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Modulation of platelet function by free radicals and free-radical scavengers
Trends in Pharmacological Sciences, 1993Platelets have the capacity to generate oxygen-derived free radicals and are often present at inflammatory foci with other free-radical-generating cells such as white blood cells. Free radicals can modify platelet adhesion and aggregation directly or through effects on the vascular endothelium, which generates prostacyclin and nitric oxide.
D, Salvemini, R, Botting
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Trends in Neurosciences, 2004
Aging is characterized by decrements in maximum function and accumulation of mitochondrial DNA mutations, which are best observed in organs such as the brain that contain post-mitotic cells. Oxygen radicals are increasingly considered responsible for part of these aging changes.
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Aging is characterized by decrements in maximum function and accumulation of mitochondrial DNA mutations, which are best observed in organs such as the brain that contain post-mitotic cells. Oxygen radicals are increasingly considered responsible for part of these aging changes.
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The need for a ?free radical initiative'
Diabetologia, 1996The article presented by Drs. Paolisso and Giugliano discusses the possible relationship between oxidative stress and insulin action. The hypothesis formulated by the authors is that oxidative stress can impair insulin action through a change in the physical state of the plasma membrane of target cells, an increase in intracellular calcium content and ...
COMINACINI, Luciano +2 more
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Seminars in Reproductive Medicine, 1998
Partial reduction of molecular oxygen can generate reactive oxygen species (ROS), including the hydrogen peroxide, and the free radicals superoxide and hydroxyl. The formation of ROS is a feature of many degenerative diseases, such as atherosclerosis and neurodegeneration, Organisms contain a battery of defense mechanisms to prevent the formation of ...
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Partial reduction of molecular oxygen can generate reactive oxygen species (ROS), including the hydrogen peroxide, and the free radicals superoxide and hydroxyl. The formation of ROS is a feature of many degenerative diseases, such as atherosclerosis and neurodegeneration, Organisms contain a battery of defense mechanisms to prevent the formation of ...
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The Significance of Free Radicals and Free Radical Scavengers in L1210 Leukemia
1988L1210 leukemia is a murine leukemia which is associated with anemia and marked neutrophilia. In order to determine the significance of free radicals (FR) in this disorder, we determined the presence and localization of free radical scavengers (FRS) and scavenger-like systems in L1210 leukemia cells obtained in vivo and from in vitro cultures.
A C, Brown, J D, Lutton
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Biochimica et Biophysica Acta (BBA) - Specialized Section on Biophysical Subjects, 1964
N K, KING, F D, LOONEY, M E, WINFIELD
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N K, KING, F D, LOONEY, M E, WINFIELD
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