risk stratification [PDF]

Frontiers in Medicine
Cell-free DNA (cfDNA) has emerged as a pivotal biomarker for predicting preeclampsia (PE), a multisystem syndrome characterized by placental hypoperfusion and systemic inflammation.
Ziyi Guo, Bin Zhang, Di Yang, Li Wang
doaj   +2 more sources

Cell-free DNA fragmentomics: a universal framework for early cancer detection and monitoring. [PDF]

Am J Clin Exp Immunol
Cell-free DNA (cfDNA) fragmentomics has emerged as a powerful and noninvasive approach for cancer detection, characterization, and monitoring. By analyzing genome-wide fragmentation patterns - including fragment length distributions, end motifs, nucleosome footprints, and copy number variations - cfDNA fragmentomics provides high-resolution insights ...
Dong W, Hu W, Lu Y, Zheng Q.
europepmc   +3 more sources

Fragmentomics of urinary cell-free DNA in nuclease knockout mouse models.

PLoS Genetics, 2022
Urinary cell-free DNA (ucfDNA) is a potential biomarker for bladder cancer detection. However, the biological characteristics of ucfDNA are not well understood.
Meihui Chen, Rebecca W Y Chan, Peter P H Cheung, Meng Ni, Danny K L Wong, Ze Zhou, Mary-Jane L Ma, Liangbo Huang, Xinzhou Xu, Wing-Shan Lee, Guangya Wang, Kathy O Lui, W K Jacky Lam, Jeremy Y C Teoh, Chi-Fai Ng, Peiyong Jiang, K C Allen Chan, Rossa W K Chiu, Y M Dennis Lo   +18 more
doaj   +3 more sources

Cell-free DNA fragmentomics for preeclampsia risk assessment

Nature Communications
Preeclampsia (PE) is a pregnancy-specific hypertensive disorder that could lead to serious maternal and fetal complications, yet early identification of women at risk remains challenging because reliable biomarkers are limited.
Wenqiu Xu, Songchang Chen, Jia Li, Si Zhou, Yanning Yin, Zhixu Qiu, Jianguo Zhang, Cong Liu, Qiang Zhao, Gefei Xiao, Yan Zhou, Zhiguang Zhao, Xiao Zhang, Wenzhi Yang, Yunfang Wang, Huiqin Li, Zhen Yang, Suihua Feng, Qun Zhang, Weiping Chen, Huahua Li, Xiaohong Ruan, Hua Li, Sufen Zhang, Liqing Hu, Jie Qin, Wuyan Huang, Zhongzhe Li, Xianling Cao, Xuanyou Zhou, Naixin Xu, Dongxia Hou, Hong Dong, Jie Wang, Yaxian Liu, Quanfu Zhang, Xiaohua Wang, Lijian Zhao, Hefeng Huang, Chenming Xu   +39 more
doaj   +2 more sources

Comprehensive fragmentation of cell-free repetitive DNA for enhanced cancer detection in plasma [PDF]

Frontiers in Cell and Developmental Biology
BackgroundRepetitive elements account for a large proportion of the human genome and undergo alterations during early tumorigenesis. However, the exclusive fragmentation pattern of DNA-derived cell-free repetitive elements (cfREs) remains unclear ...
Mingguang Zhang, Shuohui Dong, Wei Rao, Shiwen Mei, Gang Hu, Ling Liu, Zhen Wang, Jianqiang Tang   +7 more
doaj   +2 more sources

Fragmentomic liquid biopsy enables early breast cancer detection, molecular subtyping and lymph node assessment [PDF]

Nature Communications
Breast cancer remains a leading global health concern in women, while screening is still limited by imaging accessibility and reduced sensitivity in dense breasts.
Yuxuan Zhu, Siwei Zheng, Yinkuan Shao, Jun Zhou, Xidong Gu, Lesang Shen, Xue Li, Wenjia Liu, Wei Xue, Haiqi Lu, Jun Zhou, Jinghua Ding, Haiming Deng, Jiayin Chen, Zhuohang Yu, Yao Yao, Wenjie Xia, Wuzhen Chen, Shanshan Sun, Zheng Wang, Tianyi Qian, Xiuyan Yu, Jian Liu, Yiding Chen, Ziao Lin, Jian Huang, Chao Ni   +26 more
doaj   +2 more sources

GUIDE: a prospective cohort study for blood-based early detection of gastrointestinal cancers using targeted DNA methylation and fragmentomics sequencing [PDF]

Molecular Cancer
Background Gastrointestinal (GI) cancers are among the most prevalent and lethal malignancies worldwide. Early, non-invasive detection is essential for timely intervention and improved survival.
Ao Huang, De-Zhen Guo, Zhi-Xi Su, Yun-Shi Zhong, Liang Liu, Zhi-Guo Xiong, Dong-Li He, Bin Yan, Quan-Lin Li, Zhen Feng, Wen-Quan Wang, Pin-Xiang Lu, Meng-Jiang He, Zhi-Peng Qi, Qi Guo, Jian-Wen Cheng, Shi-Yu Zhang, Wei Guo, Qing Li, Guo-Yong Lin, Hui-Chuan Sun, Shuang-Jian Qiu, Qi-Ye He, Jia Fan, Ajay Goel, Rui Liu, Gang Jin, Xin-Rong Yang, Jian Zhou   +28 more
doaj   +2 more sources

Fragmentomics features of cell free DNA in eating disorders

Translational Psychiatry
Eating disorders are lacking reliable biomarkers despite their severe psychiatric and medical burden. In this study, we examined plasma cell-free DNA (cfDNA) from patients with the restrictive (ANR), or binge–purge (ANBP) subtypes of anorexia nervosa, as
Alisa Burova, Camille Verebi, Nicolas Lebrun, Juliette Nectoux, Audrey Boutonnet, Philibert Duriez, Philip Gorwood, Nicolas Ramoz, Thierry Bienvenu   +8 more
doaj   +2 more sources

Early detection of urological tumors based on genomic characteristics of cell-free DNA fragments: a multi-center study [PDF]

npj Precision Oncology
Cell-free DNA (cfDNA) has shown potential in distinguishing cancer patients from healthy individuals. This study investigates cfDNA fragmentomics—fragmentation patterns, end motifs (EDMs), and breakpoint motifs (BPMs)—to develop an early detection method
Huiyong Zhang, Caihong Huang, Chunmeng Wei, Rongbin Zhou, Chengbang Wang, Wenhao Lu, Zuheng Wang, Xiao Li, Shaohua Chen, Dianyu Wang, Jin Ji, Yuexiang Li, Rirong Yang, Junyi Chen, Yanling Hu, Fubo Wang   +15 more
doaj   +2 more sources