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Suppression of the formation of megamitochondria by scavengers for free radicals
Molecular Aspects of Medicine, 1997In the present study we have attempted to suppress the formation of megamitochondria by scavengers for free radicals since conditions for the formation of megamitochondria are often intimately related to the generation of free radicals. We employed three different experimental conditions to induce megamitochondria in the liver: ethanol, hydrazine and ...
T, Wakabayashi +5 more
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Probucol, a superoxide free radical scavenger in vitro
Atherosclerosis, 1991Free radical (FR) mediated oxidation of low density lipoproteins (LDL) has been implicated in atherogenesis. Probucol is a lipid lowering agent with antioxidant properties which may protect the LDL from FR mediated damage. The specific mechanism by which probucol acts as an antioxidant has not previously been reported.
Bridges, A.B. +2 more
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Prevention of testicular damage by free-radical scavengers
Urology, 1997The role of free radicals as mediators of ischemic injury to the testicle has been the subject of much investigation. We studied whether the testicular damage induced in the rat by cadmium chloride (CdCl2) can be prevented by administration of free-radical scavengers.Sprague-Dawley rats (n = 45) were divided into 9 groups as follows: a negative control
A, Agarwal, I, Ikemoto, K R, Loughlin
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1994
Free radical chemistry is characterized by an unregulated chain reaction of sequential oxidations and reductions that can rapidly amplify the concentration of reactive radicals. The free radical is defined by the occurrence of an unpaired electron in an organic molecule or metal ion (Halliwell & Gutteridge, 1989).
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Free radical chemistry is characterized by an unregulated chain reaction of sequential oxidations and reductions that can rapidly amplify the concentration of reactive radicals. The free radical is defined by the occurrence of an unpaired electron in an organic molecule or metal ion (Halliwell & Gutteridge, 1989).
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Indole-3-carbinol as a scavenger of free radicals
IUBMB Life, 1996The ability of indole-3-carbinol (indole-3-methanol) to trap a metastable synthetic-free radical is presented. Indole-3-carbinol is capable of acting as a scavenger of free radicals in an in vitro system. The presence of indole-3-carbinol determines the disappearance of the free radicals, the reaction being time- and concentration-dependent.
M B, Arnao, J, Sanchez-Bravo, M, Acosta
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Salvage of skeletal muscle with free radical scavengers
Journal of Vascular Surgery, 1987Extensive skeletal muscle necrosis may occur after prolonged ischemia to the lower extremity, with serious consequences both locally and systemically. The extent of necrosis is a combination of cellular damage that occurs during both the period of ischemia and the period of reperfusion.
P M, Walker +4 more
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Oxygen Free Radicals and Radical Scavengers in Neurology
1990Free radicals have become fashionable in recent years. Hundreds of articles and many regional and national meetings have been devoted to them. The first international symposium on free radicals will take place this year in Vienna. Free radicals seem to be involved in one way or another in many diseases, such as cancer, ischemia, circulatory shock ...
H. E. Kaeser, H. Langemann
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Serum urate as a free radical scavenger in diabetics
Journal of Medical Systems, 1993We have looked at the relationship between serum urate and the molar equivalent serum antioxidant capacity (MESA) in diabetic and normal individuals who attended St Bartholomew's Hospital diabetic clinic and BUPA Health Screening Centre, London, and have compared serum antioxidant capacity between the two groups.
A, Pearl, A, Hale, T, Whitehead
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Myocardial protection by a cardioselective free radical scavenger
European Journal of Pharmacology, 1994Oxygen-derived free radicals are involved in myocardial reperfusion injury. In the present study MDL 74,405 (S-(-)-3,4-dihydro-6-hydroxy-N,N,N-2,5,7,8-heptamethyl-2H-1-benzo pyran-2-ethanaminium 4-methylbenzenesulfonate), a hydrophilic derivative of alpha-tocopherol, has been shown to inhibit lipid peroxidation in rat brain homogenate, ex vivo lipid ...
M A, Petty +5 more
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Biology of free radical scavengers: an evaluation of ascorbate
The FASEB Journal, 1993Reactive free radical species (R ∗ ) are associated with several forms of tissue damage and disease, and also with the process of aging. Protection is thought to be available in the form of endogenous compounds that react with and thereby “scavenge” the R ∗
R C, Rose, A M, Bode
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