Results 21 to 30 of about 12,150 (200)

Free-water imaging of the cholinergic basal forebrain and pedunculopontine nucleus in Parkinson's disease [PDF]

open access: yes, 2022
BACKGROUND: Free-water imaging can predict and monitor dopamine system degeneration in people with Parkinson's disease. It can also enhance the sensitivity of traditional diffusion tensor imaging (DTI) metrics for indexing neurodegeneration.
Lord, Sue   +15 more
core   +2 more sources

Free‐water DTI estimates from single b‐value data might seem plausible but must be interpreted with care [PDF]

open access: yesMagnetic Resonance in Medicine, 2020
PurposeFree‐water elimination DTI (FWE‐DTI) has been used widely to distinguish increases of free‐water partial‐volume effects from tissue’s diffusion in healthy aging and degenerative diseases. Because the FWE‐DTI fitting is only well‐posed for multishell acquisitions, a regularized gradient descent (RGD) method was proposed to enable application to ...
Marc Golub   +2 more
openaire   +3 more sources

Free-water diffusion tensor imaging detects occult periependymal abnormality in the AQP4-IgG-seropositive neuromyelitis optica spectrum disorder

open access: yesScientific Reports, 2022
To compare free-water corrected diffusion tensor imaging (DTI) measures in the normal-appearing periependymal area between AQP4-IgG-seropositive NMOSD and multiple sclerosis (MS) to investigate occult pathophysiology.
Minchul Kim   +6 more
doaj   +1 more source

Multi-compartment diffusion magnetic resonance imaging models link tract-related characteristics with working memory performance in healthy older adults

open access: yesFrontiers in Aging Neuroscience, 2022
Multi-compartment diffusion MRI metrics [such as metrics from free water elimination diffusion tensor imaging (FWE-DTI) and neurite orientation dispersion and density imaging (NODDI)] may reflect more specific underlying white-matter tract ...
Christopher E. Bauer   +6 more
doaj   +1 more source

Diffusion magnetic resonance imaging-based surrogate marker in amyotrophic lateral sclerosis

open access: yesExploration of Neuroprotective Therapy, 2023
Amyotrophic lateral sclerosis (ALS) is the most prevalent type of motor neuron disease (MND) and is diagnosed with a delay from the first appearance of symptoms.
Yuya Saito
doaj   +1 more source

Distinct white matter microstructural abnormalities and extracellular water increases relate to cognitive impairment in Alzheimer’s disease with and without cerebrovascular disease

open access: yesAlzheimer’s Research & Therapy, 2017
Background Mixed vascular and neurodegenerative dementia, such as Alzheimer’s disease (AD) with concomitant cerebrovascular disease, has emerged as the leading cause of age-related cognitive impairment. The brain white matter (WM) microstructural changes
Fang Ji   +10 more
doaj   +1 more source

Multi-site genetic analysis of diffusion images and voxelwise heritability analysis : a pilot project of the ENIGMA–DTI working group [PDF]

open access: yes, 2013
The ENIGMA (Enhancing NeuroImaging Genetics through Meta-Analysis) Consortium was set up to analyze brain measures and genotypes from multiple sites across the world to improve the power to detect genetic variants that influence the brain.
Sprooten, Emma   +63 more
core   +1 more source

White matter and nigral alterations in multiple system atrophy-parkinsonian type

open access: yesnpj Parkinson's Disease, 2021
Multiple system atrophy (MSA) is classified into two main types: parkinsonian and cerebellar ataxia with oligodendrogliopathy. We examined microstructural alterations in the white matter and the substantia nigra pars compacta (SNc) of patients with MSA ...
Takashi Ogawa   +14 more
doaj   +1 more source

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