Fructose-1,6-bisphosphate and aldolase mediate glucose sensing by AMPK [PDF]
Nature, 2017 葡萄糖是生物中最基本、最主要的营养物质，它不仅是机体能量的主要来源，也是生物质合成的主要原料。因此，葡萄糖的水平对于生物体是极其重要的。然而，在生活中，体内葡萄糖水平的波动是十分常见的，这是因为我们不可能每时每刻都在摄入葡萄糖：睡一大觉、剧烈运动几个小时或者太忙了没时间吃饭，都会引起葡萄糖水平的显著下降。这时，机体能够触发一套有效的过程应对这类“不利情况”，其中最为关键的就是激活“代谢的核心调节”——AMPK。在葡萄糖水平下降时，被激活的AMPK能够迅速启动脂肪、蛋白质的分解代谢，关闭它们的合成代谢 ...
Chen-Song Zhang, Mengqi Li, Zhichao Wang
exaly +4 more sources
Disruption of Erythritol Catabolism via the Deletion of Fructose-Bisphosphate Aldolase (Fba) and Transaldolase (Tal) as a Strategy to Improve the Brucella Rev1 Vaccine. [PDF]
Int J Mol SciElizalde-Bielsa A +5 more
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Molecular Characterization of Fructose-1,6-bisphosphate Aldolase From Trichinella spiralis and Its Potential in Inducing Immune Protection [PDF]
Frontiers in Cellular and Infection Microbiology, 2019 Trichinella spiralis is a major food-borne parasite worldwide. Trichinellosis caused by T. spiralis is not only a public health problem, but also an economic hazard in food safety. The development of effective vaccines to prevent Trichinella infection in
Yong Yang +9 more
doaj +2 more sources
Structure of fructose bisphosphate aldolase fromBartonella henselaebound to fructose 1,6-bisphosphate [PDF]
Acta Crystallographica Section F Structural Biology and Crystallization Communications, 2011 Fructose bisphosphate aldolase (FBPA) enzymes have been found in a broad range of eukaryotic and prokaryotic organisms. FBPA catalyses the cleavage of fructose 1,6-bisphosphate into glyceraldehyde 3-phosphate and dihydroxyacetone phosphate. The SSGCID has reported several FBPA structures from pathogenic sources, including the bacterium Brucella ...
A.S. Gardberg +4 more
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Melatonin Improves Salt Tolerance in Tomato Seedlings by Enhancing Photosystem II Functionality and Calvin Cycle Activity [PDF]
PlantsSalt stress severely impairs photosynthesis and development in tomato seedlings. This study investigated the regulatory role of exogenous melatonin (MT) on photosynthetic performance under salt stress by determining chlorophyll content, chlorophyll a ...
Xianjun Chen +6 more
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Molecular modeling of inhibitors against fructose bisphosphate aldolase from Candida albicans. [PDF]
In Silico Pharmacol, 2018 Candida albicans is an opportunistic pathogen that causes from vulvovaginal and oropharyngeal candidiasis to systemic infections. The enzyme 1,6-fructose bisphosphate aldolase class II (FBA II), is a macromolecule existing only in lower organisms, being essential for the survival of the pathogen due to its function of maintaining the glycolysis process.
de Amorim AL +5 more
europepmc +4 more sources
Network Basis for the Heat-Adapted Structural Thermostability of Bacterial Class II Fructose Bisphosphate Aldolase. [PDF]
ACS Omega, 2023 The sufficient structural thermostability of a biological macromolecule is an overriding need for green nanoreactors and nanofactories to secure high activity. However, little is still known about what specific structural motif is responsible for it. Here, graph theory was employed to examine if the temperature-dependent noncovalent interactions and ...
Wang G.
europepmc +3 more sources
Distinction between Cytosol and Chloroplast Fructose-Bisphosphate Aldolases from Pea, Wheat, and Corn Leaves [PDF]
Plant Physiology, 1986 A reinvestigation of cytosol and chloroplast fructose-1,6-bisphosphate (FBP) aldolases from pea (Pisum sativum L.), wheat (Triticum aestivum L.) and corn leaves (Zea mays L.) revealed that the two isoenzymes can be separated by chromatography on diethylaminoethyl (DEAE)-cellulose although the separation was often less clear-cut than for the two ...
Claus Schnarrenberger, Ingo Krüger
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Degradation of native and modified forms of fructose-bisphosphate aldolase microinjected into HeLa cells [PDF]
Biochemical Journal, 1988 The uptake and degradation of radiolabelled rabbit muscle fructose-bisphosphate aldolase (EC 4.1.2.13) was studied in HeLa cells microinjected by the erythrocyte ghost fusion system. Labelled aldolase was progressively modified by treatment with GSSG or N-ethylmaleimide (NEM) before microinjection to determine whether these agents, which inactivate and
M F Hopgood +3 more
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Structures, characteristics and functions of fructose-1,6-bisphosphate aldolase in various tissues
Acta Societatis Botanicorum Poloniae, 2023 Aldolase exhibits multiple functions in a variety of organisms, including fungi, unicellular algae and plants, and so on. Furthermore, different isoforms of fructose 1,6-bisphosphate aldolase (FBA) exhibit significantly different characteristics and ...
Lina Yang +4 more
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