Results 31 to 40 of about 16,794 (216)

The immune response to <i>Francisella tularensis</i>. [PDF]

Front Microbiol
Francisella tularensis (Ft) is a Gram negative intracellular bacterial pathogen, commonly transmitted via arthropod bites, but is most lethal when contracted via inhalation. The nature of a Gram-negative intracellular pathogen presents unique challenges to the mammalian immune response, unlike more common viral pathogens and extracellular bacterial ...
Barthels DA, House RV, Gelhaus HC.
europepmc   +4 more sources

An Unusual Case of Francisella tularensis

Case Reports in Infectious Diseases, 2022
A 67-year-old male presented with complaints of weakness, fatigue, and shortness of breath in the context of a recent hospitalization for the same unresolved symptoms. After a largely nonspecific clinical presentation, a chest X-ray revealed a loculated pleural effusion.
Samantha Huang, Bradley Kaptur, Julius Manu, Elias Woldegabriel   +3 more
openaire   +3 more sources

Alternative activation of macrophages and induction of arginase are not components of pathogenesis mediated by Francisella species.

PLoS ONE, 2013
Virulent Francisella tularensis ssp tularensis is an intracellular, Gram negative bacterium that causes acute lethal disease following inhalation of fewer than 15 organisms.
Amanda J Griffin, Deborah D Crane, Tara D Wehrly, Dana P Scott, Catharine M Bosio   +4 more
doaj   +1 more source

Glycosylation of DsbA in Francisella tularensis subsp. tularensis [PDF]

Journal of Bacteriology, 2011
ABSTRACTInFrancisella tularensissubsp.tularensis, DsbA has been shown to be an essential virulence factor and has been observed to migrate to multiple protein spots on two-dimensional electrophoresis gels. In this work, we show that the protein is modified with a 1,156-Da glycan moiety inO-linkage.
Thomas, Rebecca M., Twine, Susan M., Fulton, Kelly M., Tessier, Luc, Kilmury, Sara L. N., Ding, Wen, Harmer, Nicholas, Michell, Stephen L., Oyston, Petra C. F., Titball, Richard W., Prior, Joann L.   +10 more
openaire   +3 more sources

Genomic characterization of Francisella tularensis and other diverse Francisella species from complex samples.

PLoS ONE, 2022
Francisella tularensis, the bacterium that causes the zoonosis tularemia, and its genetic near neighbor species, can be difficult or impossible to cultivate from complex samples.
David M Wagner, Dawn N Birdsell, Ryelan F McDonough, Roxanne Nottingham, Karisma Kocos, Kimberly Celona, Yasemin Özsürekci, Caroline Öhrman, Linda Karlsson, Kerstin Myrtennäs, Andreas Sjödin, Anders Johansson, Paul S Keim, Mats Forsman, Jason W Sahl   +14 more
doaj   +2 more sources

Tularemia treatment: experimental and clinical data

Frontiers in Microbiology
Tularemia is a zoonosis caused by the Gram negative, facultative intracellular bacterium Francisella tularensis. This disease has multiple clinical presentations according to the route of infection, the virulence of the infecting bacterial strain, and ...
Max Maurin, Max Maurin, Léa Pondérand, Léa Pondérand, Aurélie Hennebique, Aurélie Hennebique, Isabelle Pelloux, Sandrine Boisset, Sandrine Boisset, Yvan Caspar, Yvan Caspar   +10 more
doaj   +1 more source

Non-vaccinal prophylaxis of tularemia

Frontiers in Microbiology
Tularemia is a re-emerging zoonosis in many endemic countries. It is caused by Francisella tularensis, a gram-negative bacterium and biological threat agent.
Max Maurin, Max Maurin, Aurélie Hennebique, Aurélie Hennebique, Camille Brunet, Léa Pondérand, Léa Pondérand, Isabelle Pelloux, Sandrine Boisset, Sandrine Boisset, Yvan Caspar, Yvan Caspar   +11 more
doaj   +1 more source

Revisiting Francisella tularensis subsp. holarctica, Causative Agent of Tularemia in Germany With Bioinformatics: New Insights in Genome Structure, DNA Methylation and Comparative Phylogenetic Analysis

Frontiers in Microbiology, 2018
Francisella (F.) tularensis is a highly virulent, Gram-negative bacterial pathogen and the causative agent of the zoonotic disease tularemia. Here, we generated, analyzed and characterized a high quality circular genome sequence of the F.
Anne Busch, Prasad Thomas, Eric Zuchantke, Holger Brendebach, Kerstin Neubert, Josephine Gruetzke, Sascha Al Dahouk, Martin Peters, Helmut Hotzel, Heinrich Neubauer, Herbert Tomaso   +10 more
doaj   +1 more source

Nutritional virulence of Francisella tularensis [PDF]

Frontiers in Cellular and Infection Microbiology, 2013
One of the mostfundamental aspects of infectious diseases is microbial acquisition of nutrients in vivo, which impacts virulence and antibiotic treatment.This article is focused on nutritional virulence of F.tularensis.
Šantić, Marina, Abu Kwaik, Yousef
openaire   +5 more sources

Rapid dissemination of Francisella tularensis and the effect of route of infection

BMC Microbiology, 2008
Background Francisella tularensis subsp. tularensis is classified as a Category A bioweapon that is capable of establishing a lethal infection in humans upon inhalation of very few organisms.
Jerabek Paul A, Morris Elizabeth G, Li Qun, Chang Tingtung A, Mares Chris A, Wang Zheng J, Ojeda Sandra S, Teale Judy M   +7 more
doaj   +1 more source