Results 21 to 30 of about 1,072 (154)

From detection to action: ctDNA-MRD surveillance and translational strategies in early breast cancer [PDF]

Frontiers in Oncology
Recurrence remains a major cause of mortality in early breast cancer (EBC), and conventional follow-up often identifies relapse only after clinically detectable disease has emerged. Circulating tumor DNA–based minimal residual disease (ctDNA-MRD) testing
Jing Feng, Yujun Tong, Zhen Zhang, Ye Zhang   +3 more
doaj   +2 more sources

Epigenomic modifications define chromatin states to regulate cell-free DNA fragmentomics [PDF]

Nature Communications
Plasma cell-free DNA (cfDNA) fragmentomics offer promising cancer biomarkers, but their molecular regulation remains elusive. Here, we investigate the role of epigenomic modifications in cfDNA fragmentation.
Fanglei Gong, Yuqi Pan, Huizhen Lin, Yunyun An, Mengqi Yang, Xiaoyi Liu, Yunxia Bai, Zhenyu Zhang, Bianbian Tang, Kun Zhang, Xin Zhao, Yu Zhao, Changzheng Du, Xuetong Shen, Kun Sun   +14 more
doaj   +2 more sources

Cell-free nucleic acid fragmentomics: A non-invasive window into cellular epigenomes

Translational Oncology
Clinical genomic profiling of cell-free nucleic acids (e.g. cell-free DNA or cfDNA) from blood and other body fluids has ushered in a new era in non-invasive diagnostics and treatment monitoring strategies for health conditions and diseases such as ...
Subhajyoti De
exaly   +3 more sources

A cfDNA fragmentomics classifier for noninvasive differentiation of benign and malignant renal masses [PDF]

Molecular Biomedicine
Noninvasive differentiation of malignant and benign renal masses remains a major clinical challenge, particularly for radiologically indeterminate lesions.
Linfei Li, Cong Wang, Song Wang, Jun Zheng, Jian Fu, Ling Wei, Juan Shen, Yuwei Li, Xinyue Hong, Chunman Wu, Wei Chen, Wei Gong, Yongquan Wang   +12 more
doaj   +2 more sources

The emerging clinical relevance of cell-free DNA in lupus: from mechanistic insights to therapeutic opportunities [PDF]

Frontiers in Immunology
Systemic lupus erythematosus (SLE) is a complex autoimmune disease often characterised by dysregulated immune responses to self-DNA. Emerging evidence highlights the role of cell-free DNA (cfDNA) in promoting immune activation in SLE.
Emily Jones, Kiki Cano-Gamez
doaj   +2 more sources

Fragmenting the future with FLARE: a comprehensive fragmentomics pipeline based on long-read nanopore sequencing [PDF]

Frontiers in Genetics
PurposeCell-free DNA (cfDNA) fragmentation patterns carry biological information beyond fragment length, revealing nuclease activity, chromatin organization, and tissue of origin.
Marica Ficorilli, Marta Lucchetta, Deborah Lenoci, Ilenia Rolli, Nicole Farina, Valentina Cristofaro, Lorenzo Giannini, Arianna Ottini, Alberto Deganello, Alberto Deganello, Stefano Cavalieri, Stefano Cavalieri, Lisa Licitra, Lisa Licitra, Loris De Cecco   +14 more
doaj   +2 more sources

Multidimensional roles of cfDNA fragmentomics in preeclampsia: from placental hypoxia and TLR9 inflammation to clinical risk stratification

Frontiers in Medicine
Cell-free DNA (cfDNA) has emerged as a pivotal biomarker for predicting preeclampsia (PE), a multisystem syndrome characterized by placental hypoperfusion and systemic inflammation.
Ziyi Guo
exaly   +3 more sources

Fragmentomics of urinary cell-free DNA in nuclease knockout mouse models.

PLoS Genetics, 2022
Urinary cell-free DNA (ucfDNA) is a potential biomarker for bladder cancer detection. However, the biological characteristics of ucfDNA are not well understood.
Meihui Chen, Rebecca W Y Chan, Peter P H Cheung, Meng Ni, Danny K L Wong, Ze Zhou, Mary-Jane L Ma, Liangbo Huang, Xinzhou Xu, Wing-Shan Lee, Guangya Wang, Kathy O Lui, W K Jacky Lam, Jeremy Y C Teoh, Chi-Fai Ng, Peiyong Jiang, K C Allen Chan, Rossa W K Chiu, Y M Dennis Lo   +18 more
doaj   +3 more sources

Multidimensional cell-free DNA fragmentomics enables early detection of breast cancer [PDF]

Breast Cancer Research
Background Cell-free DNA (cfDNA) fragmentomics represents a transformative approach for early breast cancer detection, offering significant potential to improve patient survival through timely intervention.
Lixian Yang, Mengyang An, Heng song, Xuan Zhang, Meiqi Wang, Liu Yang, Xinle Wang, Hua Yang, Xinyue Hong, Zhenchuan Song   +9 more
doaj   +2 more sources

A multi-center study for colorectal cancer early detection in high-risk disease patients using cell-free fragmentomics assay

Cancer Cell International
Background Early detection of colorectal cancer (CRC) is crucial for improving patient survival. This innovative multi-center study aims to develop a non-invasive blood-based assay using cell-free DNA (cfDNA) fragmentomics to differentiate CRC from ...
Bing Gu, Jierong Chen, Deqing Wu
exaly   +2 more sources