Scientific ReportsGlioma, a predominant type of brain tumor, can be fatal. This necessitates an early diagnosis and effective treatment strategies. Current diagnosis is based on biopsy, prompting the need for non invasive neuroimaging alternatives.
Sreejith Vidyadharan +4 more
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Scientific Reports, 2021 Magnetic resonance imaging (MRI) based diffusion tensor imaging (DTI) can assess white matter (WM) integrity through several metrics, such as fractional anisotropy (FA), axial/radial diffusivities (AxD/RD), and mode of anisotropy (MA).
Maurizio Bergamino +2 more
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Free water elimination and mapping from diffusion tensor imaging (DTI) in chronic schizophrenia
, 2017 Diffusion tensor imaging (DTI) acquisitions allows the comparison of diffusion characteristics in vivo and gives a unique insight into tissue structure and pathology. However, a limitation of DTI post-processing is the as-sumption of a Gaussian distribution of diffusion in neu-ral architecture.
Colgan, Niall +5 more
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Association of glymphatic dysfunction, free water, white matter integrity and long-term memory performance in aging autistic adults [PDF]
Molecular AutismBackground Autistic adults are at elevated risk of accelerated cognitive aging and Alzheimer’s disease and related dementias (ADRD), yet the underlying neurobiological mechanisms remain poorly understood. Dysfunction in the glymphatic system—a brain-wide
Yuanchao Zhang +10 more
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Neuro-OncologyAbstract Background Glioblastoma (GBM) may disrupt glymphatic function and neurofluid dynamics locally and in distant brain regions. However, the prognostic relevance of such alterations remains unclear.
Hagiwara Akifumi +2 more
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Microstructural white matter alterations in preclinical Alzheimer's disease detected using free water elimination diffusion tensor imaging. [PDF]
PLoS ONE, 2017 Brain changes associated with Alzheimer's disease (AD) begin decades before disease diagnosis. While β-amyloid plaques and neurofibrillary tangles are defining features of AD, neuronal loss and synaptic pathology are closely related to the cognitive ...
Andrew R Hoy +10 more
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Characterizing Peritumoral Tissue Using Free Water Elimination in Clinical DTI
, 2018 Finding an accurate microstructural characterization of the peritumoral region is essential to distinguish between edema and infiltration, enabling the distinction between tumor types, and to improve tractography in this region. Characterization of healthy versus pathological tissue is a key concern when modeling tissue microstructure in the ...
Ould Ismail, Abdol Aziz +7 more
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Association of MRI indexes of glymphatic system with brain atrophy and cognitive impairment in cerebral small vessel disease [PDF]
NeuroImage: ClinicalBackground and objective: The glymphatic system constitutes a brain-wide perivascular network responsible for brain metabolic waste removal, which may underlie pathogenesis in cerebral small vessel disease (CSVD).
Lulu Ai +6 more
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Association of choroid plexus volume, glymphatic system markers, and cognitive impairment in HIV-associated neurocognitive disorders [PDF]
BMC Infectious DiseasesBackground Although combined antiretroviral therapy (cART) effectively suppresses viral replication, HIV-associated neurocognitive disorders (HAND) remain prevalent.
Wenru Gong +7 more
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Free water in the external globus pallidus predicts mild cognitive impairment in Parkinson’s disease and is associated with serum neurofilament light chain levels [PDF]
npj Parkinson's DiseaseThis study explored free-water diffusion tensor imaging (FW-DTI) in the basal ganglia as a biomarker for mild cognitive impairment (MCI) in Parkinson’s disease (PD).
Huimin Chen +10 more
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