Results 51 to 60 of about 960 (168)

Multi-signal cell-free DNA analysis for cancer detection [PDF]

, 2023
In this thesis, we explored the potential of circulating cell-free DNA (cfDNA) metrics for non-invasive cancer detection and therapy response prediction, leveraging whole genome sequencing (WGS) data. Our research was divided into two parts.
van der Pol, Ymke
core   +1 more source

Characterization of fragment sizes, copy number aberrations and 4‐mer end motifs in cell‐free DNA of hepatocellular carcinoma for enhanced liquid biopsy‐based cancer detection

Molecular Oncology, 2021
Circulating cell‐free DNA (cfDNA) fragmentomics, which encompasses the measurement of cfDNA length and short nucleotide motifs at the ends of cfDNA molecules, is an emerging field for cancer diagnosis.
Chao Jin, Xiaonan Liu, Wenyuan Zheng, Liping Su, Yang Liu, Xu Guo, Xiaoming Gu, Hongping Li, Bo Xu, Gang Wang, Jiyan Yu, Qiong Zhang, Dengke Bao, Shaogui Wan, Fei Xu, Xiaohuan Lai, Jiayun Liu, Jinliang Xing   +17 more
doaj   +1 more source

Aberrant fragmentomic features of circulating cell-free mitochondrial DNA enable early detection and prognosis prediction of hepatocellular carcinoma [PDF]

Clinical and Molecular Hepatology
Background/Aims Early detection and effective prognosis prediction in patients with hepatocellular carcinoma (HCC) provide an avenue for survival improvement, yet more effective approaches are greatly needed.
Yang Liu, Fan Peng, Siyuan Wang, Huanmin Jiao, Kaixiang Zhou, Wenjie Guo, Shanshan Guo, Miao Dang, Huanqin Zhang, Weizheng Zhou, Xu Guo, Jinliang Xing   +11 more
doaj   +1 more source

Multimodal analysis of methylomics and fragmentomics in plasma cell-free DNA for multi-cancer early detection and localization

, 2023
Despite their promise, circulating tumor DNA (ctDNA)-based assays for multi-cancer early detection face challenges in test performance, due mostly to the limited abundance of ctDNA and its inherent variability.
Boi Hoan Huu Phan, Thi Thanh Do, Le Son Tran, Hung Sang Tang, Giang Thi Huong Nguyen, Ngan Chau Tran, Thanh Xuan Jasmine, Minh Nguyen Nguyen, Minh Long Duong, Duc Huy Tran, Hoai-Nghia Nguyen, Thi Hue Hanh Nguyen, Trung Kien Le, Minh-Duy Phan, Thanh Dang Nguyen, Minh Triet Le, Van Thinh Cao, Vu Tuan Anh Nguyen, Thuy Thi Thu Tran, Le Minh Quoc Ho, Thi Minh Thu Tran, Minh Phong Le, Anh Nhu Nguyen, Thanh Hai Phan, Van Chu Nguyen, Thuy Nguyen Doan, Quang Dat Tran, Thanh-Thuy Thi Do, Thanh Dat Nguyen, Thi Thu Thuy Pham, Hoa Giang, Trung Hieu Tran, Van Vu Kim, Tan Dat Ho, Huu Thinh Nguyen, The Anh Pham, Trong Hieu Nguyen, Thanh Nhan Vo Nguyen, Truong Vinh Ngoc Pham, Nhu Nhat Tan Doan, Thi Mong Quynh Pham, Trieu Vu Nguyen, Trinh Ngoc An Le, Thi Tuong Vi Van, Quang Thong Dang, Viet Hai Nguyen, Thuy Trang Tran, Vu Uyen Tran, Anh Minh Tran, Thanh Huong Thi Tran, Dung Thai Bieu Phu, Thi Trang Tran, Duy Long Vo, Thi Huong Thoang Nai, Duy Sinh Nguyen, Van Thien Chi Nguyen, Thi Van Phan, Hoai Phuong Thi Bach, Dac Ho Vo, My Hoang Truong, Hong-Dang Luu Nguyen, Thi Loan Vo, Bao Toan Nguyen, Le Anh Khoa Huynh, Dinh Kiet Truong   +64 more
core   +1 more source

Fragmentomics of natural peptide structures

Biochemistry (Moscow), 2009
Natural fragmentation of peptide and other chemical structures is well known. They are a significant object of biochemical investigations. In this connection, the bases and determination are given for the notion of the "fragmentome" as a set of all fragments of a single substance, as well as for global fragmentome of all chemical components of living ...
openaire   +4 more sources

Exploration of cfDNA landscape in NIPT and clinical utilities of cfDNA based gene expression inference in prenatal diagnostics

