Results 21 to 30 of about 30,141 (201)

ALS and FTD: an epigenetic perspective [PDF]

Acta Neuropathologica, 2016
Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are two fatal neurodegenerative diseases seen in comorbidity in up to 50 % of cases. Despite tremendous efforts over the last two decades, no biomarkers or effective therapeutics have been identified to prevent, decelerate, or stop neuronal death in patients. While the identification
Veronique V, Belzil, Rebecca B, Katzman, Leonard, Petrucelli   +2 more
openaire   +2 more sources

Frontotemporal Dementia and Glucose Metabolism

Frontiers in Neuroscience, 2022
Frontotemporal dementia (FTD), hallmarked by antero-temporal degeneration in the human brain, is the second most common early onset dementia. FTD is a diverse disease with three main clinical presentations, four different identified proteinopathies and ...
Liam Rodney Garrett, Teresa Niccoli
doaj   +1 more source

Progression of Behavioral Disturbances and Neuropsychiatric Symptoms in Patients with Genetic Frontotemporal Dementia [PDF]

, 2021
Group Information: The Genetic FTD Initiative Group Investigators and Coordinators are listed in Supplement 2 available online at https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2774641#note-ZOI200951-1 .Correction: This article was ...
Brattini, C, Funkiewiez, A, Heller, C, Bocchetta, M, Castelo-Branco, M, Giaccone, G, Karnath, HO, Bender, B, Colliot, O, Jelic, V, Bras, J, Arighi, A, Benussi, A, Rohrer, JD, Santana, I, Indakoetxea, B, Lombardi, G, Levin, J, Brice, A, De Arriba, M, Kuchcinski, G, Masellis, M, Benussi, L, Caroppo, P, Synofzik, M, Afonso, S, Bertrand, A, Cope, T, Borroni, B, Antonell, A, Van Swieten, JC, Cash, D, Archetti, S, Borrego-Ecija, S, Laforce, R, De Mendonça, A, Convery, R, Tartaglia, C, Fumagalli, G, Galimberti, D, Gabilondo, A, Peakman, G, Bertoux, M, Bessi, V, Black, S, Barandiaran, M, Gazzina, S, Leitão, MJ, Otto, M, Fox, N, Ghidoni, R, Di Fede, G, Bargalló, N, Jiskoot, L, Hoegen, T, Ducharme, S, Danek, A, Sanchez-Valle, R, Guerreiro, R, Freedman, M, Balasa, M, Duro, D, Gasparotti, R, Finger, E, Alberici, A, Fenoglio, C, Deramecourt, V, Ferreira, CB, Todd, E, Binetti, G, Díez, A, Cosseddu, M, Almeida, MR, Rowe, JB, Le Ber, I, Frisoni, G, Bruffaerts, R, Andersson, C, Cañada, M, Moreno, F, Ferrari, C, Bonomi, E, Keren, R, Lladó, A, Bartha, R, Graff, C, Greaves, C, Camuzat, A, Tagliavini, F, Gorostidi, A, Butler, CR, Gerhard, A, Langheinrich, T, Vandenberghe, R, Lebouvier, T, Sorbi, S, Gauthier, S, Pasquier, F, Anderl-Straub, S, Premi, E   +99 more
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Inflammation in ALS/FTD pathogenesis [PDF]

Acta Neuropathologica, 2018
Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are neurodegenerative diseases that overlap in their clinical presentation, pathology and genetics, and likely represent a spectrum of one underlying disease. In ALS/FTD patients, neuroinflammation characterized by innate immune responses of tissue-resident glial cells is uniformly ...
Madelyn E. McCauley, Robert H. Baloh
openaire   +2 more sources

Ensino de Geografia: um ensaio sobre seus desafios

Revista Movimentos Sociais e Dinâmicas Espaciais, 2017
O objetivo deste ensaio é o de refletir sobre o ensino de Geografia, realizando um breve apanhado dos seus atuais desafios. Para tanto, recorre-se a um breve levantamento bibliográfico, onde se pontua a atualidade do pensamento geográfico, as tendências
Otávio Augusto Alves dos Santos
doaj   +1 more source

Social Cognition Deficits Are Pervasive across Both Classical and Overlap Frontotemporal Dementia Syndromes

