Results 71 to 80 of about 10,072 (149)

Accurate low and high grade glioma classification using free water eliminated diffusion tensor metrics and ensemble machine learning

Scientific Reports
Glioma, a predominant type of brain tumor, can be fatal. This necessitates an early diagnosis and effective treatment strategies. Current diagnosis is based on biopsy, prompting the need for non invasive neuroimaging alternatives.
Sreejith Vidyadharan, B. V. V. S. N. Prabhakar Rao, P. Yogeeswari, C. Kesavadas, Venkateswaran Rajagopalan   +4 more
doaj   +1 more source

Characterizing Peritumoral Tissue Using Free Water Elimination in Clinical DTI

, 2018
Finding an accurate microstructural characterization of the peritumoral region is essential to distinguish between edema and infiltration, enabling the distinction between tumor types, and to improve tractography in this region. Characterization of healthy versus pathological tissue is a key concern when modeling tissue microstructure in the ...
Ould Ismail, Abdol Aziz, Parker, Drew, Hernandez-Fernandez, Moises, Brem, Steven, Alexander, Simon, Pasternak, Ofer, Caruyer, Emmanuel, Verma, Ragini   +7 more
openaire   +1 more source

The role of vascular risk factors in white matter tract microstructure: a multi‐cohort study in older adults

Alzheimer's &Dementia, Volume 22, Issue 8, August 2026.
Abstract INTRODUCTION Vascular risk factors (VRFs) contribute to white matter microstructural degeneration, but their tract‐specific contributions are unclear. We assessed the independent associations of four major VRFs with white matter microstructure in a large, multi‐cohort study.
James D. LeFevre, Yukti Vyas, Aditi Sathe, Niranjana Shashikumar, Kimberly R. Pechman, Yisu Yang, Alaina Durant, Praitayini Kanakaraj, Michael E. Kim, Chenyu Gao, Nancy R. Newlin, Karthik Ramadass, Nazirah Mohd Khairi, Zhiyuan Li, Tianyuan Yao, Shannon L. Risacher, Panpan Zhang, Kurt G. Schilling, Annie J. Lee, Adam M. Brickman, Richard Mayeux, Jesse Mez, for the Alzheimer's Disease Neuroimaging Initiative (ADNI), The Alzheimer's Disease Sequencing Project (ADSP)The ADSP Phenotype Harmonization Consortium (ADSP‐PHC), Walter Kukull, Sarah A. Biber, Bennett A. Landman, Barbara B. Bendlin, Sterling C. Johnson, Julie Schneider, Lisa L. Barnes, David A. Bennett, Andrew J. Saykin, Michael L. Cuccaro, Timothy J. Hohman, Angela L. Jefferson, Derek B. Archer   +36 more
wiley   +1 more source

Diffusion MRI and α‐Synuclein Seed Amplification Status in Parkinson's Disease

Annals of Neurology, Volume 100, Issue 2, Page 295-304, August 2026.
Objective Positive α‐synuclein seed amplification assay (SAA) is a biomarker found in most people with Parkinson's disease (PD). We explored if free‐water (FW) imaging detects microstructural differences in the brains of patients with early PD with SAA+ or SAA– status.
Shannon Y. Chiu, Wei‐en Wang, Robin Chen, Jesse C. DeSimone, Derek B. Archer, Charles H. Adler, Shyamal H. Mehta, Sara R. Dresler, Melissa J. Armstrong, Nikolaus McFarland, Michael Okun, David E. Vaillancourt, Parkinson's Progression Markers Initiative, Neha Prakash, Tanya Simuni, Nabila Dahodwala, Caroline Tanner, Lana Chahine, Brit Mollenhauer, Anat Mirelman, Roy Alcalay; Katherine Leaver, Marie Saint‐Hilaire, Ruth Schneider, Christopher Tarolli, Werner Poewe, Aleksandar Videnovic, David Standaert, Marissa Dean, Sonja Jonsdottir, Rejko Krueger, Claire Pauly, Stewart Factor, Penelope Hogarth, Robert Hauser, Amy Amara, Michelle Fullard, Cyrus Zabetian, Hubert Fernandez, Kathrin Brockmann, Isabel Wurster, Yen Tai, Paolo Barone, Marina Picillo, Stuart Isaacson, Alberto Espay, Eduardo Tolosa, Javier Ruiz Martinez, Leonidas Stefanis, Kelvin Chou, Lorraine Kalia, Connie Marras, David Grimes, Tiago Mestre, Rajesh Pahwa, Mark Lew, Holly Shill, Shyamal Mehta, Giulietta Riboldi, Nikolaus McFarland, Ron Postuma, Zoltan Mari, David Ledingham, Nicola Pavese, Michele Hu, Norbert Brueggemann, Christine Klein, Bastiaan Bloem, Cristina Simonet, Alastair Noyce, Anette Janzen, David Pedrosa, Wolfgang Oertel, Njideka Okubadejo, David Shprecher, Arjun Tarakad, Emile Moukheiber, Joy Antala, Carla Aranda, Karen Williams, Sophia Melton, Karina Benson, Ashwini Ramachandran, Danielle Potts, Grace LaMoure, Ritikha Vengadesh, Ryan Manzler, Jaime Heller, Primi Ranola, Farah Kausar, Sherri Mosovsky, Diana Willeke, Elizabeth Kalinkara Gomez, Janelle Rodriguez, Nobuko Kemmotsu, May Eshel, Deborah Raymond, Abigail Desrosiers, Raymond James, Lauren Jackson, Iris Egner, Wesley Schlett, Courtney Blair, Lauren Ruffrage, Berenice Sevilla, Barbara Sommerfeld, Dustin Le, Erica Botting, Gabriella Mazur, Daniele Derlein, Ying Liu, Ciera Cobb, Olivia Masiewicz, Jennifer Mule, Michael Morsillo, Ella Hilt, Lisbeth Pennente, Bobbie Stubbeman, Alicia Garrido, Valeria Ravasi, Ioana Croitoru, Christos Koros, Nikolas Papagiannakis, Frank Ferrari, Mengyu Zheng, Shawna Reddie, Alicia Alejandra, Andrea Gray, Alejandra Valenzuela, Caitlin Goodman, Sara Dresler, Neil Santos, Fahrial Esha, Kyle Rizer, Nadine Zablith, Liliana Dumitrescu, Debra Galley, Victoria Kate Foster, Jamil Razzaque, Madita Grümmer, Yara Krasowski, Elisabeth Sittig, Oluwadamilola Ojo, Kelly Clark, Rory Mahabir, Kori Ribb, Shamera Willoughby   +145 more
wiley   +1 more source

