Results 1 to 10 of about 8,572,069 (168)

Investigating white matter alterations in Parkinson’s disease using multi-shell free-water DTI and NODDI: insights into neurodegeneration and levodopa effects [PDF]

Frontiers in Neurology
IntroductionParkinson’s disease (PD) is a progressive neurodegenerative disorder characterized by motor and non-motor symptoms. Levodopa remains the primary treatment, temporarily restoring dopamine levels and improving motor symptoms. Advanced diffusion
Maurizio Bergamino, Shuyi Zhu, Shuyi Zhu, Holly A. Shill, Ashley M. Stokes   +4 more
doaj   +7 more sources

Mapping Alzheimer’s disease pathology using free water through integrated analysis of plasma biomarkers, microstructural DTI metrics, and macrostructural MRI measures

Scientific Reports
Alzheimer’s disease (AD) is characterized by amyloid-beta (Aβ) and tau pathologies that drive neuroinflammation and neurodegeneration. Free water (FW), a diffusion tensor imaging (DTI) metric reflecting extracellular fluid changes, has emerged as a ...
Bo-Hyun Kim, Daeun Shin, Sung Hoon Kang, Hyemin Jang, Jihwan Yun, YuHyun Park, Henrik Zetterberg, Kaj Blennow, Fernando Gonzalez-Ortiz, Nicholas J. Ashton, Sung Tae Kim, Hee Jin Kim, Duk L. Na, Jun Pyo Kim, Sang Won Seo   +14 more
doaj   +6 more sources

Fixel-Based Analysis and Free Water Corrected DTI Evaluation of HIV-Associated Neurocognitive Disorders [PDF]

Frontiers in Neurology, 2021
Background: White matter (WM) damage is a consistent finding in HIV-infected (HIV+) individuals. Previous studies have evaluated WM fiber tract-specific brain regions in HIV-associated neurocognitive disorders (HAND) using diffusion tensor imaging (DTI).
Alan Finkelstein, Abrar Faiyaz, Miriam T. Weber, Xing Qiu, Md Nasir Uddin, Jianhui Zhong, Jianhui Zhong, Jianhui Zhong, Giovanni Schifitto, Giovanni Schifitto, Giovanni Schifitto   +10 more
doaj   +6 more sources

DTI-based upper limit of voxel free water fraction [PDF]

Heliyon, 2018
Background: Free water (FW) in neuroimaging is non-flowing extracellular water in the cranium and brain tissue, and includes both cerebral spinal fluid (CSF) and fluid in intercellular space or edema.
Paul M. Macey, M. Albert Thomas, Luke A. Henderson   +2 more
doaj   +6 more sources

White matter abnormalities in amyotrophic lateral sclerosis: a free water imaging study [PDF]

Frontiers in Neuroscience
ObjectiveTo investigate white matter microstructural alterations in amyotrophic lateral sclerosis (ALS) using free-water-corrected diffusion tensor imaging (FW-DTI), compare its findings with those of conventional DTI, and examine the clinical ...
Zelin Liu, Haiqing Yang, Jiawei Cui, Zhengkun Guan, Duo Gao, Pingyong Feng, He Yang, Wenyi Li, Yuanhui Zhao, Qianhang Yang, Xuyang Zheng, Qi Liu, Zuojun Geng, Zuojun Geng   +13 more
doaj   +3 more sources

Tissue-specific diffusion abnormalities and localized free-water reductions in hypertension despite no detectable group difference in the DTI-ALPS index [PDF]

Frontiers in Medicine
BackgroundEssential hypertension (HTN) is an established risk factor for cerebral small vessel disease and cognitive decline. Although conventional diffusion tensor imaging (DTI) has identified white matter (WM) abnormalities in HTN, these metrics are ...
Taipeng Zeng, Taipeng Zeng, Xiaoyang Wang, Wenhui Xu, Zhifeng Huang, Hui Xiong, Kanlin Lin, Hao Huang, Jianfeng Chu, Shangwen Xu, Liyuan Fu   +10 more
doaj   +3 more sources

Applying a free-water correction to diffusion imaging data uncovers stress-related neural pathology in depression

NeuroImage: Clinical, 2016
Diffusion tensor imaging (DTI) holds promise for developing our understanding of white-matter pathology in major depressive disorder (MDD). Variable findings in DTI-based investigations of MDD, however, have thwarted development of this literature ...
Maurizio Bergamino, Ofer Pasternak, Madison Farmer, Martha E. Shenton, J. Paul Hamilton   +4 more
doaj   +4 more sources

Association of reduced DTI-ALPS index and increased free water with glymphatic system alterations in noise-induced hearing loss: a neuroimaging study

Scientific Reports
To investigate diffusion changes suggestive of possible glymphatic alterations in patients with noise-induced hearing loss (NIHL), and to evaluate their relationships with free water (FW) and clinical characteristics. DTI scans were acquired from 48 NIHL
Liping Wang, Wei Lian, Ranran Huang, Aijie Wang, Minghui Lv, Xinyao Zhao, Zengcai Zhang, Guowei Zhang   +7 more
doaj   +4 more sources

Glymphatic dysfunction, plasma neurofilament light, and cortical free water mediate cognitive decline in familial frontotemporal lobar degeneration [PDF]

The Journal of Prevention of Alzheimer's Disease
Background: Familial frontotemporal lobar degeneration (f-FTLD) is the second most common form of young-onset dementia, with diverse clinical presentations, neuropathological substrates and genetic backgrounds.
Meiling Qiu, Li Ding, Rui Bao, Juanyu Gong, Wencai Ding, Zhiding Shao, Yongsheng Han   +6 more
doaj   +2 more sources

Putative glymphatic dysfunction links extracellular fluid dysregulation to white matter degeneration and clinical impairment in amyotrophic lateral sclerosis [PDF]

BMC Medicine
Background Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterized by progressive motor neuron degeneration and prominent extra-motor involvement. Impaired clearance of neurotoxic proteins has led to increasing interest in
Xin Jin, Yan Fu, Ting Qiu, Jianyu Li, Huixiong Zhang, Yifan Chen, Kewei Chen, Yuanchao Zhang, Junling Wang, Xiaoping Yi, Lena Palaniyappan, B. Blair Braden   +11 more
doaj   +2 more sources