Results 21 to 30 of about 59,619 (217)
A three-stemmed mRNA pseudoknot in the SARS coronavirus frameshift signal. [PDF]
PLoS Biology, 2005 A wide range of RNA viruses use programmed -1 ribosomal frameshifting for the production of viral fusion proteins. Inspection of the overlap regions between ORF1a and ORF1b of the SARS-CoV genome revealed that, similar to all coronaviruses, a programmed -
Ewan P Plant +5 more
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A drug screening toolkit based on the –1 ribosomal frameshifting of SARS-CoV-2
Heliyon, 2020 The –1 ribosomal frameshifting is vital for the translation of the open reading frame (ORF)1b in SARS-CoV-2. The products of ORF1b participate in viral replication. Therefore, changing the frameshift frequency reduces the survival of the virus.
Yanqiong Chen +8 more
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Bacterial riboproteogenomics : the era of N-terminal proteoform existence revealed [PDF]
, 2020 With the rapid increase in the number of sequenced prokaryotic genomes, relying on automated gene annotation became a necessity. Multiple lines of evidence, however, suggest that current bacterial genome annotations may contain inconsistencies and are ...
Fijalkowska, Daria +3 more
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High-throughput interrogation of programmed ribosomal frameshifting in human cells
Nature Communications, 2020 Programmed ribosomal frameshifting—the slippage of the ribosome to an alternative frame — is critical for viral replication and cellular processes.
Martin Mikl, Yitzhak Pilpel, Eran Segal
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An astrovirus frameshift signal induces ribosomal frameshifting in vitro [PDF]
Archives of Virology, 1995 Expression of the astrovirus RNA-dependent RNA polymerase has been hypothesized to be regulated by (-1) ribosomal frameshifting. Sequence analysis of the 70 nucleotide region between open reading frames 1a and 1b indicates the presence of a shifty heptamer consensus sequence and downstream sequences that may be needed for ribosomal frameshifting.
Lewis, T. L., Matsui, S. M.
openaire +2 more sources
Thinking Outside the Frame: Impacting Genomes Capacity by Programmed Ribosomal Frameshifting
Frontiers in Molecular Biosciences, 2022 Translation facilitates the transfer of the genetic information stored in the genome via messenger RNAs to a functional protein and is therefore one of the most fundamental cellular processes.
Ricarda J. Riegger +3 more
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Nature Communications, 2021 Programmed ribosomal frameshifting (PRF) occurs in many viruses including SARS-CoV-2 to allow the translation of multiple proteins from a single transcript.
Matthias M. Zimmer +8 more
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Deciphering Ribosomal Frameshifting Dynamics [PDF]
Biophysical Journal, 2012 Ribosomes programmed by specific messenger RNA (mRNA) sequence elements can switch translation reading frames and synthesize different polypeptides from a single template. The Escherichia coli dnaX mRNA encodes two DNA polymerase III subunits, τ and γ, synthesized from 0-frame and probabilistic −1-slip across the slippery sequence: AAAAAAG.
Yan, Shannon +5 more
openaire +2 more sources
Active role of elongation factor G in maintaining the mRNA reading frame during translation. [PDF]
, 2019 During translation, the ribosome moves along the mRNA one codon at a time with the help of elongation factor G (EF-G). Spontaneous changes in the translational reading frame are extremely rare, yet how the precise triplet-wise step is maintained is not ...
Belardinelli, R. +5 more
core +2 more sources
Computational and Structural Biotechnology Journal, 2021 Programmed −1 ribosomal frameshifting (−1 PRF) is a translation mechanism that regulates the relative expression level of two proteins encoded on the same messenger RNA (mRNA).
Kai-Chun Chang, Jin-Der Wen
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