FucR Functions as a Transcriptional Regulator for L-Fucose Utilization in Campylobacter jejuni [PDF]
MicroorganismsCampylobacter jejuni is an enteric pathogen and a major cause of foodborne illness worldwide. It has been shown that C. jejuni primarily utilizes amino acids as its preferred energy source, but its ability to utilize L-fucose can grant a competitive ...
Wayne T. Muraoka +6 more
doaj +2 more sources
Fucose sensing regulates bacterial intestinal colonization [PDF]
Nature, 2012 The mammalian gastrointestinal tract provides a complex and competitive environment for the microbiota. Successful colonization by pathogens requires scavenging nutrients, sensing chemical signals, competing with the resident bacteria and precisely regulating the expression of virulence genes.
Matthew K Waldor +2 more
exaly +4 more sources
Insights into fucose metabolism: SLC35C1-independent fucosylation discriminates against mannose-derived GDP-fucose [PDF]
, 2021 Abstract Mutations in the SLC35C1 gene, encoding the Golgi GDP-fucose transporter, cause leukocyte adhesion deficiency II (LADII). Fucosylation improvement in LADII patients treated with fucose suggests the existence of an SLC35C1-independent route of GDP-fucose transport, which still remains a mystery.
Edyta Skurska +5 more
openaire +3 more sources
An l-fucose-responsive transcription factor cross-regulates the expression of a diverse array of carbohydrate-active enzymes in Trichoderma reesei. [PDF]
PLoS Geneticsl-Fucose is a universal capping component of biomolecules found throughout all domains of life. Although fungi are renowned for their role in biomass recycling, the mechanisms by which they process l-fucose remain largely unknown.
Qinqin Zhao +6 more
doaj +2 more sources
GDP-l-fucose Pyrophosphorylase [PDF]
Journal of Biological Chemistry, 1998 Irena Pastuszak +5 more
openaire +3 more sources
Mutation of the GDP-Fucose Biosynthesis Gene <i>gmds</i> Increases Hair Cell Number and Neuromast Regenerative Capacity in Zebrafish. [PDF]
Int J Mol SciAmeen MT, Fowler G, French CR.
europepmc +3 more sources
Campylobacter jejuni uses energy taxis and a dehydrogenase enzyme for l-fucose chemotaxis
mBio, 2023 Campylobacter jejuni is a leading cause of bacterial diarrhea worldwide, and infection in infants is associated with growth stunting in low- and middle-income countries. Approximately half of all C. jejuni isolates are asaccharolytic, while the remainder
Bibi Zhou +6 more
doaj +1 more source
Rational design of GDP‑d‑mannose mannosyl hydrolase for microbial l‑fucose production
Microbial Cell Factories, 2023 Background l‑Fucose is a rare sugar that has beneficial biological activities, and its industrial production is mainly achieved with brown algae through acidic/enzymatic fucoidan hydrolysis and a cumbersome purification process.
Cong Fu +9 more
doaj +1 more source
The fucose salvage pathway inhibits invadopodia formation and extracellular matrix degradation in melanoma cells. [PDF]
PLoS ONE, 2018 The fucose salvage pathway is a two-step process in which mammalian cells transform L-fucose into GDP-L-fucose, a universal fucose donor used by fucosyltransferases to modify glycans.
Tyler Keeley +4 more
doaj +1 more source
Frontiers in Cellular and Infection Microbiology, 2023 IntroductionPrevious studies reported that fucose plays a protective role in inhibiting pathogens. Fusobacterium nucleatum (Fn) was recently found to promote the progression of colitis. However, the effects of fucose on Fn are poorly understood.
Caihan Duan +6 more
doaj +1 more source