Results 41 to 50 of about 12,022 (131)

A BioLiving Periosteum Evokes Centripetal Regeneration in Challenging Bone Defects

Advanced Science, Volume 13, Issue 26, 8 May 2026.
Large bone defects often suffer from insufficient central healing. This study engineers a BioLiving periosteum that mimics the native structure. It sequentially delivers remote chemical cues and contact physical cues in a signaling‐relay manner, effectively recruiting and guiding endogenous cells toward the defect center.
Yang Shi, Nian Liu, Jingyi Gu, Yinling Wang, Weiye Wang, Zhiwei Ke, Mingjun Xie, Wenjing Jin, Weicheng Kong, Jue Shi, Hui Pan, Yong He, Zhijian Xie   +12 more
wiley   +1 more source

Deep Proteomic Profiles of the Antarctic Diatom Fragilariopsis Cylindrus Under Varying Iron and Manganese Conditions

PROTEOMICS, Volume 26, Issue 5, Page 112-119, May 2026.
ABSTRACT Fragilariopsis cylindrus is a key diatom in the Southern Ocean, where low iron and manganese availability constrain primary production and biogeochemical activity. The molecular mechanisms used by polar diatoms, including F. cylindrus, to cope with trace metal limitations remain largely unexplored.
Loay J. Jabre, Elden Rowland, J. Scott P. McCain, Erin M. Bertrand   +3 more
wiley   +1 more source

In silico study of 4-phosphorylated derivatives of 1,3-oxazole as inhibitors of Candida albicans fructose-1,6-bisphosphate aldolase II

Heliyon, 2019
In this study, the synthesis, in vitro anti-Candida activity and molecular modeling of 4-phosphorylated derivatives of 1,3-oxazole as inhibitors of Candida albicans fructose-1,6-bisphosphate aldolase (FBA-II) are demonstrated and discussed.
Ivan V. Semenyuta, Oleksandr L. Kobzar, Diana M. Hodyna, Volodymyr S. Brovarets, Larysa O. Metelytsia   +4 more
doaj   +1 more source

SiFBA5, a cold-responsive factor from Saussurea involucrata promotes cold resilience and biomass increase in transgenic tomato plants under cold stress

BMC Plant Biology, 2021
Background Saussurea involucrata survives in extreme arctic conditions and is very cold-resistant. This species grows in rocky, mountainous areas with elevations of 2400–4100 m, which are snow-covered year-round and are subject to freezing temperatures ...
Jianqiang Mu, Yajuan Fu, Bucang Liu, Yao Zhang, Aiying Wang, Yuxia Li, Jianbo Zhu   +6 more
doaj   +1 more source

Identification of hub genes in the fructose-1, 6 bisphosphate 1-protein interaction network based on differential expression, and survival impact on hepatocellular carcinoma patients

Biomedical and Biotechnology Research Journal, 2023
Background: Hepatocytes, the cells of origin in hepatocellular carcinoma (HCC), accompany several altered metabolic pathways leading to adaptive metabolic switch and uncontrolled cell proliferation.
Bhavya Dawath, Harshal Patole, Norine Dsouza, Kripa Purohit, Shiney Peter   +4 more
doaj   +1 more source

APOE4 Drives Sex‐ and Diet‐Dependent Effects on AD‐Like Pathology, Cognition, and Mitochondrial Function

FASEB BioAdvances, Volume 8, Issue 5, May 2026.
APOE4 interacts with sex and diet to influence brain mitochondrial function. ABSTRACT Apolipoprotein E4 (APOE4) is the strongest genetic risk factor for Alzheimer's disease (AD), yet it's unclear how this allele promotes disease. While factors like diet and sex may modify AD susceptibility in APOE4 carriers, the interaction between these factors is ...
Chelsea N. Johnson, Colton R. Lysaker, Xin Cao, Vivien Csikos, Frederick Boakye, Paul J. Kueck, Edziu Franczak, Paige C. Geiger, Jill K. Morris, John P. Thyfault, Heather M. Wilkins   +10 more
wiley   +1 more source

OSA Initiates Histone Lactylation That Drives PDE4B/FUS/AGT Axis to Pulmonary Hypertension

Cell Proliferation, Volume 59, Issue 5, May 2026.
This study illustrates how chronic intermittent hypoxia (CIH) in obstructive sleep apnea (OSA) leads to hypertension via increased oxidative stress and mitochondrial dysfunction in pulmonary artery smooth muscle cells (PASMCs), causing glycolytic dysregulation. Lactate accumulation enhances histone lactylation, upregulating phosphodiesterase 4B (PDE4B),
Li Yang, Qing Ni, Yan He, Shijie Liu, Lulu Gan, Anni Dai, Yang Hu, Qian Liu, Xueling Yang, Jiqian Li, Yi Tao, Yunyu Li, Mingyue Xu   +12 more
wiley   +1 more source

Molecular And 3D-Structural Characterization Of Fructose-1,6-Bisphosphate Aldolase Derived From Metroxylon Sagu

Brazilian Archives of Biology and Technology, 2017
Fructose-1,6-bisphosphate aldolase (FBAld) is an enzyme that catalyzes the cleavage of D-fructose-1,6-phosphate (FBP) to D-glyceraldehyde-3-phosphate (G3P) and dihydroxyacetone phosphate (DHAP), and plays vital role in glycolysis and gluconeogenesis ...
Hairul Azman Roslan, Md. Anowar Hossain, Jerry Gerunsin   +2 more
doaj   +1 more source

Molecular Phylogeny and Strain Genotyping of the Bacterial Endosymbiont Wolbachia Associated With Tuta absoluta Populations

Entomologia Experimentalis et Applicata, Volume 174, Issue 5, Page 387-397, May 2026.
This study was designed to understand the association between reproductive endosymbiotic bacteria and wild and laboratory‐reared Tuta absoluta populations. The majority of T. absoluta populations showed Wolbachia presence at varying levels of infection, whereas Arsenophonus, Cardinium, and Spiroplasma were not detected. Wolbachia‐positive T.
Ashok B. Hadapad, Arpit Prashar, Vikas G. C. Rana, Basavaraj S. Kalmath, Sridhar Vaddi, Ramesh S. Hire   +5 more
wiley   +1 more source

Mass Spectrometry Imaging Combined With Single‐Cell Transcriptional Profiling Reveals the Multidimensional Spatial Distributions and Biosynthetic Pathways of Medicinal Components in Andrographis paniculata

Plant Biotechnology Journal, Volume 24, Issue 5, Page 2876-2890, May 2026.
ABSTRACT The synthesis and accumulation of active ingredients in medicinal plants are distributed in specific organs, tissues, and cell types, which are important for the exploitation of medicinal plants. However, the fine distribution of active ingredients is difficult to know. Here, the system of mass spectrometry imaging (MSI) integrated with single‐
HaiSheng Zeng, MeiHui Shi, ZhiRong Chen, XueJing Sun, HuiJie Zhang, Yue Huang, YuCheng Chen, Jun Ren, HuiLing Huang, Almaz Borjigidai, Man Zhang, SuJuan Duan, Yi‐Jun Chen, Hong‐Lei Jin, Hong‐Bin Wang   +14 more
wiley   +1 more source