Results 31 to 40 of about 4,306 (172)

Loss‐of‐Function Variants in CCDC189 Cause Human Oligoasthenoteratozoospermia by Disrupting Sperm Flagellar and Acrosomal Architecture

Andrology, EarlyView.
ABSTRACT Background Oligoasthenoteratozoospermia (OAT), characterized by reduced sperm count, impaired motility, and abnormal morphology, is a major cause of male infertility with substantial genetic heterogeneity. However, the underlying genetic etiology remains unresolved in a large proportion of affected individuals.
Jianteng Zhou, Ghulam Mustafa, Tingting Lin, Jingwei Ye, Huan Zhang, Hanwei Jiang, Kexin Yang, Guoning Huang, Qinghua Shi   +8 more
wiley   +1 more source

Systemic, Lifestyle and Environmental Modifying Factors in the Pathogenesis of Periodontitis

Journal of Periodontal Research, EarlyView.
A variety of impacting factors in the pathogenesis of periodontitis exist, including systemic, lifestyle, and environmental factors. This review highlights the manifold mechanistic aspects of the link between the pathogenesis of periodontitis, addressing these numerous factors to supplement the long‐standing knowledge of the progression of the disease.
Sabine Elisabeth Groeger, Yuxi Zhou, Jiawen Yong, Lei Wang, Sabine Ruf, Joerg Meyle   +5 more
wiley   +1 more source

Symphonic Gift: Wagner's Siegfried Idyll and the Hermeneutics of Sonata Form

Music Analysis, EarlyView.
ABSTRACT This article reimagines the place of programmatic interpretation within the New Formenlehre through the case study of Richard Wagner's Siegfried Idyll. To theorise the interaction between form and programme, I reconcile ‘separation’ and ‘conflation’ views – as represented by Julian Horton (2020) and Lawrence Kramer (2004a) – by deploying ...
RAFAEL ECHEVARRIA
wiley   +1 more source

Runs of Homozygosity and NetView analyses provide new insight into the genome-wide diversity and admixture of three German cattle breeds.

PLoS ONE, 2019
Angler (RVA) and Red-and-White dual-purpose (RDN) cattle were in the past decades crossed with influential Red Holstein (RH) sires. However, genome-wide diversity studies in these breeds are lacking.
Sowah Addo, Stefanie Klingel, Dirk Hinrichs, Georg Thaller   +3 more
doaj   +1 more source

Genome-wide detection of genetic structure and runs of homozygosity analysis in Anhui indigenous and Western commercial pig breeds using PorcineSNP80k data

BMC Genomics, 2022
Background Runs of homozygosity (ROH) are continuous homozygous regions typically located in the DNA sequence of diploid organisms. Identifications of ROH that lead to reduced performance can provide valuable insight into the genetic architecture of ...
Yao Jiang, Xiaojin Li, Jiali Liu, Wei Zhang, Mei Zhou, Jieru Wang, Linqing Liu, Shiguang Su, Fuping Zhao, Hongquan Chen, Chonglong Wang   +10 more
doaj   +1 more source

Characterization of Lipizzan Horse Population From Lipica Stud Using Molecular and Pedigree Data

Animal Genetics, Volume 57, Issue 4, August 2026.
ABSTRACT In this study, we analysed genetic diversity, population structure and inbreeding in the Lipica Stud Farm population by integrating pedigree records, microsatellite (STR) and genome‐wide SNP data generated using the GGP Equine 70K BeadChip. The dataset comprised 233 horses from the Lipica Stud Farm, which served as the reference population for
Tamara Ferme, Minja Zorc, Marko Cotman, Matjaž Mesarič, Peter Dovč   +4 more
wiley   +1 more source

Persistence of autozygosity in crossbreds between autochthonous and cosmopolitan breeds of swine: a simulation study

Animal
Crossbreeding might be a valid strategy to valorize local pig breeds. Crossbreeding should reduce homozygosity and, as a consequence, yield hybrid vigor for fitness and production traits.
Maria Chiara Fabbri, Emmanuel Lozada-Soto, Francesco Tiezzi, Marjeta Čandek-Potokar, Samuele Bovo, Giuseppina Schiavo, Luca Fontanesi, Maria Muñoz, Cristina Ovilo, Riccardo Bozzi   +9 more
doaj   +1 more source

Pedigree and genome-based patterns of homozygosity in the South African Ayrshire, Holstein, and Jersey breeds

Frontiers in Genetics, 2023
The erosion of genetic diversity limits long-term genetic gain and impedes the sustainability of livestock production. In the South African (SA) dairy industry, the major commercial dairy breeds have been applying estimated breeding values (EBVs) and/or ...
Carina Visser, Simon Frederick Lashmar, Jason Reding, Donagh P. Berry, Donagh P. Berry, Esté van Marle-Köster   +5 more
doaj   +1 more source

Inbreeding and Demographic History of Caribou (Rangifer tarandus) in Western Canada Inferred From Genome‐Wide SNP Data

Evolutionary Applications, Volume 19, Issue 8, August 2026.
ABSTRACT Assessing genetic diversity is essential for conserving endangered populations, yet comprehensive genomic evaluations remain limited for many declining species. Here, we investigated inbreeding levels and effective population sizes (Ne) of caribou (Rangifer tarandus) in western Canada, where populations have experienced pronounced declines ...
Charlotte Bourbon, Samuel Deakin, Anita Michalak, Margaret M. Hughes, Maria Cavedon, Lalenia Neufeld, Agnès Pelletier, Jean Polfus, Helen Schwantje, Caeley Thacker, Marco Musiani, Jocelyn Poissant   +11 more
wiley   +1 more source

Genomic measures of inbreeding in the Norwegian–Swedish Coldblooded Trotter and their associations with known QTL for reproduction and health traits

Genetics Selection Evolution, 2019
Background Since the 1950s, the Norwegian–Swedish Coldblooded trotter (NSCT) has been intensively selected for harness racing performance. As a result, the racing performance of the NSCT has improved remarkably; however, this improved racing performance ...
Brandon D. Velie, Marina Solé, Kim Jäderkvist Fegraeus, Maria K. Rosengren, Knut H. Røed, Carl-Fredrik Ihler, Eric Strand, Gabriella Lindgren   +7 more
doaj   +1 more source