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FucR Functions as a Transcriptional Regulator for L-Fucose Utilization in Campylobacter jejuni [PDF]

Microorganisms
Campylobacter jejuni is an enteric pathogen and a major cause of foodborne illness worldwide. It has been shown that C. jejuni primarily utilizes amino acids as its preferred energy source, but its ability to utilize L-fucose can grant a competitive ...
Wayne T. Muraoka, Nicholas Lizer, Peng Liu, Zhangqi Shen, Qingqing Xia, Muslum Ilgu, Qijing Zhang   +6 more
doaj   +2 more sources

An l-fucose-responsive transcription factor cross-regulates the expression of a diverse array of carbohydrate-active enzymes in Trichoderma reesei. [PDF]

PLoS Genetics
l-Fucose is a universal capping component of biomolecules found throughout all domains of life. Although fungi are renowned for their role in biomass recycling, the mechanisms by which they process l-fucose remain largely unknown.
Qinqin Zhao, Liwei Gao, Nuo Xu, Xiuting Zhang, Yuqi Qin, Yinbo Qu, Guodong Liu   +6 more
doaj   +2 more sources

Campylobacter jejuni uses energy taxis and a dehydrogenase enzyme for l-fucose chemotaxis

mBio, 2023
Campylobacter jejuni is a leading cause of bacterial diarrhea worldwide, and infection in infants is associated with growth stunting in low- and middle-income countries. Approximately half of all C. jejuni isolates are asaccharolytic, while the remainder
Bibi Zhou, Jolene M. Garber, Jiri Vlach, Parastoo Azadi, Kenneth K. S. Ng, Jorge C. Escalante-Semerena, Christine M. Szymanski   +6 more
doaj   +1 more source

Rational design of GDP‑d‑mannose mannosyl hydrolase for microbial l‑fucose production

Microbial Cell Factories, 2023
Background l‑Fucose is a rare sugar that has beneficial biological activities, and its industrial production is mainly achieved with brown algae through acidic/enzymatic fucoidan hydrolysis and a cumbersome purification process.
Cong Fu, Xuexia Xu, Yukang Xie, Yufei Liu, Min Liu, Ai Chen, Jenny M. Blamey, Jiping Shi, Suwen Zhao, Junsong Sun   +9 more
doaj   +1 more source

Fucose ameliorates the proinflammatory property of Fusobacterium nucleatum in colitis via altering its metabolism

Frontiers in Cellular and Infection Microbiology, 2023
IntroductionPrevious studies reported that fucose plays a protective role in inhibiting pathogens. Fusobacterium nucleatum (Fn) was recently found to promote the progression of colitis. However, the effects of fucose on Fn are poorly understood.
Caihan Duan, Lingzhi Hou, Xiaohua Deng, Junhao Wu, Wei Qian, Chaoqun Han, Xiaohua Hou   +6 more
doaj   +1 more source

Expanded Proteomic Survey of the Human Parasite Leishmania major Focusing on Changes in Null Mutants of the Golgi GDP-Mannose/Fucose/Arabinopyranose Transporter LPG2 and of the Mitochondrial Fucosyltransferase FUT1

Microbiology Spectrum, 2022
The trypanosomatid protozoan parasite Leishmania has a significant impact on human health globally. Understanding the pathways associated with virulence within this significant pathogen is critical for identifying novel vaccination and chemotherapy ...
Gloria Polanco, Nichollas E. Scott, Lon F. Lye, Stephen M. Beverley   +3 more
doaj   +1 more source

Fucose promotes intestinal stem cell-mediated intestinal epithelial development through promoting Akkermansia-related propanoate metabolism

Gut Microbes, 2023
Intestinal stem cells (ISCs) are critical for the development and rapid turnover of intestinal epithelium. The regulatory effects of gut microbiota and their metabolites on ISCs stemness remain elusive.
Caihan Duan, Junhao Wu, Zhe Wang, Chen Tan, Lingzhi Hou, Wei Qian, Chaoqun Han, Xiaohua Hou   +7 more
doaj   +1 more source

Effects of L-fucose supplementation on the viability of cancer cell lines

Makara Journal of Health Research, 2020
Background: Fucose is a deoxyhexose sugar. While the biological roles of L-fucose remain unclear, the sugar is known to accelerate the malignant potential of cancer cells.
Muhammad Alif Mazlan, Afzan Mat Yusof, Muhammad Lokman Md Isa   +2 more
doaj   +1 more source

Developing a Fluorescent Inducible System for Free Fucose Quantification in Escherichia coli

Biosensors, 2023
L-Fucose is a monosaccharide abundant in mammalian glycoconjugates. In humans, fucose can be found in human milk oligosaccharides (HMOs), mucins, and glycoproteins in the intestinal epithelium.
Samantha Nuñez, Maria Barra, Daniel Garrido   +2 more
doaj   +1 more source

Incorporation of fucose into glycans independent of the GDP-fucose transporter SLC35C1 preferentially utilizes salvaged over de novo GDP-fucose

Journal of Biological Chemistry, 2022
Mutations in the SLC35C1 gene encoding the Golgi GDP-fucose transporter are known to cause leukocyte adhesion deficiency II. However, improvement of fucosylation in leukocyte adhesion deficiency II patients treated with exogenous fucose suggests the existence of an SLC35C1-independent route of GDP-fucose transport, which remains a mystery.
Edyta Skurska, Bożena Szulc, Dorota Maszczak-Seneczko, Maciej Wiktor, Wojciech Wiertelak, Aleksandra Makowiecka, Mariusz Olczak   +6 more
openaire   +2 more sources