Results 41 to 50 of about 59,619 (217)
Ribosomal frameshifting in yeast viruses [PDF]
Yeast, 1995 AbstractProper maintenance of translational reading frame by ribosomes is essential for cell growth and viability. In the last 10 years it has been shown that a number of viruses induce ribosomes to shift reading frame in order to regulate the expression of gene products having enzymatic functions. Studies on ribosomal frameshifting in viruses of yeast
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Loss of N1-methylation of G37 in tRNA induces ribosome stalling and reprograms gene expression
eLife, 2021 N1-methylation of G37 is required for a subset of tRNAs to maintain the translational reading-frame. While loss of m1G37 increases ribosomal +1 frameshifting, whether it incurs additional translational defects is unknown.
Isao Masuda +7 more
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Transcription-translation coupling: direct interactions of RNA polymerase with ribosomes and ribosomal subunits. [PDF]
, 2017 In prokaryotes, RNA polymerase and ribosomes can bind concurrently to the same RNA transcript, leading to the functional coupling of transcription and translation.
Blaha, Gregor M +9 more
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Altering SARS Coronavirus Frameshift Efficiency Affects Genomic and Subgenomic RNA Production
Viruses, 2013 In previous studies, differences in the amount of genomic and subgenomic RNA produced by coronaviruses with mutations in the programmed ribosomal frameshift signal of ORF1a/b were observed.
Ewan P. Plant +4 more
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Characterization of Ribosomal Frameshifting in Theiler's Murine Encephalomyelitis Virus. [PDF]
, 2015 Theiler's murine encephalomyelitis virus (TMEV) is a member of the genus Cardiovirus in the Picornaviridae, a family of positive-sense single-stranded RNA viruses. Previously, we demonstrated that in the related cardiovirus, Encephalomyocarditis virus, a
Bell, Susanne +9 more
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Identification of the nature of reading frame transitions observed in prokaryotic genomes [PDF]
, 2013 Our goal was to identify evolutionary conserved frame transitions in protein coding regions and to uncover an underlying functional role of these structural aberrations.
Antonov, Ivan +4 more
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Synergetic regulation of translational reading-frame switch by ligand-responsive RNAs in mammalian cells [PDF]
, 2014 Distinct translational initiation mechanisms between prokaryotes and eukaryotes limit the exploitation of prokaryotic riboswitch repertoire for regulatory RNA circuit construction in mammalian application.
Chang, K.-Y., Hsu, H.-T., Lin, Y.-H.
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Programmed ribosomal frameshifting: Much ado about knotting! [PDF]
Proceedings of the National Academy of Sciences, 1999 We know little about the global contribution that recoding makes to the complexity of proteomes. It could be that many mRNAs encode, in addition to their standard products, minor products that so far would have escaped detection. These products are likely to have distinct functions and contribute to the biological complexity of the proteome.
S L, Alam, J F, Atkins, R F, Gesteland
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Biology Direct, 2017 Background Programmed ribosomal frameshifting (PRF) is a gene expression mechanism which enables the translation of two N-terminally coincident, C-terminally distinct protein products from a single mRNA.
Adam M. Dinan +2 more
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Viruses, 2021 Many viruses, especially RNA viruses, utilize programmed ribosomal frameshifting and/or stop codon readthrough in their expression, and in the decoding of a few a UGA is dynamically redefined to specify selenocysteine.
John F. Atkins +3 more
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