Gray matter microstructure alterations with excess extra-cellular free water contribute to cognitive dysfunction in bipolar disorder: A comparative analysis with white matter pathology

NeuroImage
Background: Bipolar disorder (BD) is a chronic mental disorder involving cognitive dysfunction. Imaging studies reveal reduced cortical thickness and impaired white matter integrity in BD; however, the biological pathophysiology underlying cognitive ...
Yasuhito Nagai, Toshimasa Fujimura, Wataru Uchida, Rinako Iseki, Koji Kamagata, Shigeki Aoki, Tadafumi Kato   +6 more
doaj   +1 more source

Altered Glymphatic‐Related MRI Metrics and Brain Network Reorganization in Drug‐Naive Children With Self‐Limited Epilepsy With Centrotemporal Spikes

CNS Neuroscience &Therapeutics, Volume 32, Issue 8, August 2026.
Drug‐naive children with SeLECTS exhibit altered glymphatic‐related MRI metrics, including reduced gBOLD‐CSF coupling and increased FW‐WM, together with disrupted functional network topology. The gBOLD‐CSF coupling is associated with nodal properties in key regions and with cognitive performance. These findings suggest that impaired brain clearance and
Yu Luo, Xiaoling Zhou, Jiajia Xu, Hua Lai, Qiang Lei, Yuwei Chen, Heng Liu   +6 more
wiley   +1 more source

White matter abnormalities in patients with focal cortical dysplasia revealed by diffusion tensor imaging (DTI) analysis in a voxelwise approach

Frontiers in Neurology, 2012
Background: Diffusion tensor imaging (DTI) allows the analysis of changes in microstructure, through the quantification of the spread and direction of water molecules in tissues.
Viviane Carvalho Fonseca, Clarissa Lin Yasuda, Guilherme Garlipp Tedeschi, Luiz Eduardo eBetting, Fernando eCendes   +4 more
doaj   +1 more source

Multimodel Diffusion MRI Signatures in Atypical Parkinsonian Disorders

Human Brain Mapping, Volume 47, Issue 11, 01 August 2026.
We implemented a diffusion MRI framework to analyze clinically compatible multishell data across 123 participants, including controls, Parkinson's disease (PD), corticobasal syndrome (CBS), and progressive supranuclear palsy Richardson's syndrome (PSP‐RS). Diffusion models included DTI, free‐water elimination (FWE), NODDI, and fixel‐based analysis (FBA)
Yuqi Tian, Farwa Ali, Mary M. Machulda, Val. J. Lowe, Keith A. Josephs, Jennifer L. Whitwell   +5 more
wiley   +1 more source

Cross‐Vendor Validation of Proton Density Fat Fraction and T1 Mapping Using a Combined Proton Density Fat Fraction—T1 Phantom

Journal of Magnetic Resonance Imaging, Volume 64, Issue 2, Page 482-492, August 2026.
ABSTRACT Background In chronic liver disease, fat and fibroinflammatory changes often coexist. However, their biomarkers, proton density fat fraction (PDFF) and T1, are typically assessed separately. Their reproducibility under mutual confounding remains unclear.
Jitka Starekova, Sebastian Weingärtner, David R. Rutkowski, Garrett C. Fullerton, Won C. Bae, Hung P. Do, Ananth J. Madhuranthakam, Vadim Malis, Sheng Qing Lin, Suraj D. Serai, Takeshi Yokoo, Scott B. Reeder, Jean H. Brittain, Diego Hernando   +13 more
wiley   +1 more source

Restriction‐Weighted Q‐Space Trajectory Imaging (ResQ): Toward Mapping Diffusion‐Time Effects With Tensor‐Valued Diffusion Encoding in Human Prostate Cancer Xenografts

NMR in Biomedicine, Volume 39, Issue 8, August 2026.
Tensor‐valued diffusion MRI enables microstructure characterization but can be confounded by the presence of restricted diffusion. We introduce ResQ, a framework that incorporates restriction weighting into q‐space trajectory imaging and we evaluate it in a longitudinal study of prostate cancer xenografts treated by external radiotherapy. ResQ revealed
Filip Szczepankiewicz, Malwina Molendowska, Samo Lasič, Marcella E. Safi, Michael Gottschalk, Evangelia Sereti, Anders Bjartell, Linda Knutsson, Oskar Vilhelmsson Timmermand, Crister Ceberg, Joanna Strand   +10 more
wiley   +1 more source