Dementia and Geriatric Cognitive Disorders Extra, 2020
Objectives: Frontotemporal dementia (FTD) syndromes are a complex group of disorders characterised by profound changes in behaviour and cognition. Many of the observed behavioural abnormalities are now recognised to be due to impaired social cognition ...
Faheem Arshad, Avanthi Paplikar, Shailaja Mekala, Feba Varghese, Vandana Valiyaparambath Purushothaman, Darshini Jeevandra Kumar, Leena Shingavi, Seena Vengalil, Subasree Ramakrishnan, Ravi Yadav, Pramod Kumar Pal, Atchayaram Nalini, Suvarna Alladi   +12 more
doaj   +1 more source

Frontotemporal Dementia in Southeast Asia: A Comparative Study

Dementia and Geriatric Cognitive Disorders Extra, 2013
Background: The clinical profile of frontotemporal dementia (FTD) in Southeast Asia is not known. We characterized and compared the demographic and clinical characteristics of FTD patients in Southeast Asia with North Asian and Western patients. Methods:
Yee-Leng Tan, Amanda Ng, Nagaendran Kandiah   +2 more
doaj   +1 more source

Serum total TDP-43 levels are decreased in frontotemporal dementia patients with C9orf72 repeat expansion or concomitant motoneuron disease phenotype

Alzheimer’s Research & Therapy, 2022
Background Frontotemporal dementia (FTD) covers a spectrum of neurodegenerative disorders with various clinical and neuropathological subtypes. The two major pathological proteins accumulating in the brains of FTD patients, depending on their genetic ...
Kasper Katisko, Nadine Huber, Tarja Kokkola, Päivi Hartikainen, Johanna Krüger, Anna-Leena Heikkinen, Veera Paananen, Ville Leinonen, Ville E. Korhonen, Seppo Helisalmi, Sanna-Kaisa Herukka, Valentina Cantoni, Yasmine Gadola, Silvana Archetti, Anne M. Remes, Annakaisa Haapasalo, Barbara Borroni, Eino Solje   +17 more
doaj   +1 more source

Italian Frontotemporal Dementia Network (FTD Group-SINDEM): sharing clinical and diagnostic procedures in Frontotemporal Dementia in Italy [PDF]

, 2014
In the prospect of improved disease management and future clinical trials in Frontotemporal Dementia, it is desirable to share common diagnostic procedures.
Sorbi, S., Bruni, A. C., Galimberti, D., Padovani, A, Frisoni, Giovanni, R. Turrone, C. Marra, PICCOLI, Tommaso, Ghidoni, R, A. C. Bruni, Borroni, B., Cappa, SF, Daniele, Antonio., Caltagirone, C, Alberici, A., S. F. Cappa, Tremolizzo, L., F. Tagliavini, L. Tremolizzo, Bruni, AC, E. Scarpini, Padovani, A., Tremolizzo, L, Benussi, A, Benussi, A., G. B. Frisoni, Tagliavini, F., Alberici, A, I. Rainero, Marra, C, Ghidoni, R., The FTD Group-SINDEM, Turrone, R., The FTD Group SINDEM, V. Silani, Frisoni, GB, D. Galimberti, A. Alberici, Frisoni, G. B., Borroni, B, C. Caltagirone, Agosta, F, Caltagirone, C., B. Borroni, Scarpini, E., Caffarra, P., R. Ghidoni, Turrone, R, Silani, V, Marra, C., Rainero, I., A. Padovani, Marra, Camillo, Bruni, A C, S. Sorbi, P. Caffarra, Caffarra, P, A. Benussi, Silani, V., Tagliavini, F, Cappa, S F, Nacmias, B., Cappa, S. F., Galimberti, D, CALTAGIRONE, CARLO, Sorbi, S, Nacmias, B, MAURI, MARCO, Rainero, I, B. Nacmias, Scarpini, E   +70 more
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Plasma proteome profiling identifies changes associated to AD but not to FTD

Acta Neuropathologica Communications, 2022
Background Frontotemporal dementia (FTD) is caused by frontotemporal lobar degeneration (FTLD), characterized mainly by inclusions of Tau (FTLD-Tau) or TAR DNA binding43 (FTLD-TDP) proteins.
R. Babapour Mofrad, M. del Campo, C. F. W. Peeters, L. H. H. Meeter, H. Seelaar, M. Koel-Simmelink, I. H. G. B. Ramakers, H. A. M. Middelkoop, P. P. De Deyn, J. A. H. R. Claassen, J. C. van Swieten, C. Bridel, J. J. M. Hoozemans, P. Scheltens, W. M. van der Flier, Y. A. L. Pijnenburg, Charlotte E. Teunissen   +16 more
doaj   +1 more source