Results 51 to 60 of about 1,183 (178)
Profiling disease and tissue-specific epigenetic signatures in cell-free DNA
Journal of Laboratory Medicine, 2022 Programmed cell death, accidental cell degradation and active extrusion constantly lead to the release of DNA fragments into human body fluids from virtually all cell and tissue types.
Oberhofer Angela +3 more
doaj +1 more source
Detecting Liver Cancer Using Cell-Free DNA Fragmentomes
Cancer Discovery, 2022 Abstract Liver cancer is a major cause of cancer mortality worldwide. Screening individuals at high risk, including those with cirrhosis and viral hepatitis, provides an avenue for improved survival, but current screening methods are inadequate.
Zachariah H. Foda +20 more
openaire +2 more sources
Aberrant fragmentomic features of circulating cell-free mitochondrial DNA enable early detection and prognosis prediction of hepatocellular carcinoma [PDF]
Clinical and Molecular HepatologyBackground/Aims Early detection and effective prognosis prediction in patients with hepatocellular carcinoma (HCC) provide an avenue for survival improvement, yet more effective approaches are greatly needed.
Yang Liu +11 more
doaj +1 more source
Detection and characterization of lung cancer using cell-free DNA fragmentomes [PDF]
Nature Communications, 2021 AbstractNon-invasive approaches for cell-free DNA (cfDNA) assessment provide an opportunity for cancer detection and intervention. Here, we use a machine learning model for detecting tumor-derived cfDNA through genome-wide analyses of cfDNA fragmentation in a prospective study of 365 individuals at risk for lung cancer. We validate the cancer detection
Dimitrios Mathios +37 more
openaire +6 more sources
Fragmentomics of natural peptide structures
Biochemistry (Moscow), 2009 Natural fragmentation of peptide and other chemical structures is well known. They are a significant object of biochemical investigations. In this connection, the bases and determination are given for the notion of the "fragmentome" as a set of all fragments of a single substance, as well as for global fragmentome of all chemical components of living ...
openaire +4 more sources
Frontiers in GeneticsCell-free DNA (cfDNA) is a dynamic biomarker reflecting the physiological state of the body. Its unique physical and biochemical properties, inherited from the tissue of origin, enable a wide range of clinical applications.
Ruo Jia +6 more
doaj +1 more source
The circulating cell-free DNA landscape in sepsis is dominated by impaired liver clearance
Cell GenomicsSummary: Circulating cell-free DNA (cfDNA) is a promising molecular biomarker, but its role in severe infection is unclear. Here, we profile cfDNA from sepsis patients and controls, demonstrating a 41-fold increase during disease.
Kiki Cano-Gamez +9 more
doaj +1 more source
Functional footprints of homologous recombination deficiency in prostate cancer revealed by ctDNA fragmentation and transcription factor accessibility. [PDF]
Br J CancerBACKGROUND: Homologous recombination deficiency (HRD) is a predictive biomarker for response to PARP inhibitors and platinum-based therapies in prostate cancer (PCa).
Vlachos G +16 more
europepmc +2 more sources
NICE: A Two‐Step Non‐Invasive Framework for Embryo cfDNA Read Enrichment and Quality Assessment
Advanced Science, EarlyView.The non‐invasive NICE framework, built on an ensemble stacking machine learning model, prioritizes embryos by analyzing cell‐free DNA from spent culture medium. By integrating multimodal signals, including genomic and epigenetic profiles, this automated approach standardizes morphological assessment without human bias, paving the way for more precise ...
Xueya Zhou +6 more
wiley +1 more source
, 2023 Despite their promise, circulating tumor DNA (ctDNA)-based assays for multi-cancer early detection face challenges in test performance, due mostly to the limited abundance of ctDNA and its inherent variability.
Boi Hoan Huu Phan +64 more
core +1 more source