Association between perivascular diffusion and white matter microstructural integrity, free water, Aβ burden, and cognition: diffusion tensor vs. kurtosis tensor [PDF]
Frontiers in Aging NeuroscienceBackgroundPerivascular diffusion holds great potential for the non-invasive assessment of the glymphatic system (GS). However, Gaussian model-based diffusion tensor imaging analysis along the perivascular space (DTI-ALPS) is limited by microstructural ...
Zhiming Zeng +17 more
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Association of glymphatic dysfunction, free water, white matter integrity and long-term memory performance in aging autistic adults [PDF]
Molecular AutismBackground Autistic adults are at elevated risk of accelerated cognitive aging and Alzheimer’s disease and related dementias (ADRD), yet the underlying neurobiological mechanisms remain poorly understood. Dysfunction in the glymphatic system—a brain-wide
Yuanchao Zhang +10 more
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NeuroradiologyAbstract Purpose Diffusion MRI–based indirect indices of neurofluid dynamics, such as diffusion tensor imaging along the perivascular space (DTI-ALPS) and extracellular free water (FW), have been reported to have prognostic implications in glioblastoma.
Chul-Kee Park +2 more
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Association of MRI indexes of glymphatic system with brain atrophy and cognitive impairment in cerebral small vessel disease [PDF]
NeuroImage: ClinicalBackground and objective: The glymphatic system constitutes a brain-wide perivascular network responsible for brain metabolic waste removal, which may underlie pathogenesis in cerebral small vessel disease (CSVD).
Lulu Ai +6 more
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Association of choroid plexus volume, glymphatic system markers, and cognitive impairment in HIV-associated neurocognitive disorders [PDF]
BMC Infectious DiseasesBackground Although combined antiretroviral therapy (cART) effectively suppresses viral replication, HIV-associated neurocognitive disorders (HAND) remain prevalent.
Wenru Gong +7 more
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Free water in the external globus pallidus predicts mild cognitive impairment in Parkinson’s disease and is associated with serum neurofilament light chain levels [PDF]
npj Parkinson's DiseaseThis study explored free-water diffusion tensor imaging (FW-DTI) in the basal ganglia as a biomarker for mild cognitive impairment (MCI) in Parkinson’s disease (PD).
Huimin Chen +10 more
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Corrigendum to: Contralateral neurofluid dynamics predict survival in IDH wild-type glioblastoma: A DTI-ALPS and free water imaging study. [PDF]
Neuro Oncoleuropepmc +2 more sources
Comparison of two different analysis approaches for DTI free-water corrected and uncorrected maps in the study of white matter microstructural integrity in individuals with depression [PDF]
Human Brain Mapping, 2017 Maurizio Bergamino +2 more
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Free‐water DTI estimates from single b‐value data might seem plausible but must be interpreted with care [PDF]
Magnetic Resonance in Medicine, 2020 PurposeFree‐water elimination DTI (FWE‐DTI) has been used widely to distinguish increases of free‐water partial‐volume effects from tissue’s diffusion in healthy aging and degenerative diseases. Because the FWE‐DTI fitting is only well‐posed for multishell acquisitions, a regularized gradient descent (RGD) method was proposed to enable application to ...
Marc Golub +2 more
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Scientific Reports, 2021 Magnetic resonance imaging (MRI) based diffusion tensor imaging (DTI) can assess white matter (WM) integrity through several metrics, such as fractional anisotropy (FA), axial/radial diffusivities (AxD/RD), and mode of anisotropy (MA).
Maurizio Bergamino +2 more
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