Results 81 to 90 of about 6,113 (163)

Gluconeogenesis, an essential metabolic pathway for pathogenic Francisella

, 2015
Intracellular multiplication and dissemination of the infectious bacterial pathogen Francisella tularensis implies the utilization of multiple host-derived nutrients. Here, we demonstrate that gluconeogenesis constitutes an essential metabolic pathway in
Ziveri, Jason, Barel, Monique, Alain Charbit, Brillet, Magali, Brissac, Terry, Marion Dupuis, Charbit, Alain, Lindsay Peyriga, Cahoreau, Edern, Kock, Stephanie, Elodie Ramond, Monique Barel, Dupuis, Marion, Ramond, Elodie, Tros, Fabiola, Stephanie Kock, Peyriga, Lindsay, Terry Brissac, Jason Ziveri, Fabiola Tros, Magali Brillet, Edern Cahoreau   +21 more
core   +1 more source

Protective potential of outer membrane vesicles derived from a virulent strain of Francisella tularensis

Frontiers in Microbiology
Francisella tularensis secretes tubular outer membrane vesicles (OMVs) that contain a number of immunoreactive proteins as well as virulence factors.
Ivona Pavkova, Jan Bavlovic, Klara Kubelkova, Jiri Stulik, Jana Klimentova   +4 more
doaj   +1 more source

Decoding the Black Box of Fish Vaccines Efficacy in Basic and Applied Contexts

Reviews in Aquaculture, Volume 18, Issue 4, September 2026.
ABSTRACT Vaccines are the frontline defense in aquaculture, yet predicting their real‐world performance remains a tricky puzzle. Unlike terrestrial veterinary vaccines, fish vaccines largely operate through “Black Box” processes, where we observe the outcomes but rarely understand the underlying immune mechanisms. Laboratory trials, though informative,
Jiří Kyslík, Mikolaj Adamek, Tomáš Korytář   +2 more
wiley   +1 more source

Identification of Francisella tularensis cluster in central and western Europe [PDF]

, 2009
We conducted a molecular analysis of Francisella tularensis strains isolated in Switzerland and identified a specific subpopulation belonging to a cluster of F. tularensis subsp.
Joachim Frey, Johansson, Anders,, Frey, Joachim, Anders Johansson, Johansson A., A., Pilo, Paola, Frey J., J., Paola Pilo   +7 more
core   +2 more sources

Putting the Jigsaw Together - A Brief Insight Into the Tularemia

Open Life Sciences, 2015
Tularemia is a debilitating febrile and potentially fatal zoonotic disease of humans and other vertebrates caused by the Gram-negative bacterium Francisella tularensis. The natural reservoirs are small rodents, hares, and possibly amoebas in water.
Kubelkova K., Macela A.
doaj   +1 more source

Underexplored Ligand‐Binding Features of FabI From Staphylococcus aureus and Escherichia coli: A Comparative Pharmacophoric Modeling and Surface Mapping Approach

ChemMedChem, Volume 21, Issue 15, 14 August 2026.
Antimicrobial resistance highlights the urgent need for novel FabI inhibitors. Using an integrated computational approach combining ConPhar pharmacophore modeling, FTMap surface mapping, and PLIP interaction profiling across experimental structures and structures from MD simulations, we identified a conserved binding core (Y156/Y157, A95) and ...
Pedro Tenório T. F. Leite, Lucas H. S. Ocarino, Gabriel C. Veríssimo, Philipe O. Fernandes, Dara Fernanda Pereira, Fernanda Kelly M. e Oliveira, Alberto Marbán‐González, José L. Medina‐Franco, Mateus Sá M. Serafim, Thales Kronenberger, Vinícius G. Maltarollo   +10 more
wiley   +1 more source

Streptavidins Coordinate Biotin Sequestration and Self‐Resistance Within a Biotin‐Pathway Antibiotic Network

Advanced Science, Volume 13, Issue 46, 17 August 2026.
A conserved genomic region between two streptavidin genes in Streptomyces packages biosynthetic gene clusters for diverse biotin‐pathway antibiotics: acidomycin, stravidin, the new non‐proteinogenic amino acid ANDA, and the new BioA inhibitor α‐methyl‐KAPA.
Sumire Kurosawa, Jingjun Mo, Xiaotong Diao, Feng Xie, Tingting Wang, Haowen Zhao, Dalei Wu, Rolf Müller, Chengzhang Fu   +8 more
wiley   +1 more source

Francisella-like endosymbiont in Dermacentor reticulatus collected in Portugal [PDF]

, 2011
In Portugal, recent studies have confirmed the presence of Francisella tularensis in Dermacentor reticulatus. Bacterial endosymbionts with significant homology to F. tularensis have been described in several species of ticks.
Teresa Soares, Líbia Zé-Zé, Maria Sofia Núncio, Núncio, Maria Sofia, Isabel Lopes de Carvalho, Zé-Zé, Líbia, Santos, Nuno, Lopes de Carvalho, Isabel, Soares, Teresa, Nuno Santos   +9 more
core   +1 more source

Francisella tularensis: vaccine development

, 2016
Bakalářská práce je zaměřena na bakterii Francisella tularensis, která je původcem infekčního onemocnění - tularémie. Práce se zabývá mikrobiologickou charakteristikou bakterie, včetně patogeneze a jsou popsány jednotlivé formy onemocnění.
Štěpánková, Barbora
core   +1 more source

Francisella IglG protein and the DUF4280 proteins: PAAR-like proteins in non-canonical Type VI secretion systems?

, 2016
Type VI secretion systems (T6SS) are bacterial molecular machines translocating effector proteins into target cells. T6SS are widely present in Gram-negative bacteria where they predominantly act to kill neighboring bacteria.
Thomas Henry, Claire Lays
core   +1 more source