Results 51 to 60 of about 1,208 (179)

Aberrant fragmentomic features of circulating cell-free mitochondrial DNA enable early detection and prognosis prediction of hepatocellular carcinoma [PDF]

Clinical and Molecular Hepatology
Background/Aims Early detection and effective prognosis prediction in patients with hepatocellular carcinoma (HCC) provide an avenue for survival improvement, yet more effective approaches are greatly needed.
Yang Liu, Fan Peng, Siyuan Wang, Huanmin Jiao, Kaixiang Zhou, Wenjie Guo, Shanshan Guo, Miao Dang, Huanqin Zhang, Weizheng Zhou, Xu Guo, Jinliang Xing   +11 more
doaj   +1 more source

Exploration of cfDNA landscape in NIPT and clinical utilities of cfDNA based gene expression inference in prenatal diagnostics

Frontiers in Genetics
Cell-free DNA (cfDNA) is a dynamic biomarker reflecting the physiological state of the body. Its unique physical and biochemical properties, inherited from the tissue of origin, enable a wide range of clinical applications.
Ruo Jia, Jianjiang Zhu, Feng Zhang, Yangbo Sun, Bin Zhang, Yang Du, Hong Qi   +6 more
doaj   +1 more source

NICE: A Two‐Step Non‐Invasive Framework for Embryo cfDNA Read Enrichment and Quality Assessment

Advanced Science, EarlyView.
The non‐invasive NICE framework, built on an ensemble stacking machine learning model, prioritizes embryos by analyzing cell‐free DNA from spent culture medium. By integrating multimodal signals, including genomic and epigenetic profiles, this automated approach standardizes morphological assessment without human bias, paving the way for more precise ...
Xueya Zhou, Shu Ding, Zhenyi Zhang, Qiaoling Shangguan, Jie Qiao, Peijie Zhou, Yidong Chen   +6 more
wiley   +1 more source

Multimodal analysis of methylomics and fragmentomics in plasma cell-free DNA for multi-cancer early detection and localization

, 2023
Despite their promise, circulating tumor DNA (ctDNA)-based assays for multi-cancer early detection face challenges in test performance, due mostly to the limited abundance of ctDNA and its inherent variability.
Boi Hoan Huu Phan, Thi Thanh Do, Le Son Tran, Hung Sang Tang, Giang Thi Huong Nguyen, Ngan Chau Tran, Thanh Xuan Jasmine, Minh Nguyen Nguyen, Minh Long Duong, Duc Huy Tran, Hoai-Nghia Nguyen, Thi Hue Hanh Nguyen, Trung Kien Le, Minh-Duy Phan, Thanh Dang Nguyen, Minh Triet Le, Van Thinh Cao, Vu Tuan Anh Nguyen, Thuy Thi Thu Tran, Le Minh Quoc Ho, Thi Minh Thu Tran, Minh Phong Le, Anh Nhu Nguyen, Thanh Hai Phan, Van Chu Nguyen, Thuy Nguyen Doan, Quang Dat Tran, Thanh-Thuy Thi Do, Thanh Dat Nguyen, Thi Thu Thuy Pham, Hoa Giang, Trung Hieu Tran, Van Vu Kim, Tan Dat Ho, Huu Thinh Nguyen, The Anh Pham, Trong Hieu Nguyen, Thanh Nhan Vo Nguyen, Truong Vinh Ngoc Pham, Nhu Nhat Tan Doan, Thi Mong Quynh Pham, Trieu Vu Nguyen, Trinh Ngoc An Le, Thi Tuong Vi Van, Quang Thong Dang, Viet Hai Nguyen, Thuy Trang Tran, Vu Uyen Tran, Anh Minh Tran, Thanh Huong Thi Tran, Dung Thai Bieu Phu, Thi Trang Tran, Duy Long Vo, Thi Huong Thoang Nai, Duy Sinh Nguyen, Van Thien Chi Nguyen, Thi Van Phan, Hoai Phuong Thi Bach, Dac Ho Vo, My Hoang Truong, Hong-Dang Luu Nguyen, Thi Loan Vo, Bao Toan Nguyen, Le Anh Khoa Huynh, Dinh Kiet Truong   +64 more
core   +1 more source

