Results 11 to 20 of about 838 (99)

Comprehensive fragmentation of cell-free repetitive DNA for enhanced cancer detection in plasma. [PDF]

Front Cell Dev Biol
BackgroundRepetitive elements account for a large proportion of the human genome and undergo alterations during early tumorigenesis. However, the exclusive fragmentation pattern of DNA-derived cell-free repetitive elements (cfREs) remains unclear ...
Zhang M, Dong S, Rao W, Mei S, Hu G, Liu L, Wang Z, Tang J.   +7 more
europepmc   +2 more sources

Multidimensional cell-free DNA fragmentomics enables early detection of breast cancer. [PDF]

Breast Cancer Res
Background Cell-free DNA (cfDNA) fragmentomics represents a transformative approach for early breast cancer detection, offering significant potential to improve patient survival through timely intervention.
Yang L, An M, Song H, Zhang X, Wang M, Yang L, Wang X, Yang H, Hong X, Song Z.   +9 more
europepmc   +2 more sources

Seminal plasma cfDNA fragmentomics landscape delineates male infertility subtypes. [PDF]

Clin Epigenetics
Background While cell-free DNA (cfDNA) fragmentomics has transformed liquid biopsy applications in prenatal screening and oncology, its potential in male reproductive health remains unexplored.
Wu X, Meng F, Zhang H, Li Z, Zhao K.
europepmc   +2 more sources

GUIDE: a prospective cohort study for blood-based early detection of gastrointestinal cancers using targeted DNA methylation and fragmentomics sequencing. [PDF]

Mol Cancer
Background Gastrointestinal (GI) cancers are among the most prevalent and lethal malignancies worldwide. Early, non-invasive detection is essential for timely intervention and improved survival.
Huang A, Guo DZ, Su ZX, Zhong YS, Liu L, Xiong ZG, He DL, Yan B, Li QL, Feng Z, Wang WQ, Lu PX, He MJ, Qi ZP, Guo Q, Cheng JW, Zhang SY, Guo W, Li Q, Lin GY, Sun HC, Qiu SJ, He QY, Fan J, Goel A, Liu R, Jin G, Yang XR, Zhou J.   +28 more
europepmc   +2 more sources

Early detection, clinicopathological subtyping, and prognosis prediction for endometrial cancer patients using fragmentomics liquid biopsy assay. [PDF]

ESMO Open
Rao Q, Zhou H, Weng W, He Y, Li N, He P, Tang W, He M, Zhu X, Zhu D, Bao H, Wu X, Wang H, Lin Z, Zhang B.   +14 more
europepmc   +2 more sources

Cell-Free DNA Fragmentation Patterns in a Cancer Cell Line

Diagnostics, 2022
Unique bits of genetic, biological and pathological information occur in differently sized cell-free DNA (cfDNA) populations. This is a significant discovery, but much of the phenomenon remains to be explored. We investigated cfDNA fragmentation patterns
Vida Ungerer, Abel J. Bronkhorst, Carsten Uhlig, Stefan Holdenrieder   +3 more
doaj   +1 more source

Real‐time analysis of the cancer genome and fragmentome from plasma and urine cell‐free DNA using nanopore sequencing

EMBO Molecular Medicine, 2023
Cell‐free DNA (cfDNA) can be isolated and sequenced from blood and/or urine of cancer patients. Conventional short‐read sequencing lacks deployability and speed and can be biased for short cfDNA fragments.
Ymke van der Pol, Normastuti Adhini Tantyo, Nils Evander, Anouk E Hentschel, Birgit MM Wever, Jip Ramaker, Sanne Bootsma, Marieke F Fransen, Kristiaan J Lenos, Louis Vermeulen, Famke L Schneiders, Idris Bahce, Jakko A Nieuwenhuijzen, Renske DM Steenbergen, D Michiel Pegtel, Norbert Moldovan, Florent Mouliere   +16 more
doaj   +1 more source

Combining variant detection and fragment length analysis improves detection of minimal residual disease in postsurgery circulating tumour DNA of stage II–IIIA NSCLC patients

Molecular Oncology, 2022
Stage II–IIIA nonsmall cell lung cancer (NSCLC) patients receive adjuvant chemotherapy after surgery as standard‐of‐care treatment, even though only approximately 5.8% of patients will benefit.
Daan C. L. Vessies, Milou M. F. Schuurbiers, Vincent van derNoort, Irene Schouten, Theodora C. Linders, Mirthe Lanfermeijer, Kalpana L. Ramkisoensing, Koen J. Hartemink, Kim Monkhorst, Michel M. van denHeuvel, Daan van denBroek   +10 more
doaj   +1 more source

Fragmentomic cfDNA Patterns in Noninvasive Prenatal Testing and Beyond

Journal of Biomedicine and Translational Research, 2021
The release of fetoplacental cell-free DNA (cfDNA) into the maternal bloodstream opened up new avenues towards noninvasive prenatal testing (NIPT) for aneuploidies, hereditary DNA mutations and other pregnancy-related developmental disorders ...
Kavish Kohabir, Rob Wolthuis, Erik A. Sistermans   +2 more
doaj   +1 more source

Correspondence to editorial on "Aberrant fragmentomic features of circulating cell-free mitochondrial DNA enable early detection and prognosis prediction of hepatocellular carcinoma". [PDF]

Clin Mol Hepatol
Liu Y, Peng F, Wang S, Xing J.
europepmc   +2 more sources