Results 11 to 20 of about 30,141 (201)

Examining the language and behavioural profile in FTD and ALS-FTD [PDF]

Journal of Neurology, Neurosurgery & Psychiatry, 2017
A proportion of patients with behavioural variant frontotemporal dementia (bvFTD) develop amyotrophic lateral sclerosis (ALS). It is currently unknown whether the behavioural and cognitive syndrome in bvFTD with ALS (ALS-FTD) is indistinguishable from that of bvFTD alone.A retrospective cohort of 241 patients with clinical diagnoses of bvFTD (n=185) or
Saxon, Jennifer A., Thompson, Jennifer C., Jones, Matthew, Harris, Jennifer M., Richardson, Anna M.T., Langheinrich, Tobias, Neary, David, Mann, David M.A., Snowden, Julie S.   +8 more
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Japanese version of the ALS-FTD-Questionnaire (ALS-FTD-Q-J)

Journal of the Neurological Sciences, 2016
Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) share common clinical, genetic and neuropathological features. Some ALS patients have behavioral/personality changes, which could result in significant obstacles in the care provided by family members and caregivers.
Watanabe, Y., Beeldman, E., Raaphorst, J., Izumi, Y., Yoshino, H., Masuda, M., Atsuta, N., Ito, S., Adachi, T., Adachi, Y., Yokota, O., Oda, M., Hanashima, R., Ogino, M., Ichikawa, H., Hasegawa, K., Kimura, H., Shimizu, T., Aiba, I., Yabe, H., Kanba, M., Kusumi, K., Aoki, T., Hiroe, Y., Watanabe, H., Nishiyama, K, Nomoto, M., Sobue, G., Nakashima, K.   +28 more
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Neurobiology of FTD

, 2017
Abstract Frontotemporal dementia (FTD) is the third most common form of dementia, and is one that predominantly affects the frontal and temporal lobes. Pathological heterogeneity of FTD is highlighted in various types of protein inclusions in the brain, which can include tau, TDP-43, or FUS.
Dah-Eun Chloe Chung, Jeannette N. Stankowski, Leonard Petrucelli   +2 more
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SnapShot: Genetics of ALS and FTD

Cell, 2015
Frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) are considered to be part of a spectrum. Clinically, FTD patients present with dementia frequently characterized by behavioral and speech problems. ALS patients exhibit alterations of voluntary movements caused by degeneration of motor neurons.
Guerreiro, Rita, Brás, José, Hardy, John   +2 more
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“The DESCRIBE-ALS-FTD study: a prospective multicenter observational study of the ALS-FTD spectrum” [PDF]

Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration
Background: Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) exhibit significant clinical, genetic and neuropathological abnormalities, and are regarded as belonging to a common disease spectrum, referred to as the ALS-FTD spectrum disorders.
Hermann, Andreas, Prudlo, Johannes, Bürger, Katharina, Höglinger, Günter U, Levin, Johannes, Düzel, Emrah, Teipel, Stefan, Beichert, Lukas, Brosseron, Frederic, Wagner, Michael, Frommann, Ingo, Ramirez, Alfredo, Kasper, Elisabeth, Yakupov, Renat, Schmid, Matthias, Lingor, Paul, Haass, Christian, DESCRIBE-ALS, consortium, DESCRIBE-FTD, Spottke, Annika, Günther, René, Weydt, Patrick, Neumann, Manuela, Synofzik, Matthis, Schneider, Anja, Peters, Oliver, Priller, Josef, Dinter, Elisabeth, Wiltfang, Jens, Zerr, Inga, Flöel, Agnes   +30 more
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FTD and ALS: Genetic Ties that Bind [PDF]

Neuron, 2011
Curiously, amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), seemingly disparate neurodegenerative disorders, can be inherited together. Two groups (DeJesus-Hernandez et al. and Renton et al.) show that the long sought after ALS/FTD mutation on chromosomal region 9p is a hexanucleotide expansion in C90RF72.
Orr, Harry T., Harry T. Orr
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Immune-related genetic enrichment in frontotemporal dementia: An analysis of genome-wide association studies.

PLoS Medicine, 2018
BackgroundConverging evidence suggests that immune-mediated dysfunction plays an important role in the pathogenesis of frontotemporal dementia (FTD). Although genetic studies have shown that immune-associated loci are associated with increased FTD risk ...
Iris Broce, Celeste M Karch, Natalie Wen, Chun C Fan, Yunpeng Wang, Chin Hong Tan, Naomi Kouri, Owen A Ross, Günter U Höglinger, Ulrich Muller, John Hardy, International FTD-Genomics Consortium, Parastoo Momeni, Christopher P Hess, William P Dillon, Zachary A Miller, Luke W Bonham, Gil D Rabinovici, Howard J Rosen, Gerard D Schellenberg, Andre Franke, Tom H Karlsen, Jan H Veldink, Raffaele Ferrari, Jennifer S Yokoyama, Bruce L Miller, Ole A Andreassen, Anders M Dale, Rahul S Desikan, Leo P Sugrue   +29 more
doaj   +2 more sources

Roadmap for C9ORF72 in Frontotemporal Dementia and Amyotrophic Lateral Sclerosis: Report on the C9ORF72 FTD/ALS Summit [PDF]

Neurology and Therapy, 2023
A summit held March 2023 in Scottsdale, Arizona (USA) focused on the intronic hexanucleotide expansion in the C9ORF72 gene and its relevance in frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS; C9ORF72-FTD/ALS).
Rita Sattler, Bryan J. Traynor, Janice Robertson, Ludo Van Den Bosch, Sami J. Barmada, Clive N. Svendsen, Matthew D. Disney, Tania F. Gendron, Philip C. Wong, Martin R. Turner, Adam Boxer, Suma Babu, Michael Benatar, Michael Kurnellas, Jonathan D. Rohrer, Christopher J. Donnelly, Lynette M. Bustos, Kendall Van Keuren-Jensen, Penny A. Dacks, Marwan N. Sabbagh, Attendees of the inaugural C9ORF72 FTD/ALS Summit   +20 more
doaj   +2 more sources

Characterizing the Clinical Features and Atrophy Patterns of MAPT-Related Frontotemporal Dementia With Disease Progression Modeling [PDF]

, 2021
BACKGROUND AND OBJECTIVE: Mutations in the MAPT gene cause frontotemporal dementia (FTD). Most previous studies investigating the neuroanatomical signature of MAPT mutations have grouped all different mutations together and shown an association with ...
Borroni, B, Seelaar, H, Moreno, F, Bocchetta, M, Butler, C, Alexander, DC, Young, AL, Convery, RS, Otto, M, Greaves, CV, Jiskoot, L, Genetic FTD Initiative (GENFI), Tartaglia, MC, Ducharme, S, Danek, A, Graff, C, Sanchez-Valle, R, Laforce, R, De Mendonça, A, Van Swieten, J, Tagliavini, F, Williams, SCR, Rohrer, JD, Cash, DM, Santana, I, Russell, LL, Gerhard, A, Galimberti, D, Vandenberghe, R, Finger, E, Levin, J, Peakman, G, Sorbi, S, Todd, E, Masellis, M, Synofzik, M, Williams, SC, Rowe, JB   +37 more
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Disrupted endoplasmic reticulum-mediated autophagosomal biogenesis in a Drosophila model of C9-ALS-FTD

, 2023
Macroautophagy/autophagy is a major pathway for the clearance of protein aggregates and damaged organelles, and multiple intracellular organelles participate in the process of autophagy, from autophagosome formation to maturation and degradation ...
Hyun Sung (8528688), Thomas E. Lloyd (16890759)   +1 more
core   +1 more source