Results 71 to 80 of about 886 (145)

Genome-wide cfDNA fragmentation patterns in cerebrospinal fluid reflect medulloblastoma groups

npj Precision Oncology
Identifying molecular groups in medulloblastoma currently requires invasive biopsies for accurate diagnosis. We analyzed cerebrospinal fluid cell-free DNA (cfDNA) fragmentation patterns in 122 samples as a minimally-invasive alternative.
Alexander L Markowitz, Chetan Munugula, Eirini Christodoulou, Jianling Ji, Liya Xu, Jennifer A Cotter, Venkata Yellapantula   +6 more
doaj   +1 more source

Genomic and fragmentomic landscapes of cell-free DNA for early cancer detection

Nature Reviews Cancer
Genomic analyses of cell-free DNA (cfDNA) in plasma are enabling noninvasive blood-based biomarker approaches to cancer detection and disease monitoring. Current approaches for identification of circulating tumour DNA typically use targeted tumour-specific mutations or methylation analyses.
Daniel C. Bruhm, Nicholas A. Vulpescu, Zachariah H. Foda, Jillian Phallen, Robert B. Scharpf, Victor E. Velculescu   +5 more
openaire   +3 more sources

A method of comprehensive sequencing analysis of the small RNA fragmentome (RiboMarker)

RNA
Circulating cell-free nucleic acids (cfDNA and cfRNA) found in blood and other biofluids are promising biomarkers for cancer. However, current methods exploiting tumor-derived cfDNA (ctDNA) are not sensitive enough in detecting minimal residual disease and early stages of cancer when it is more treatable.
Rachel C. Clark, Aidan C. Manning, Jonathan M. Howard, Sergio Barberán-Soler, Sergei A. Kazakov   +4 more
openaire   +2 more sources

Protein-oligopeptide fragmentomics

, 2008
8
openaire   +2 more sources

Detection and characterization of pancreatic and biliary tract cancers using cell-free DNA fragmentomics

Journal of Experimental & Clinical Cancer Research
Background Plasma cell-free DNA (cfDNA) fragmentomics has demonstrated significant differentiation power between cancer patients and healthy individuals, but little is known in pancreatic and biliary tract cancers.
Xiaohan Shi, Shiwei Guo, Qiaonan Duan, Wei Zhang, Suizhi Gao, Wei Jing, Guojuan Jiang, Xiangyu Kong, Penghao Li, Yikai Li, Chuanqi Teng, Xiaoya Xu, Sheng Chen, Baoning Nian, Zhikuan Li, Chaoliang Zhong, Xiaolu Yang, Guangyu Zhu, Yiqi Du, Dadong Zhang, Gang Jin   +20 more
doaj   +1 more source

Poster Sessions

HemaSphere, Volume 10, Issue S1, June 2026.
wiley   +1 more source

A standardized framework for robust fragmentomic feature extraction from cell-free DNA sequencing data

Genome Biology
Fragmentomics features of cell-free DNA represent promising non-invasive biomarkers for cancer diagnosis. A lack of systematic evaluation of biases in feature quantification hinders the adoption of such applications.
Haichao Wang, Paulius D. Mennea, Yu Kiu Elkie Chan, Zhao Cheng, Maria C. Neofytou, Arif Anwer Surani, Aadhitthya Vijayaraghavan, Emma-Jane Ditter, Richard Bowers, Matthew D. Eldridge, Dmitry S. Shcherbo, Christopher G. Smith, Florian Markowetz, Wendy N. Cooper, Tommy Kaplan, Nitzan Rosenfeld, Hui Zhao   +16 more
doaj   +1 more source

Exploring global cfDNA fragmentomics as a biomarker in real-world patients with melanoma

Journal of Investigative Dermatology
Circulating cell-free DNA fragmentomics-the analysis of cell-free DNA fragment-length profiles-has been explored as a biomarker across cancers, but evidence in melanoma is limited. We conducted a longitudinal prospective study of 235 patients with American Joint Committee on Cancer stages II-IV melanoma (549 plasma samples) and 11 phenotypic high-risk ...
Daniel Rizo-Potau, Anton Forniés-Mariné, José Luis Villanueva-Cañas, Michelle Aguilar, Cristina Sánchez-Cárdenas, Teresa Torres, Sebastian Podlipnik, Cristina Carrera, Susana Puig, Josep Malvehy, Joan Anton Puig-Butillé   +10 more
openaire   +2 more sources

Integrating multi‐omics features enables non‐invasive early diagnosis and treatment response prediction of diffuse large B‐cell lymphoma

Clinical and Translational Medicine
Background Multi‐omics features of cell‐free DNA (cfDNA) can effectively improve the performance of non‐invasive early diagnosis and prognosis of cancer. However, multimodal characterization of cfDNA remains technically challenging.
Weilong Zhang, Bangquan Ye, Yang Song, Ping Yang, Wenzhe Si, Hairong Jing, Fan Yang, Dan Yuan, Zhihong Wu, Jiahao Lyu, Kang Peng, Xu Zhang, Lingli Wang, Yan Li, Yan Liu, Chaoling Wu, Xiaoyu Hao, Yuqi Zhang, Wenxin Qi, Jing Wang, Fei Dong, Zijian Zhao, Hongmei Jing, Yanzhao Li   +23 more
doaj   +1 more source

Epigenetic modifications of cfDNA in liquid biopsy for the cancer care continuum

Biomedical Journal
This review provides a comprehensive overview of the latest advancements in the clinical utility of liquid biopsy, with a particular focus on epigenetic approaches aimed at overcoming challenges in cancer diagnosis and treatment. It begins by elucidating
Jodie Wong, Rohit Muralidhar, Liang Wang, Chiang-Ching Huang   +3 more
doaj   +1 more source