Thermodynamic control of −1 programmed ribosomal frameshifting [PDF]
Nature Communications, 2019 Programmed ribosomal frameshifting (PRF) is an alternative translation strategy that causes controlled slippage of the ribosome along the mRNA, changing the sequence of the synthesized protein.
Lars V. Bock +5 more
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Ribosomal frameshifting used in influenza A virus expression occurs within the sequence UCC_UUU_CGU and is in the +1 direction [PDF]
Open Biology, 2012 Programmed ribosomal frameshifting is used in the expression of many virus genes and some cellular genes. In eukaryotic systems, the most well-characterized mechanism involves –1 tandem tRNA slippage on an X_XXY_YYZ motif.
A. E. Firth +9 more
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On programmed ribosomal frameshifting: the alternative proteomes [PDF]
Frontiers in Genetics, 2012 Frameshifting results from two main mechanisms: genomic insertions or deletions (indels) or programmed ribosomal frameshifting. Whereas indels can disrupt normal protein function, programmed ribosomal frameshifting can result in dual-coding genes, each ...
Robin eKetteler
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Protein-inducible ribosomal frameshifting enables programmable translational control for genetic circuit design in Escherichia coli [PDF]
Journal of Biological EngineeringBackground Programmed ribosomal frameshifting (PRF) is a translational mechanism that enables the ribosome to shift reading frames and access alternative coding sequences.
Seongho Hong +3 more
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Evolutionary origin of the frameshift sites in the ribosomal frameshifting genes of Euplotes [PDF]
BMC GenomicsBackground Programmed ribosome frameshifting is a translational recoding event in which ribosomes slip forward or backward along the mRNA. Although genes utilizing programmed ribosomal frameshifting for their expression have been found in most organisms,
Ruan-lin Wang +5 more
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An RNA modification prevents extended codon-anticodon interactions from facilitating +1 frameshifting [PDF]
Nature CommunicationsRNA post-transcriptional modifications act by stabilizing the functional conformations of RNA. While their role in messenger RNA (mRNA) decoding is well established, it is less clear how transfer RNA (tRNA) modifications outside the anticodon contribute ...
Evelyn M. Kimbrough +9 more
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Accounting for Programmed Ribosomal Frameshifting in the Computation of Codon Usage Bias Indices [PDF]
G3: Genes, Genomes, Genetics, 2018 Experimental evidence shows that synonymous mutations can have important consequences on genetic fitness. Many organisms display codon usage bias (CUB), where synonymous codons that are translated into the same amino acid appear with distinct frequency ...
Victor Garcia +2 more
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Protein-directed ribosomal frameshifting temporally regulates gene expression [PDF]
Nature Communications, 2017 Programmed −1 ribosomal frameshifting (−1 PRF) is a mechanism whereby specific signals within mRNAs direct ribosomes to shift into an alternative reading frame.
Sawsan Napthine +6 more
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The role of chikungunya virus capsid-viral RNA interactions in programmed ribosomal frameshifting [PDF]
Journal of VirologyChikungunya virus (CHIKV) is a globally significant arthropod-borne virus that causes outbreaks in tropical and subtropical regions and is rapidly expanding in geographical range.
Jordan A. Farrington +2 more
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Stem loop binding protein promotes SARS-CoV-2 replication via -1 programmed ribosomal frameshifting [PDF]
Signal Transduction and Targeted TherapyThe -1 programmed ribosomal frameshifting (-1 PRF) in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is crucial for keeping the balance between pp1a and pp1ab polyproteins.
Tanxiu Chen +11 more
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