Results 41 to 50 of about 10,072 (149)

Human biomarker navigator

iMeta, EarlyView.
The Human Biomarker Navigator integrates the disease continuum, biomarker dynamics, cross‐organ biomarker networks, biomarker classification, and technology‐driven paradigms. It maps how biomarkers link multi‐system physiology and pathology across the nervous, respiratory, endocrine, circulatory, immune, digestive, urinary, reproductive, and ...
Meng‐Yao Li, Qian Zhang, Zijie Wang, Zeping Gui, Jing Liu, Jingda Li, Maojun Jiang, Zukang Chang, Qingqing Han, Bendong Yang, Tariq Saeed, Jun Li, Jinghan Jia, Chenghu Song, Tong Shao, Tianhuan Peng, Xueying Zhang, Pingping Guo, Jun Luo, Gangao Yang, Yuan Wan, Gokhan Zengin, Quan Yuan, Lingru Li, Xiaohui Fan, Yang Luo, Lvyun Zhu, Yanfei Zheng, Wenjun Mao, Wenlong Sun   +29 more
wiley   +1 more source

Microstructural white matter alterations in preclinical Alzheimer's disease detected using free water elimination diffusion tensor imaging.

PLoS ONE, 2017
Brain changes associated with Alzheimer's disease (AD) begin decades before disease diagnosis. While β-amyloid plaques and neurofibrillary tangles are defining features of AD, neuronal loss and synaptic pathology are closely related to the cognitive ...
Andrew R Hoy, Martina Ly, Cynthia M Carlsson, Ozioma C Okonkwo, Henrik Zetterberg, Kaj Blennow, Mark A Sager, Sanjay Asthana, Sterling C Johnson, Andrew L Alexander, Barbara B Bendlin   +10 more
doaj   +1 more source

Diffusion MRI of the Body: Beyond PGSE‐EPI

Journal of Magnetic Resonance Imaging, EarlyView.
ABSTRACT Diffusion magnetic resonance imaging (dMRI) is a widely used clinical imaging technique which is sensitive to changes in tissue microstructure including cellularity, perfusion, and tissue damage. DMRI has been used in whole‐body imaging as well as in targeted imaging of every major anatomical region.
Matthew T. Cherukara, Wenbo Sun, David Leitão, Shaihan Malik, Radhouene Neji, Joseph V. Hajnal, Andrada Ianus   +6 more
wiley   +1 more source

Glymphatic system impairment in Wilson’s disease: An overlooked mechanism for neurological dysfunction?

NeuroImage
Background: Mounting evidence highlights the critical role of the brain’s glymphatic system in cerebral waste clearance, yet its alterations in Wilson’s disease (WD) remain unclear.
Gaiying Li, Siyuan Fang, Yupeng Wu, Xiangzhen Yuan, Ying Tang, Xiaozhong Jing, Luguang Chen, Xiaoping Wang, Jianqi Li   +8 more
doaj   +1 more source

Hemispheric lateralization of white matter microstructure in children and its potential role in sensory processing dysfunction

Frontiers in Neuroscience, 2023
Diffusion tensor imaging (DTI) studies have demonstrated white matter microstructural differences between the left and right hemispheres of the brain. However, the basis of these hemispheric asymmetries is not yet understood in terms of the biophysical ...
Shalin A. Parekh, Jamie Wren-Jarvis, Maia Lazerwitz, Maia Lazerwitz, Mikaela A. Rowe, Rachel Powers, Rachel Powers, Ioanna Bourla, Lanya T. Cai, Robyn Chu, Kaitlyn Trimarchi, Rafael Garcia, Elysa J. Marco, Pratik Mukherjee   +13 more
doaj   +1 more source

Transcranial Pulse Stimulation Enhances Dexterity in Parkinson's Disease: A Randomized Sham‐Controlled Trial

Movement Disorders, EarlyView.
Abstract Background Ultrasound‐based neuromodulation, capable of reaching deep brain areas with high precision, represents cutting‐edge technology in non‐invasive brain stimulation and is investigated as a novel treatment for neurological and psychiatric disorders, including Parkinson's disease (PD).
Eva Matt, Nina Plischek, Michael Mitterwallner, Sonja Radjenovic, Alexandra Weber, Alina Domitner, Gregor Dörl, Anna Zettl, Sarah Osou, Anna Leitgeb, Agnes Santer, Viktoria Winkler, Julia Mandelburger, Heidemarie Zach, Roland Beisteiner   +14 more
wiley   +1 more source

Regularized Joint Reconstruction and Slab Combination for Accelerated Three‐Dimensional Multi‐Slab Diffusion‐Weighted Imaging Using Multi‐Scale Energy Models

Magnetic Resonance in Medicine, EarlyView.
ABSTRACT Purpose To jointly reconstruct high‐resolution diffusion‐weighted volumes and eliminate slab‐boundary artifacts while preserving fine anatomical detail from undersampled 3D multi‐slab k‐space acquisitions. Methods A bilinear forward model was formulated to describe the 3D multi‐slab acquisition, treating the image volume and slab excitation ...
Reza Ghorbani, Jyothi Rikhab Chand, Chu‐Yu Lee, Mathews Jacob, Merry Mani   +4 more
wiley   +1 more source

Comparative Performance Analysis of an Open Source Motion‐Compensated Cardiac Diffusion Sequence Across Different MRI Systems and Gradient Strengths—A Pilot Study

Magnetic Resonance in Medicine, EarlyView.
ABSTRACT Purpose To validate the performance of an open‐source cardiac diffusion sequence framework and to investigate hardware‐based performance differences. Methods Three second order motion compensated sequence files were compiled using Pulseq and applied across different MRI systems to image five volunteers.
Eric Arbes, Ariel Hannum, Johannes Fischer, Qingping Chen, Sebastian Littin, Alexander Maier, Michael Bock, Simon Reiss   +7 more
wiley   +1 more source

Artificial intelligence empowers targeted protein degradation: Core technological innovations, multi‐scenario applications, and translational prospects

Smart Molecules, EarlyView.
AI is transforming TPD by improving the design, prediction, and optimization of degraders such as PROTACs, molecular glues, and LYTACs. This review summarizes key AI‐driven advances, highlights applications across drug discovery stages, and discusses remaining challenges and future directions for accelerating the development of therapies against ...
Shuanglin Qin, Rui Peng, Guangshuai Zhang, Si Yan, Jin Xiao, Zishu Liu, Ziyu Tan, Qingqing Xie, Shangjie Li, Wei Luo, Xiaohe Xiao   +10 more
wiley   +1 more source

Putative glymphatic dysfunction links extracellular fluid dysregulation to white matter degeneration and clinical impairment in amyotrophic lateral sclerosis

BMC Medicine
Background Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterized by progressive motor neuron degeneration and prominent extra-motor involvement. Impaired clearance of neurotoxic proteins has led to increasing interest in
Xin Jin, Yan Fu, Ting Qiu, Jianyu Li, Huixiong Zhang, Yifan Chen, Kewei Chen, Yuanchao Zhang, Junling Wang, Xiaoping Yi, Lena Palaniyappan, B. Blair Braden   +11 more
doaj   +1 more source