Results 61 to 70 of about 10,072 (149)

Evaluation of Third‐Order Motion‐Compensated Cardiac Diffusion Tensor Imaging Across Cardiac Phases Using an Ultra‐High‐Performance Clinical Scanner

Magnetic Resonance in Medicine, Volume 96, Issue 3, Page 1365-1378, September 2026.
ABSTRACT Purpose To evaluate a third‐order motion‐compensated spin echo (M3‐MCSE) sequence at multiple cardiac phases on a clinical 3 T MRI scanner with ultra‐high performance (UHP) gradients (200 mT/m), compared with stimulated echo acquisition mode (STEAM) and second‐order MCSE (M2‐MCSE) for cardiac diffusion tensor imaging (cDTI).
Ke Wen, Pedro F. Ferreira, Alberto Di Biase Oemick, Ricardo Wage, Karl P. Kunze, Fanwen Wang, Dudley J. Pennell, Andrew D. Scott, Sonia Nielles‐Vallespin   +8 more
wiley   +1 more source

Decreased diffusivity along the perivascular spaces in bipolar disorder: an MRI-based cross-sectional and Mendelian randomization study

Translational Psychiatry
The pathophysiology of bipolar disorder (BD) remains unclear. We investigated whether diffusion tensor imaging along perivascular spaces (DTI-ALPS), a putative MRI marker of glymphatic function, is altered in BD and whether this index relates to ...
Zhuohui Chen, Ziwei Teng, Yan Qiu, Sujuan Li, Xuelei Xu, Min Yang, Jindong Chen, Dong Yang, Hao Li   +8 more
doaj   +1 more source

Evaluating the Influence of Injury‐Induced Microstructural Variations on the Efficacy of a Diffusion MRI‐Derived Axon Diameter Surrogate

Magnetic Resonance in Medicine, Volume 96, Issue 3, Page 1355-1364, September 2026.
ABSTRACT Purpose To investigate the utility of a recently demonstrated diffusion MRI derived axon diameter surrogate measure (∆D⟂) under pathologic conditions induced by a spinal cord injury model. Methods Contusion injuries were performed on the thoracic–lumbar spinal cord of adult male rats.
Hannah E. Alderson, Chaoqi Mu, Li Min Chen, Mark D. Does, Kevin D. Harkins   +4 more
wiley   +1 more source

Sensitivity of restriction spectrum imaging to memory and neuropathology in Alzheimer’s disease

Alzheimer’s Research & Therapy, 2017
Background Diffusion imaging has demonstrated sensitivity to structural brain changes in Alzheimer’s disease (AD). However, there remains a need for a more complete characterization of microstructural alterations occurring at the earliest disease stages,
Emilie T. Reas, Donald J. Hagler, Nathan S. White, Joshua M. Kuperman, Hauke Bartsch, Karalani Cross, Richard Q. Loi, Akshara R. Balachandra, M. J. Meloy, Christina E. Wierenga, Douglas Galasko, James B. Brewer, Anders M. Dale, Linda K. McEvoy   +13 more
doaj   +1 more source

Four Directions, One Solution: Enabling Rapid Diffusion Tensor MRI for Ultra‐Low Field Using Deep Learning

Magnetic Resonance in Medicine, Volume 96, Issue 3, Page 1413-1426, September 2026.
ABSTRACT Purpose This study revisits the tetrahedral encoding strategy originally proposed to accelerate Diffusion Tensor Magnetic Resonance Imaging (DT‐MRI) by reducing the requisite number of diffusion‐weighted measurements to four. We examine its practical limitations and explore how artificial intelligence (AI) can extend its utility. Specifically,
Joshua Mawuli Ametepe, James Gholam, Leandro Beltrachini, Mara Cercignani, Derek Kenton Jones   +4 more
wiley   +1 more source

Macrostructural and microstructural alterations of hippocampal subregions in T2DM: NODDI provides added value to DTI and volumetric analyses

Brain Research Bulletin
Objective: We explored macrostructural and microstructural changes in the hippocampal subregions of patients with type 2 diabetes mellitus (T2DM) and compared the effectiveness of neurite orientation dispersion and density imaging (NODDI) with that of ...
Xuan Huang, Ziyu Diao, Die Shen, Jianyu Li, Jiahe Wang, Kun Wang, Shijun Qiu   +6 more
doaj   +1 more source

Targeting progressive multiple sclerosis: Toward mechanism‐informed precision medicine

Journal of Internal Medicine, Volume 300, Issue 3, Page 238-257, September 2026.
Abstract Multiple sclerosis has undergone a therapeutic revolution over the past three decades. Randomized clinical trials and real‐world data demonstrate that modern disease‐modifying therapies substantially reduce relapse rates and acute inflammatory activity detected by magnetic resonance imaging (MRI).
Fredrik Piehl, Gonçalo Castelo‐Branco, Maja Jagodic, Tomas Olsson   +3 more
wiley   +1 more source

Sex Differences in Alzheimer's Disease Revealed by Free-Water Diffusion Tensor Imaging and Voxel-Based Morphometry. [PDF]

J Alzheimers Dis, 2022
Bergamino M, Keeling EG, Baxter LC, Sisco NJ, Walsh RR, Stokes AM.   +5 more
europepmc   +1 more source

Normal‐Appearing White Matter Injury Mediates Chronic Deep Venous Hypoxia and Disease Progression in Multiple Sclerosis

Annals of Clinical and Translational Neurology, Volume 13, Issue 8, Page 1686-1696, August 2026.
ABSTRACT Objective To explore how cerebral hypoxia and Normal‐Appearing White Matter (NAWM) integrity affect MS lesion burden and clinical course. Methods Seventy‐nine MS patients, including 13 clinically isolated syndrome (CIS) patients and 66 relapsing–remitting multiple sclerosis (RRMS) patients, and 44 healthy controls (HCs) were recruited from ...
Xinli Wang, Huiying Wang, Zhizheng Zhuo, Ai Guo, Ke Lv, Decai Tian, Chao Chai, Yunyun Duan, Shuang Xia   +8 more
wiley   +1 more source

Early identification of vascular cognitive impairment from a multimodal perspective: a combined diagnosis from targeted cognitive assessments, imaging biomarkers, and molecular fluid biomarkers to ecological behavioral characteristics

Alzheimer's &Dementia, Volume 22, Issue 8, August 2026.
Abstract Vascular cognitive impairment (VCI), the second leading cause of dementia, is characterized by heterogeneous pathophysiology and a potentially reversible early phase, underscoring the need for timely identification. This review synthesizes advances across four complementary domains – targeted cognitive assessments, imaging biomarkers ...
Wenqi Song, Xiaoqun Liu, Tianrui Yu, Yuanyuan Xiang, Peijie Fu, Moxin Wu, Xiaoping Yin, Xiaorong Zhang, Zhiying Chen   +8 more
wiley   +1 more source