The role of the mobile proton in fucose migration [PDF]
Analytical and Bioanalytical Chemistry, 2019 Fucose migration reactions represent a substantial challenge in the analysis of fucosylated glycan structures by mass spectrometry. In addition to the well-established observation of transposed fucose residues in glycan-dissociation product ions, recent ...
Helden, Gert von +7 more
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Significance of fucose in intestinal health and disease [PDF]
Molecular Microbiology, 2021 AbstractThe deoxyhexose sugar L‐fucose is important for many biological processes within the human body and the associated microbiota. This carbohydrate is abundant in host gut mucosal surfaces, numerous microbial cell surface structures, and some dietary carbohydrates.
Jolene M Garber +2 more
exaly +3 more sources
An l-fucose-responsive transcription factor cross-regulates the expression of a diverse array of carbohydrate-active enzymes in Trichoderma reesei. [PDF]
PLoS Geneticsl-Fucose is a universal capping component of biomolecules found throughout all domains of life. Although fungi are renowned for their role in biomass recycling, the mechanisms by which they process l-fucose remain largely unknown.
Qinqin Zhao +6 more
doaj +2 more sources
Marine Drugs, 2011 Fucose-containing sulfated polysaccharides (FCSPs) extracted from seaweeds, especially brown macro-algae, are known to possess essential bioactive properties, notably growth inhibitory effects on tumor cells.
Marcel Tutor Ale, Anne Strunge Meyer
exaly +3 more sources
GDP‐fucose transporter SLC35C1: a potential regulatory role in cytosolic GDP‐fucose and fucosylated glycan synthesis [PDF]
FEBS Open BioGlycosylation occurs mainly in the Golgi apparatus, whereas the synthesis of nucleotide sugars occurs in the cytoplasm or nucleus. GDP‐fucose in mammalian cells could be produced via de novo and salvage pathways in the cytoplasm; the first one is ...
Edyta Skurska, Mariusz Olczak
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Aberrant glycosylation patterns as potential biomarkers for diagnosis and disease progression in bullous pemphigoid [PDF]
Frontiers in ImmunologyObjectivesBullous pemphigoid (BP) is a prototypical autoimmune disease characterized by the production of autoantibodies against hemidesmosomal proteins BP180 and BP230.
Haijun Miao +7 more
doaj +2 more sources
Campylobacter jejuni uses energy taxis and a dehydrogenase enzyme for l-fucose chemotaxis
mBio, 2023 Campylobacter jejuni is a leading cause of bacterial diarrhea worldwide, and infection in infants is associated with growth stunting in low- and middle-income countries. Approximately half of all C. jejuni isolates are asaccharolytic, while the remainder
Bibi Zhou +6 more
doaj +1 more source
Rational design of GDP‑d‑mannose mannosyl hydrolase for microbial l‑fucose production
Microbial Cell Factories, 2023 Background l‑Fucose is a rare sugar that has beneficial biological activities, and its industrial production is mainly achieved with brown algae through acidic/enzymatic fucoidan hydrolysis and a cumbersome purification process.
Cong Fu +9 more
doaj +1 more source
The fucose salvage pathway inhibits invadopodia formation and extracellular matrix degradation in melanoma cells. [PDF]
PLoS ONE, 2018 The fucose salvage pathway is a two-step process in which mammalian cells transform L-fucose into GDP-L-fucose, a universal fucose donor used by fucosyltransferases to modify glycans.
Tyler Keeley +4 more
doaj +1 more source
Gut Microbes, 2023 Intestinal stem cells (ISCs) are critical for the development and rapid turnover of intestinal epithelium. The regulatory effects of gut microbiota and their metabolites on ISCs stemness remain elusive.
Caihan Duan +7 more
doaj +1 more source