Results 121 to 130 of about 907 (150)

Genomics and Epigenomics Approaches for the Quantification of Circulating Tumor DNA in Liquid Biopsy: Relevance of a Multimodal Strategy. [PDF]

Int J Mol Sci
De Paolis E, Perrucci A, Albertini Petroni G, Conca A, Corsi M, Urbani A, Minucci A.   +6 more
europepmc   +1 more source

Dissecting cell-free DNA fragmentation variation in tumors using cell line-derived xenograft mouse. [PDF]

PLoS One
Fu R, Su HA, Zhao Y, Tian Y, Chen H, Lu D.   +5 more
europepmc   +1 more source

Circulating tumor DNA-guided early detection and minimal residual disease monitoring in pancreatic and biliary cancers: evidence, barriers, and opportunities. [PDF]

World J Surg Oncol
Liu R, Yang Y, Hu Z, Fu Y.
europepmc   +1 more source

Early detection of urological tumors based on genomic characteristics of cell-free DNA fragments: a multi-center study. [PDF]

NPJ Precis Oncol
Zhang H, Huang C, Wei C, Zhou R, Wang C, Lu W, Wang Z, Li X, Chen S, Wang D, Ji J, Li Y, Yang R, Chen J, Hu Y, Wang F.   +15 more
europepmc   +1 more source

Cell-Free DNA Fragmentomics: The Novel Promising Biomarker

International Journal of Molecular Sciences, 2023
Cell-free DNA molecules are released into the plasma via apoptotic or necrotic events and active release mechanisms, which carry the genetic and epigenetic information of its origin tissues. However, cfDNA is the mixture of various cell fragments, and the efficient enrichment of cfDNA fragments with diagnostic value remains a great challenge for ...
Qinyu Ge, Min Pan, Yunfei Bai
exaly   +3 more sources

Emerging frontiers of cell-free DNA fragmentomics

Extracellular Vesicles and Circulating Nucleic Acids, 2022
Analysis of cell-free DNA (cfDNA) in the blood has shown promise for monitoring a variety of biological processes. Plasma cfDNA is a mixture comprising DNA molecules released from various bodily tissues, mediated by characteristic DNA fragmentations occurring during cell death.
Peiyong Jiang
exaly   +3 more sources

Fragmentomics features of ovarian cancer

International Journal of Cancer
AbstractOvarian cancer (OC) is a major cause of cancer mortality in women worldwide. Due to the occult onset of OC, its nonspecific clinical symptoms in the early phase, and a lack of effective early diagnostic tools, most OC patients are diagnosed at an advanced stage.
Lei Li, Jing Wang, Huanwen Wu
exaly   +3 more sources

Cell-free DNA fragmentomics in cancer

Cancer Cell
The analysis of cell-free DNA (cfDNA) fragmentation patterns, known as "fragmentomics," has opened new opportunities in noninvasive cancer diagnostics. Due to its close relationships with genomic organization and cell death, cfDNA fragmentomics lies at the intersection of many aspects of cancer biology, including epigenetic dysregulation ...
Peiyong Jiang, Y M Dennis Lo
exaly   +3 more sources

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Epigenetics, fragmentomics, and topology of cell-free DNA in liquid biopsies

Science, 2021
Enhancing liquid biopsies Liquid biopsies, analyses of cell-free DNA that circulates in the blood, can be used in prenatal testing, oncology, and to monitor organ transplant recipients. Lo et al. review the nongenetic information that can be gleaned from analyses of cell-free DNA, which offers additional ...
Y. M. Dennis Lo, Diana S. C. Han, Peiyong Jiang, Rossa W. K. Chiu   +3 more
openaire   +2 more sources