Results 41 to 50 of about 38,009 (292)

Tolfenpyrad displays Francisella-targeted antibiotic activity that requires an oxidative stress response regulator for sensitivity

Microbiology Spectrum, 2023
Francisella tularensis is a highly infectious Gram-negative bacterial pathogen capable of animal-to-human transmission. Due to its remarkable pathogenicity and potential for widespread public health impact, F.
Ashley Clarke, Isabelle M. Llabona, Nimra Khalid, Danielle Hulvey, Alexis Irvin, Nicole Adams, Henry S. Heine, Aria Eshraghi   +7 more
doaj   +1 more source

Human tularemia in Italy. Is it a re-emerging disease? [PDF]

, 2014
In order to evaluate whether tularemia is re-emerging in Italy, data on mortality and morbidity (obtained by the National Institute of Statistics; ISTAT), Italian cases described in the scientific literature and data concerning hospitalizations for ...
A., Bella, A., Nusca, D'Alessandro, Daniela, E., Funari, Napoli, Christian   +4 more
core   +1 more source

Human caspase-4 detects tetra-acylated LPS and cytosolic Francisella and functions differently from murine caspase-11

Nature Communications, 2018
Caspase-4/5 in humans and caspase-11 in mice bind hexa-acylated lipid A, the lipid moeity of lipopolysaccharide (LPS), to induce the activation of non-canonical inflammasome.
Brice Lagrange, Sacha Benaoudia, Pierre Wallet, F. Magnotti, Angélina Provost, Fanny Michal, Amandine Martin, F. Di Lorenzo, B. Py, A. Molinaro, T. Henry   +10 more
semanticscholar   +1 more source

Reclassification of Francisella noatunensis subsp. orientalis Ottem et al. 2009 as Francisella orientalis sp. nov., Francisella noatunensis subsp. chilensis subsp. nov. and emended description of Francisella noatunensis.

International Journal of Systematic and Evolutionary Microbiology, 2020
Francisella noatunensis is a fastidious facultative intracellular bacterial pathogen that causes 'piscine francisellosis', a serious disease affecting both marine and fresh water farmed and wild fish worldwide. Currently two F. noatunensis subspecies are
J. G. Ramírez-Paredes, Pär Larsson, K. Thompson, D. Penman, H. Busse, C. Öhrman, A. Sjödin, E. Soto, R. Richards, A. Adams, D. Colquhoun   +10 more
semanticscholar   +1 more source

Francisella tularensis subsp. tularensis induces a unique pulmonary inflammatory response: role of bacterial gene expression in temporal regulation of host defense responses. [PDF]

PLoS ONE, 2013
Pulmonary exposure to Francisella tularensis is associated with severe lung pathology and a high mortality rate. The lack of induction of classical inflammatory mediators, including IL1-β and TNF-α, during early infection has led to the suggestion that F.
Kathie-Anne Walters, Rachael Olsufka, Rolf E Kuestner, Ji Hoon Cho, Hong Li, Gregory A Zornetzer, Kai Wang, Shawn J Skerrett, Adrian Ozinsky   +8 more
doaj   +1 more source

Regulation of virulence in Francisella tularensis by small non-coding RNAs [PDF]

, 2011
Using a cDNA cloning and sequencing approach we have shown that Francisella tularensis expresses homologues of several small RNAs (sRNAs) that are well-conserved among diverse bacteria.
Alain Charbit, Eric Frapy, Guillaume Postic, Iharilalao Dubail, Jonathan Livny, Karin L. Meibom, Marion Dupuis   +6 more
core   +2 more sources

Differentiation of Francisella tularensis Subspecies and Subtypes

Journal of Clinical Microbiology, 2020
The highly infectious and zoonotic pathogen Francisella tularensis is the etiologic agent of tularemia, a potentially fatal disease if untreated. Despite the high average nucleotide identity, which is >99.2% for the virulent subspecies and >98% for all ...
Marilynn A. Larson, K. Sayood, Amanda M. Bartling, Jennifer R. Meyer, C. Starr, James Baldwin, M. Dempsey   +6 more
semanticscholar   +1 more source

Whole genome sequencing of the fish pathogen Francisella noatunensis subsp. orientalis Toba04 gives novel insights into Francisella evolution and pathogenecity

BMC Genomics, 2012
Background Francisella is a genus of gram-negative bacterium highly virulent in fishes and human where F. tularensis is causing the serious disease tularaemia in human.
Sridhar Settu, Sharma Animesh, Kongshaug Heidi, Nilsen Frank, Jonassen Inge   +4 more
doaj   +1 more source

Inflammasomes: caspase-1-activating platforms with critical roles in host defense [PDF]

, 2011
Activation of the inflammatory cysteine protease caspase-1 in inflammasome complexes plays a critical role in the host response to microbial infections.
Lieselotte eVande Walle, Lieselotte eVande Walle, Mohamed eLamkanfi, Mohamed eLamkanfi   +3 more
core   +2 more sources

Evolution of Antibiotic Resistance in Surrogates of Francisella tularensis (LVS and Francisella novicida): Effects on Biofilm Formation and Fitness

Frontiers in Microbiology, 2020
Francisella tularensis, the causative agent of tularemia, is capable of causing disease in a multitude of mammals and remains a formidable human pathogen due to a high morbidity, low infectious dose, lack of a FDA approved vaccine, and ease of ...
F. Biot, B. Bachert, K. Mlynek, R. Toothman, G. Koroleva, S. Lovett, C. Klimko, G. Palacios, C. Cote, J. Ladner, J. Bozue   +10 more
semanticscholar   +1 more source