Results 31 to 40 of about 59,619 (217)
KnotInFrame: prediction of −1 ribosomal frameshift events [PDF]
Nucleic Acids Research, 2008 Programmed -1 ribosomal frameshift (-1 PRF) allows for alternative reading frames within one mRNA. First found in several viruses, it is now believed to exist in all kingdoms of life. Strong stimulators for -1 PRF are a heptameric slippery site and an RNA pseudoknot.
Theis, Corinna +2 more
openaire +3 more sources
The energy landscape of −1 ribosomal frameshifting [PDF]
Science Advances, 2020 During translation, the presence of an mRNA structure prolongs a ribosomal state favorable to spontaneous frameshifting.
Junhong Choi +3 more
openaire +3 more sources
Nature Communications, 2021 The RNA pseudoknot of SARS-CoV-2 promotes -1 programmed ribosomal frameshifting. Here the authors use single molecule force spectroscopy to study the folding of this pseudoknot, showing that it forms at least two different pseudoknot conformers with ...
Krishna Neupane +8 more
doaj +1 more source
A Novel Frameshifting Inhibitor Having Antiviral Activity against Zoonotic Coronaviruses
Viruses, 2021 Recent outbreaks of zoonotic coronaviruses, such as Middle East respiratory syndrome coronavirus (MERS-CoV) and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), have caused tremendous casualties and great economic shock.
Dae-Gyun Ahn +9 more
doaj +1 more source
Monovalent ions modulate the flux through multiple folding pathways of an RNA pseudoknot [PDF]
, 2017 The functions of RNA pseudoknots (PKs), which are minimal tertiary structural motifs and an integral part of several ribozymes and ribonucleoprotein complexes, are determined by their structure, stability and dynamics.
Ansari, Anjum +7 more
core +3 more sources
HCV IRES manipulates the ribosome to promote the switch from translation initiation to elongation. [PDF]
, 2013 The internal ribosome entry site (IRES) of the hepatitis C virus (HCV) drives noncanonical initiation of protein synthesis necessary for viral replication.
A Ben-Shem +68 more
core +1 more source
Structural and molecular basis for Cardiovirus 2A protein as a viral gene expression switch
Nature Communications, 2021 Many RNA viruses employ programmed –1 ribosomal frameshifting (PRF) to expand their coding capacity and optimize production of viral proteins. Here, the authors report structural and biophysical analysis of protein 2A from a cardiovirus, with insights ...
Chris H. Hill +7 more
doaj +1 more source
Programmable modulation of ribosomal frameshifting by mRNA targeting CRISPR-Cas12a system
iScience, 2023 Summary: Minus 1 programmed ribosomal frameshifting (−1 PRF) is a conserved translational regulation event essential for critical biological processes, including the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) replication.
Shih-Hong Huang +4 more
doaj +1 more source
Viruses, 2021 The product of the interferon-stimulated gene C19orf66, Shiftless (SHFL), restricts human immunodeficiency virus replication through downregulation of the efficiency of the viral gag/pol frameshifting signal.
Sawsan Napthine +3 more
doaj +1 more source
Novel viruses of the genus Amalgavirus from crown imperial Fritillaria imperialis transcriptome [PDF]
Journal of Crop Protection, 2023 In an in silico investigation, genome sequences of three RNA viruses were identified in the crown imperial Fritillaria imperialis L. transcriptome dataset.
Sajad Astaraki, Masoud Shams-bakhsh
doaj +1 more source