Frontiers in Genetics
Cell-free DNA (cfDNA) is a dynamic biomarker reflecting the physiological state of the body. Its unique physical and biochemical properties, inherited from the tissue of origin, enable a wide range of clinical applications.
Ruo Jia, Jianjiang Zhu, Feng Zhang, Yangbo Sun, Bin Zhang, Yang Du, Hong Qi   +6 more
doaj   +1 more source

Pancreatic Cancer Early Detection Biomarkers for High‐Risk Individuals: Insights From the PRECEDE Consortium

International Journal of Cancer, EarlyView.
ABSTRACT Pancreatic ductal adenocarcinoma (PDAC) remains one of the deadliest cancers due to its asymptomatic progression, late‐stage diagnosis, and treatment resistance. Efforts in early detection have centered on identifying imaging features and liquid biopsy biomarkers capable of detecting PDAC and its high‐grade precursors before clinical symptoms ...
Christine Worthington, Maria Raitses‐Gurevich, Giulio Innamorati, Phil A. Hart, Thomas M. Wilkie, Noam Tau, Dana Brin, Doron Yablecovitch, Ido Laish, Dove Keith, Kurt Giles, Jennifer B. Permuth, Diane M. Simeone, George Zogopoulos, Randall E. Brand, John J. Graff, Julie Earl, On behalf of the PRECEDE Consortium, Nikhil Agarwal, Laufey Amundadottir, Michelle Anderson, Ajay Bansal, Todd Bauer, Georg Beyer, Yan Bi, Erkut Borazanci, Randy Brand, Teri Brentnall, Carol Burke, Darren Carpizo, Saurabh Chawla, Daniel Chung, Sourat Darabi, Michael Demeure, Timothy Donahue, Julie Earl, Whitney Espinel, James Farrell, Vigdís Fjóla Stefánsdóttir, Jared Forrester, Eitan Friedman, Paul Franklin, Srinivas Gaddam, Ana García García de Paredes, Steven Gallinger, Talia Golan, Ora Gordon, Robert Grant, William Greenhalf, Eli Marie Grindedal, Aaron Grossberg, Brenda Hafers, Heather Hannon, Sigurdís Haraldsdóttir, Stefán Haraldsson, Peter Hegyi, Melissa Hogg, Amy de Haar‐Holleman, Susan Hong, Greg Idos, Edward Kim, Fay Kastrinos, Bryson Katona, Vivek Kaul, Derk Klatte, Kelsey Klute, Kimberly Ku, Sonia Kupfer, Rich Kwon, Rosario Ligresti, James James Lin, Wei‐Chih (David) Liao, Aimee Lucas, Nipun Merchant, Andrew Metz, Whitney Maxwell, James McLoughlin, Sodech Miclette, Xavier Molero, Leticia Moreira, Takuji Okusaka Chigusa Morizane, Joanne Ngeow, Salvatore Paiella, Jennifer Permuth, Maricel Purcell, Joshua Raff, Vineet Rolston, Intan Schrader, Rosie Sears, Yan‐Shen Shan, Diane Simeone, Jens Siveke, Brett Sheppard, Tyler Stevens, Elena Stoffel, Dan Sussman, Margaret Tempero, Jose Trevino, Jennifer Valerin, Eva Vaquero, Ray Wadlow, Garrett Ward, David Weinberg, Ronald Wolf, Dana Zakalik, George Zogopoulos   +105 more
wiley   +1 more source

Liquid biopsy in genitourinary oncology: Current clinical applications and future prospects across prostate, bladder, and renal cancers

UroPrecision, EarlyView.
Abstract Liquid biopsy has emerged as a transformative approach in oncology, providing minimally invasive access to tumor‐derived biomarkers with applications across diagnosis, prognosis, therapeutic guidance, and disease monitoring. This literature review synthesizes evidence from 125 studies evaluating circulating tumor DNA, circulating tumor cells ...
Kirolos Eskandar
wiley   +1 more source

The circulating cell-free DNA landscape in sepsis is dominated by impaired liver clearance

Cell Genomics
Summary: Circulating cell-free DNA (cfDNA) is a promising molecular biomarker, but its role in severe infection is unclear. Here, we profile cfDNA from sepsis patients and controls, demonstrating a 41-fold increase during disease.
Kiki Cano-Gamez, Patrick Maclean, Masato Inoue, Sakineh Hussainy, Elisabeth Foss, Chloe Wainwright, Hanyu Qin, Stuart McKechnie, Chun-Xiao Song, Julian C. Knight   +9 more
doaj   +1 more source

The emerging clinical relevance of cell-free DNA in lupus: from mechanistic insights to therapeutic opportunities

Frontiers in Immunology
Systemic lupus erythematosus (SLE) is a complex autoimmune disease often characterised by dysregulated immune responses to self-DNA. Emerging evidence highlights the role of cell-free DNA (cfDNA) in promoting immune activation in SLE.
Emily Jones, Kiki Cano-Gamez
doaj   +1 more source