Results 31 to 40 of about 907 (150)

Cell-free DNA Fragmentomics Assay to Discriminate the Malignancy of Breast Nodules and Evaluate Treatment Response. [PDF]

Genomics Proteomics Bioinformatics
Liu J, Li Y, Tang W, Qian T, Dai L, Jia Z, Cao H, Li C, Liu Y, Huang Y, Wu J, Ma D, Qiao G, Bao H, Chang S, Zhu D, Yang S, Wu X, Wu X, Xu H, Chen H, Shao Y, Wang X, Liu Z, Su J.   +24 more
europepmc   +2 more sources

Detection and characterization of lung cancer using cell-free DNA fragmentomes [PDF]

Nature Communications, 2021
AbstractNon-invasive approaches for cell-free DNA (cfDNA) assessment provide an opportunity for cancer detection and intervention. Here, we use a machine learning model for detecting tumor-derived cfDNA through genome-wide analyses of cfDNA fragmentation in a prospective study of 365 individuals at risk for lung cancer. We validate the cancer detection
Dimitrios Mathios, Jakob Sidenius Johansen, Stephen Cristiano, Jamie E. Medina, Jillian Phallen, Klaus R. Larsen, Daniel C. Bruhm, Noushin Niknafs, Leonardo Ferreira, Vilmos Adleff, Jia Yuee Chiao, Alessandro Leal, Michael Noe, James R. White, Adith S. Arun, Carolyn Hruban, Akshaya V. Annapragada, Sarah Østrup Jensen, Mai-Britt Worm Ørntoft, Anders Husted Madsen, Beatriz Carvalho, Meike de Wit, Jacob Carey, Nicholas C. Dracopoli, Tara Maddala, Kenneth C. Fang, Anne-Renee Hartman, Patrick M. Forde, Valsamo Anagnostou, Julie R. Brahmer, Remond J. A. Fijneman, Hans Jørgen Nielsen, Gerrit A. Meijer, Claus Lindbjerg Andersen, Anders Mellemgaard, Stig E. Bojesen, Robert B. Scharpf, Victor E. Velculescu   +37 more
openaire   +6 more sources

Aberrant fragmentomic features of circulating cell-free mitochondrial DNA enable early detection and prognosis prediction of hepatocellular carcinoma [PDF]

Clinical and Molecular Hepatology
Background/Aims Early detection and effective prognosis prediction in patients with hepatocellular carcinoma (HCC) provide an avenue for survival improvement, yet more effective approaches are greatly needed.
Yang Liu, Fan Peng, Siyuan Wang, Huanmin Jiao, Kaixiang Zhou, Wenjie Guo, Shanshan Guo, Miao Dang, Huanqin Zhang, Weizheng Zhou, Xu Guo, Jinliang Xing   +11 more
doaj   +1 more source

Fragmentomics of natural peptide structures

Biochemistry (Moscow), 2009
Natural fragmentation of peptide and other chemical structures is well known. They are a significant object of biochemical investigations. In this connection, the bases and determination are given for the notion of the "fragmentome" as a set of all fragments of a single substance, as well as for global fragmentome of all chemical components of living ...
openaire   +4 more sources

Exploration of cfDNA landscape in NIPT and clinical utilities of cfDNA based gene expression inference in prenatal diagnostics

Frontiers in Genetics
Cell-free DNA (cfDNA) is a dynamic biomarker reflecting the physiological state of the body. Its unique physical and biochemical properties, inherited from the tissue of origin, enable a wide range of clinical applications.
Ruo Jia, Jianjiang Zhu, Feng Zhang, Yangbo Sun, Bin Zhang, Yang Du, Hong Qi   +6 more
doaj   +1 more source

The emerging clinical relevance of cell-free DNA in lupus: from mechanistic insights to therapeutic opportunities

Frontiers in Immunology
Systemic lupus erythematosus (SLE) is a complex autoimmune disease often characterised by dysregulated immune responses to self-DNA. Emerging evidence highlights the role of cell-free DNA (cfDNA) in promoting immune activation in SLE.
Emily Jones, Kiki Cano-Gamez
doaj   +1 more source

Characterization of fragment sizes, copy number aberrations and 4‐mer end motifs in cell‐free DNA of hepatocellular carcinoma for enhanced liquid biopsy‐based cancer detection

Molecular Oncology, 2021
Circulating cell‐free DNA (cfDNA) fragmentomics, which encompasses the measurement of cfDNA length and short nucleotide motifs at the ends of cfDNA molecules, is an emerging field for cancer diagnosis.
Chao Jin, Xiaonan Liu, Wenyuan Zheng, Liping Su, Yang Liu, Xu Guo, Xiaoming Gu, Hongping Li, Bo Xu, Gang Wang, Jiyan Yu, Qiong Zhang, Dengke Bao, Shaogui Wan, Fei Xu, Xiaohuan Lai, Jiayun Liu, Jinliang Xing   +17 more
doaj   +1 more source

NICE: A Two‐Step Non‐Invasive Framework for Embryo cfDNA Read Enrichment and Quality Assessment

Advanced Science, EarlyView.
The non‐invasive NICE framework, built on an ensemble stacking machine learning model, prioritizes embryos by analyzing cell‐free DNA from spent culture medium. By integrating multimodal signals, including genomic and epigenetic profiles, this automated approach standardizes morphological assessment without human bias, paving the way for more precise ...
Xueya Zhou, Shu Ding, Zhenyi Zhang, Qiaoling Shangguan, Jie Qiao, Peijie Zhou, Yidong Chen   +6 more
wiley   +1 more source

Longitudinal profiling of hormone receptor positive, HER2 negative metastatic breast cancer through droplet digital PCR-based circulating tumor DNA fragmentomics. [PDF]

Transl Oncol
Foffano L, Franzoni A, Molteni E, Giudici F, Dri A, Basile D, Cucciniello L, Buriolla S, Noto C, Russo S, Nascimbeni E, Bolzonello S, Pastò B, Rossa SD, Allegri L, Bonotto M, Minisini AM, Belletti B, Damante G, Gerratana L, Puglisi F.   +20 more
europepmc   +2 more sources

Circulating Tumor DNA in Neurofibromatosis Type 1: Translating Molecular Discovery into Clinical Surveillance

Diagnostics
Neurofibromatosis type 1 (NF1) is a genetic tumor predisposition syndrome characterized by a substantial risk of developing peripheral nerve sheath tumors, including malignant peripheral nerve sheath tumors (MPNSTs), which occur in 8–13% of patients ...
Joanne Vanessa Vargas, Valeria Tosello, Giulia Pigato, Stefano Indraccolo, Federica Chiara   +4 more
doaj   +1 more source