Circulating Tumor DNA in Neurofibromatosis Type 1: Translating Molecular Discovery into Clinical Surveillance

Diagnostics
Neurofibromatosis type 1 (NF1) is a genetic tumor predisposition syndrome characterized by a substantial risk of developing peripheral nerve sheath tumors, including malignant peripheral nerve sheath tumors (MPNSTs), which occur in 8–13% of patients ...
Joanne Vanessa Vargas, Valeria Tosello, Giulia Pigato, Stefano Indraccolo, Federica Chiara   +4 more
doaj   +1 more source

Characterization of fragment sizes, copy number aberrations and 4‐mer end motifs in cell‐free DNA of hepatocellular carcinoma for enhanced liquid biopsy‐based cancer detection

Molecular Oncology, 2021
Circulating cell‐free DNA (cfDNA) fragmentomics, which encompasses the measurement of cfDNA length and short nucleotide motifs at the ends of cfDNA molecules, is an emerging field for cancer diagnosis.
Chao Jin, Xiaonan Liu, Wenyuan Zheng, Liping Su, Yang Liu, Xu Guo, Xiaoming Gu, Hongping Li, Bo Xu, Gang Wang, Jiyan Yu, Qiong Zhang, Dengke Bao, Shaogui Wan, Fei Xu, Xiaohuan Lai, Jiayun Liu, Jinliang Xing   +17 more
doaj   +1 more source

Sizing and concentration analysis of cfDNA using Biabooster technology: Results from a prospective plasma‐based collection of 77 patients with locally advanced unresectable esophageal cancer

International Journal of Cancer, EarlyView.
What's New? This study introduces a novel approach for detecting locally advanced esophageal carcinoma using cell‐free DNA (cfDNA) analysis through a highly sensitive fragmentome assay. Unlike traditional sequencing‐based methods that are limited by the absence of specific mutations in esophageal tumors, our method offers an alternative by quantifying ...
Anouchka Modesto, Sophie Gibert, Caroline Delmas, David Tougeron, Amaury Paumier, Alexandre Taillez, Samuel Le Sourd, Delphine Argo Leignel, Philippe Ronchin, Ariane Darut Jouve, Véronique Vendrely, Olivier Riou, Jérôme Martin‐Babau, Thomas Leroy, Laurent Quéro, Naïma Hanoun, Pierre Cordelier, Veronica Pezzella, Jean Pierre Delord, Rosine Guimbaud, Elizabeth Moyal, Catherine Seva   +21 more
wiley   +1 more source

Functional footprints of homologous recombination deficiency in prostate cancer revealed by ctDNA fragmentation and transcription factor accessibility. [PDF]

Br J Cancer
BACKGROUND: Homologous recombination deficiency (HRD) is a predictive biomarker for response to PARP inhibitors and platinum-based therapies in prostate cancer (PCa).
Vlachos G, Moser T, Lazzeri I, Moser MJ, Glawitch L, Bauernhofer ET, Eberhard A, Beichler C, Sadeghi H, Blatterer J, Kühberger S, Monsberger N, Terbuch A, Kashofer K, Geigl JB, Bauernhofer T, Heitzer E.   +16 more
europepmc   +2 more sources

Multi-signal cell-free DNA analysis for cancer detection [PDF]

, 2023
In this thesis, we explored the potential of circulating cell-free DNA (cfDNA) metrics for non-invasive cancer detection and therapy response prediction, leveraging whole genome sequencing (WGS) data. Our research was divided into two parts.
van der Pol, Ymke
core   +1 more source

Saliva Liquid Biopsy for Detection of Oral and Systemic Diseases

Journal of Periodontal Research, EarlyView.
This Review summarizes and discusses the biological foundations and major classes of salivary biomarkers, outlines collection methods and analytical protocols for saliva‐based liquid biopsy, and technological convergences driven by multi‐omics approaches, artificial intelligence, and point‐of‐care devices in the application of oral and systemic ...
Irene Choi, Aaron Zander, Bradley Chan, Leila Syedmoradi, Dev Trivedi, Karolina Elżbieta Kaczor‐Urbanowicz, Fang Wei, Neeti Swarup, Trinity Chan, Mario Romandini, David T. W. Wong   +10 more
wiley   +1 more source