Results 1 to 10 of about 12,150 (200)

Investigating white matter alterations in Parkinson’s disease using multi-shell free-water DTI and NODDI: insights into neurodegeneration and levodopa effects [PDF]

Frontiers in Neurology
IntroductionParkinson’s disease (PD) is a progressive neurodegenerative disorder characterized by motor and non-motor symptoms. Levodopa remains the primary treatment, temporarily restoring dopamine levels and improving motor symptoms. Advanced diffusion
Maurizio Bergamino, Shuyi Zhu, Shuyi Zhu, Holly A. Shill, Ashley M. Stokes   +4 more
doaj   +5 more sources

Association of reduced DTI-ALPS index and increased free water with glymphatic system alterations in noise-induced hearing loss: a neuroimaging study [PDF]

Scientific Reports
To investigate diffusion changes suggestive of possible glymphatic alterations in patients with noise-induced hearing loss (NIHL), and to evaluate their relationships with free water (FW) and clinical characteristics. DTI scans were acquired from 48 NIHL
Liping Wang, Wei Lian, Ranran Huang, Aijie Wang, Minghui Lv, Xinyao Zhao, Zengcai Zhang, Guowei Zhang   +7 more
doaj   +5 more sources

Mapping Alzheimer’s disease pathology using free water through integrated analysis of plasma biomarkers, microstructural DTI metrics, and macrostructural MRI measures

Scientific Reports
Alzheimer’s disease (AD) is characterized by amyloid-beta (Aβ) and tau pathologies that drive neuroinflammation and neurodegeneration. Free water (FW), a diffusion tensor imaging (DTI) metric reflecting extracellular fluid changes, has emerged as a ...
Bo-Hyun Kim, Daeun Shin, Sung Hoon Kang, Hyemin Jang, Jihwan Yun, YuHyun Park, Henrik Zetterberg, Kaj Blennow, Fernando Gonzalez-Ortiz, Nicholas J. Ashton, Sung Tae Kim, Hee Jin Kim, Duk L. Na, Jun Pyo Kim, Sang Won Seo   +14 more
doaj   +6 more sources

DTI-based upper limit of voxel free water fraction [PDF]

Heliyon, 2018
Background: Free water (FW) in neuroimaging is non-flowing extracellular water in the cranium and brain tissue, and includes both cerebral spinal fluid (CSF) and fluid in intercellular space or edema.
Paul M. Macey, M. Albert Thomas, Luke A. Henderson   +2 more
doaj   +6 more sources

Fixel-Based Analysis and Free Water Corrected DTI Evaluation of HIV-Associated Neurocognitive Disorders [PDF]

Frontiers in Neurology, 2021
Background: White matter (WM) damage is a consistent finding in HIV-infected (HIV+) individuals. Previous studies have evaluated WM fiber tract-specific brain regions in HIV-associated neurocognitive disorders (HAND) using diffusion tensor imaging (DTI).
Alan Finkelstein, Abrar Faiyaz, Miriam T. Weber, Xing Qiu, Md Nasir Uddin, Jianhui Zhong, Jianhui Zhong, Jianhui Zhong, Giovanni Schifitto, Giovanni Schifitto, Giovanni Schifitto   +10 more
doaj   +6 more sources

Applying a free-water correction to diffusion imaging data uncovers stress-related neural pathology in depression

NeuroImage: Clinical, 2016
Diffusion tensor imaging (DTI) holds promise for developing our understanding of white-matter pathology in major depressive disorder (MDD). Variable findings in DTI-based investigations of MDD, however, have thwarted development of this literature ...
Maurizio Bergamino, Ofer Pasternak, Madison Farmer, Martha E. Shenton, J. Paul Hamilton   +4 more
doaj   +4 more sources

Multimodal diffusion MRI biomarkers of white matter alterations and clinical impairment in mTBI [PDF]

Frontiers in Neuroscience
IntroductionMild traumatic brain injury (mTBI), which includes concussion, often results in subtle white matter abnormalities that are not detectable with conventional neuroimaging.
Maurizio Bergamino, Lauren R. Ott, Molly M. McElvogue, Ruchira M. Jha, Cindy Moreno, Ashley M. Stokes   +5 more
doaj   +2 more sources

Amyloid-beta statuses prediction with free water MR imaging features in Alzheimer’s disease using machine learning models [PDF]

BMC Medical Imaging
Purpose This study aimed to identify the effectiveness of free water MRI (FW-MRI) features for predicting amyloid-beta (Aβ) statuses in Alzheimer’s disease (AD) by constructing diagnostic models using machine learning analysis.
Rongshen Zhou, Xuan Sun, Siyu Chen, Shilong Zhao, Cui Zhao, Junda Qu, Weiyi Zeng, Chunlin Li, Xu Zhang, Zihan Li, Yiqing Wang, Ting Zhang, Xian Xu, Jianjun Jia, Ying Liang   +14 more
doaj   +2 more sources

Glymphatic system dysfunction in temporal lobe epilepsy with hippocampal sclerosis: MRI-based evaluation of circulatory markers and disease progression [PDF]

Frontiers in Neuroscience
ObjectivesIn this study, several MRI-derived glymphatic markers were utilized to evaluate alterations in glymphatic system (GS) function in patients with temporal lobe epilepsy and hippocampal sclerosis (TLE-HS).Methodswe assessed 160 participants ...
Yingpeng Kuang, Dingwen Hu, Hui Chu, Rongyu Zhang, Ziyu Diao, Kun Wang, Xiaomei Yue, Yuna Chen, Shijun Qiu, Shijun Qiu, Jie An, Jie An   +11 more
doaj   +2 more sources

Association between perivascular diffusion and white matter microstructural integrity, free water, Aβ burden, and cognition: diffusion tensor vs. kurtosis tensor [PDF]

Frontiers in Aging Neuroscience
BackgroundPerivascular diffusion holds great potential for the non-invasive assessment of the glymphatic system (GS). However, Gaussian model-based diffusion tensor imaging analysis along the perivascular space (DTI-ALPS) is limited by microstructural ...
Zhiming Zeng, Zhiming Zeng, Xin Jia, Xin Jia, Shushu Han, Cuidie Zeng, Cuidie Zeng, Jing Bi, Jing Bi, Lingchen Liu, Lingchen Liu, Yueming Wu, Yueming Wu, Tengao Gao, Tengao Gao, Lei Liang, Fangxiao Cheng, Fangxiao Cheng   +17 more
doaj   +2 more sources