Results 41 to 50 of about 27,961 (205)

Cathepsin B modulates lysosomal biogenesis and host defense against Francisella novicida infection [PDF]

, 2016
Lysosomal cathepsins regulate an exquisite range of biological functions, and their deregulation is associated with inflammatory, metabolic, and degenerative diseases in humans.
Gurung, Prajwal, Guy, Clifford S, Kanneganti, Thirumala-Devi, Karki, Rajendra, Lamkanfi, Mohamed, Lupfer, Christopher, Malireddi, RK Subbarao, Man, Si Ming, Neale, Geoffrey, Qi, Xiaopeng   +9 more
core   +1 more source

Francisella novicida pathogenicity island encoded proteins were secreted during infection of macrophage-like cells. [PDF]

PLoS ONE, 2014
Intracellular pathogens and other organisms have evolved mechanisms to exploit host cells for their life cycles. Virulence genes of some intracellular bacteria responsible for these mechanisms are located in pathogenicity islands, such as secretion ...
Rebekah F Hare, Karsten Hueffer
doaj   +1 more source

Nlrp3 Increases the Host’s Susceptibility to Tularemia

Frontiers in Microbiology, 2021
Francisella tularensis (F. tularensis) is a Gram-negative, intracellular bacterium and the causative agent of a fatal human disease known as tularemia. The CDC has classified F.
Ragavan V. Suresh, Elizabeth W. Bradley, Matthew Higgs, Vincenzo C. Russo, Maha Alqahtani, Wiehua Huang, Chandra Shekhar Bakshi, Meenakshi Malik   +7 more
doaj   +1 more source

Genetic Sequence Matching Using D4M Big Data Approaches

, 2014
Recent technological advances in Next Generation Sequencing tools have led to increasing speeds of DNA sample collection, preparation, and sequencing. One instrument can produce over 600 Gb of genetic sequence data in a single run.
Dodson, Stephanie, Kepner, Jeremy, Ricke, Darrell O.   +2 more
core   +1 more source

Comparison of Francisella tularensis genomes reveals evolutionary events associated with the emergence of human pathogenic strains [PDF]

, 2007
BACKGROUND: Francisella tularensis subspecies tularensis and holarctica are pathogenic to humans, whereas the two other subspecies, novicida and mediasiatica, rarely cause disease. To uncover the factors that allow subspecies tularensis and holarctica to
Laurence Rohmer, Christine Fong, Simone Abmayr, Michael Wasnick, Theodore Larson Freeman, Matthew Radey, Tina Guina, Kerstin Svensson, Hillary S Hayden, Michael Jacobs, Larry A Gallagher, Colin Manoil, Robert K Ernst, Becky Drees, Danielle Buckley, Eric Haugen, Donald Bovee, Yang Zhou, Jean Chang, Ruth Levy, Regina Lim, Will Gillett, Don Guenthener, Allison Kang, Scott A Shaffer, Greg Taylor, Jinzhi Chen, Byron Gallis, David A D'Argenio, Mats Forsman, Maynard V Olson, David R Goodlett, Rajinder Kaul, Samuel I Miller, Mitchell J Brittnacher   +34 more
core   +1 more source

Tularemia treatment: experimental and clinical data

Frontiers in Microbiology
Tularemia is a zoonosis caused by the Gram negative, facultative intracellular bacterium Francisella tularensis. This disease has multiple clinical presentations according to the route of infection, the virulence of the infecting bacterial strain, and ...
Max Maurin, Max Maurin, Léa Pondérand, Léa Pondérand, Aurélie Hennebique, Aurélie Hennebique, Isabelle Pelloux, Sandrine Boisset, Sandrine Boisset, Yvan Caspar, Yvan Caspar   +10 more
doaj   +1 more source

Global transcriptional response to mammalian temperature provides new insight into pathogenesis [PDF]

, 2008
Background After infecting a mammalian host, the facultative intracellular bacterium, Francisella tularensis, encounters an elevated environmental temperature.
Joseph Horzempa, Paul E Carlson, Dawn M O'Dee, Robert MQ Shanks, Gerard J Nau, J Ellis, A Sjostedt, DT Dennis, BP Berdal, PC Oyston, FE Nano, I Golovliov, K Deng, J Lenco, JT Sullivan, PE Carlson Jr, A Qin, J Su, DS Weiss, S Twine, JA Carroll, JF Miller, C Ojaimi, LM Smoot, T Tobe, CJ Hueck, U Zuber, DB Straus, ME Konkel, M Ericsson, M Ericsson, KL Meibom, NB Bhatnagar, SA Shaffer, NP Mohapatra, S Patel, SF Altschul, L Falquet, MJ Blaser, Z Xiang, MK Townsend, EB Nix, OM de Bruin, CD Herren, C Siatskas, MG Tozzi, K Hammer-Jespersen, RW Titball, A Sjostedt, CM Lauriano, A Brotcke, DL Clemens, A Ben Nasr, GS Schulert, A Balagopal, RE Chamberlain, TR Golub, S Rozen, J Horzempa, RM Shanks, I Golovliov, J Horzempa, PH Edelstein, JG Smedley 3rd, CM Robinson, SD Tachado, XH Lai, TM Maier, G Ruvkun, ED LoVullo, R Tempel, CG Gray, TM Maier, JC Charity   +73 more
core   +2 more sources

The First Report of Cod Gill Poxvirus in Gills of Atlantic Cod (Gadus morhua L.) Suffering From Cardiorespiratory Disease

Journal of Fish Diseases, Volume 48, Issue 4, April 2025.
ABSTRACT Atlantic cod farming experiences renewed growth in Norway, and increased awareness is essential to address emerging diseases in this species. There are few reports on gill diseases in cod, and to date, no viral gill infections of cod have been documented. In this study, we collected samples from three sequential time points in summer 2023 from
Mona C. Gjessing, Torstein Tengs, Hanne Nilsen, Saima Mohammad, Simon C. Weli   +4 more
wiley   +1 more source

Non-vaccinal prophylaxis of tularemia

Frontiers in Microbiology
Tularemia is a re-emerging zoonosis in many endemic countries. It is caused by Francisella tularensis, a gram-negative bacterium and biological threat agent.
Max Maurin, Max Maurin, Aurélie Hennebique, Aurélie Hennebique, Camille Brunet, Léa Pondérand, Léa Pondérand, Isabelle Pelloux, Sandrine Boisset, Sandrine Boisset, Yvan Caspar, Yvan Caspar   +11 more
doaj   +1 more source

Presence of Francisella tularensis subsp. holarctica DNA in the Aquatic Environment in France

Microorganisms, 2021
In 2018, the incidence of tularemia increased twofold in the west of France, with many pneumonic forms, suggesting environmental sources of infection. We investigated the presence of Francisellatularensis subsp.
Camille D. Brunet, Aurélie Hennebique, Julien Peyroux, Isabelle Pelloux, Yvan Caspar, Max Maurin   +5 more
doaj   +1 more source