Results 81 to 90 of about 17,776 (214)

Galectin‐9high Neutrophils Exacerbate Radiation‐Induced Frailty

Aging Cell, Volume 25, Issue 4, April 2026.
EccDNA shedding after skin radiation injury activates the JAK1/2‐STAT1 pathway in splenic GMP cells to induce the production of GAL‐9high neutrophils. This unique population of hyperactive GAL‐9high neutrophils is identified with characteristics of elevated NETs and IFN‐γ, etc.
Zhuo Cheng, Le Ma, Yan Chen, Jialun Li, Yali Dai, Wentao Xie, Yingjie Li, Tianlang Xu, Zhihe Hu, Weilin Huang, Jingyuan Zhou, Jie Wu, Long Chen, Chunmeng Shi   +13 more
wiley   +1 more source

Gluconeogenesis, an essential metabolic pathway for pathogenic Francisella

, 2015
Intracellular multiplication and dissemination of the infectious bacterial pathogen Francisella tularensis implies the utilization of multiple host-derived nutrients. Here, we demonstrate that gluconeogenesis constitutes an essential metabolic pathway in
Ziveri, Jason, Barel, Monique, Alain Charbit, Brillet, Magali, Brissac, Terry, Marion Dupuis, Charbit, Alain, Lindsay Peyriga, Cahoreau, Edern, Kock, Stephanie, Elodie Ramond, Monique Barel, Dupuis, Marion, Ramond, Elodie, Tros, Fabiola, Stephanie Kock, Peyriga, Lindsay, Terry Brissac, Jason Ziveri, Fabiola Tros, Magali Brillet, Edern Cahoreau   +21 more
core   +1 more source

Protective potential of outer membrane vesicles derived from a virulent strain of Francisella tularensis

Frontiers in Microbiology
Francisella tularensis secretes tubular outer membrane vesicles (OMVs) that contain a number of immunoreactive proteins as well as virulence factors.
Ivona Pavkova, Jan Bavlovic, Klara Kubelkova, Jiri Stulik, Jana Klimentova   +4 more
doaj   +1 more source

Balanced Expression of the Diiron Oxygenase BioE Is Essential for Biotin Homeostasis in Elizabethkingia meningoseptica

Advanced Science, Volume 13, Issue 10, 18 February 2026.
BioE is a new diiron oxygenase that catalyzes the conversion of long‐chain acyl groups into pimeloyl thioester, initiating biotin synthesis. The overexpression of EmBioE disrupts lipid metabolic homeostasis, requiring repressor BioL to maintain a balance between long‐chain fatty acids and biotin synthesis.
Meng Zhang, Ying‐ying Fu, Xiaoqiang Yang, Qiuying Qin, Xinyu Su, Jiaming Fang, Yanhua Kang, Qingwen He, Zhi Ruan, Yongchang Xu   +9 more
wiley   +1 more source

Francisella IglG protein and the DUF4280 proteins: PAAR-like proteins in non-canonical Type VI secretion systems?

, 2016
Type VI secretion systems (T6SS) are bacterial molecular machines translocating effector proteins into target cells. T6SS are widely present in Gram-negative bacteria where they predominantly act to kill neighboring bacteria.
Thomas Henry, Claire Lays
core   +1 more source

A short peptide derived from late embryogenesis abundant proteins enhances acid tolerance in Escherichia coli via modulation of two‐component regulatory systems

The FEBS Journal, Volume 293, Issue 3, Page 781-805, February 2026.
Expression of the LEA‐K peptide in E. coli BL21 (DE3) improved bacterial viability under acidic stress (pH4), suggesting a protective function. RNA‐sequencing of LEA‐K‐expressing vs. non‐expressing cells revealed 283 differentially expressed genes (DEGs). In silico docking linked LEA‐K to two‐component systems (TCS) proteins (Rcs, BtsS/R, and EnvZ/OmpR)
Khaled Metwally, Shinya Ikeno
wiley   +1 more source

Molecular Screening of Black Flies (Diptera: Simuliidae) for Vector‐Borne Zoonotic Pathogens, South Moravia, Czech Republic

Zoonoses and Public Health, Volume 73, Issue 1, Page 95-106, February 2026.
ABSTRACT Introduction Black flies (Simuliidae) are globally distributed blood‐feeding arthropods and vectors of viral, bacterial, and parasitic pathogens to many animal species, including humans. We investigated the occurrence of selected vector‐borne pathogens in black flies in South Moravia, Czech Republic, and evaluated their possible role in the ...
Silvie Šikutová, Kristína Mravcová, Jan Mendel, Oldřich Šebesta, Bohumil Sak, Nikola Holubová, Martin Kváč, Clifton McKee, Peter H. Adler, D. Otranto, Ivo Rudolf   +10 more
wiley   +1 more source

Putting the Jigsaw Together - A Brief Insight Into the Tularemia

Open Life Sciences, 2015
Tularemia is a debilitating febrile and potentially fatal zoonotic disease of humans and other vertebrates caused by the Gram-negative bacterium Francisella tularensis. The natural reservoirs are small rodents, hares, and possibly amoebas in water.
Kubelkova K., Macela A.
doaj   +1 more source

Francisella recognition by inflammasomes: differences between Mice and Men

Frontiers in Cellular and Infection Microbiology, 2011
Pathogen recognition by intracellular sensors involves the assembly of a caspase-1 activation machine termed the inflammasome. Intracellular pathogens like Francisella that gain access to the cytosolic detection systems are useful tools to uncover the ...
Mikhail A Gavrilin, Mark D Wewers
doaj   +1 more source

INTRAVACUOLAR LIFE CYCLE OF FRANCISELLA NOVICIDA IN DICTYOSTELIUM DISCOIDEUM

, 2019
Cilj istraživanja: Francisella novicida je unutarstanična bakterija koja može inficirati brojne stanice uključujući i stanice ameba. Pretpostavlja se da amebe imaju važnu ulogu za održavanje francizela u vodenom okolišu.
Marečić, Valentina
core