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Serpin-independent anticoagulant activity of a fucosylated chondroitin sulfate
Thrombosis and Haemostasis, 2008SummaryFucosylated chondroitin sulfate is a glycosaminoglycan from sea cucumber composed of a chondroitin sulfate-like core with branches of sulfated fucose. This glycosaminoglycan has high anticoagulant and antithrombotic activities. Its serpin-dependent anticoagulant activity is mostly due to activating thrombin inhibition by heparin cofactor II ...
Bianca F, Glauser +3 more
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Fucosylated chondroitin sulfate as a new oral antithrombotic agent
Thrombosis and Haemostasis, 2006SummaryFucosylated chondroitin sulfate is a potent anticoagulant polysaccharide extracted from sea cucumber. Its anticoagulant activity is attributed to the presence of sulfated fucose branches. We have shown that intravascular injection of fucosylated chondroitin sulfate inhibits thrombus formation in a venous and an arterial shunt model in rats ...
Roberto J C, Fonseca, Paulo A S, Mourão
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Fucosylated chondroitin sulfate diversity in sea cucumbers: A review
Carbohydrate Polymers, 2014Fucosylated chondroitin sulfate (FucCS) is structurally distinct glycosaminoglycans found from the sea cucumber body wall consisted of chondroitin sulfate type backbone with attached sulfated or non-sulfated fucose side chain. Structurally this compound plays an important role in maintaining the body wall integrity and possesses a wide spectrum of ...
Pang Myron +2 more
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Synthesis of trisaccharide repeating unit of fucosylated chondroitin sulfate
Organic & Biomolecular Chemistry, 2019A synthesis of repeating unit of trisaccharide, complete stereoselectivity of glycosylation and flexible synthetic strategy.
Haiqing He +5 more
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Inactivation of Thrombin by a Fucosylated Chondroitin Sulfate from Echinoderm
Thrombosis Research, 2001A polysaccharide extracted from the sea cucumber body wall has the same backbone structure as the mammalian chondroitin sulfate, but some of the glucuronic acid residues display sulfated fucose branches. These branches confer high anticoagulant activity to the polysaccharide.
P A, Mourão +5 more
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Two fucosylated chondroitin sulfates from the sea cucumber Eupentacta fraudatrix
Carbohydrate Polymers, 2017Two fucosylated chondroitin sulfates EF1 and EF2 were isolated from the sea cucumber Eupentacta fraudatrix. Separation of the polysaccharides was performed using anion-exchange chromatography on DEAE-Sephacel by elution of 0.75M and 1.0M NaCl solutions. The structures of biopolymers were determined by chemical and NMR spectroscopic methods.
Nadezhda E, Ustyuzhanina +4 more
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Anticoagulant activity of fucosylated chondroitin sulfate isolated from Cucumaria syracusana
Process Biochemistry, 2020Abstract Fucosylated chondroitin sulfate (FCScs) isolated from sea cucumber Cucumaria syracusana was characterized by Fourier Transform InfraRed spectroscopy (FT-IR), Nuclear Magnetic Resonance (NMR) spectroscopy and high performance size exclusion chromatograph, a multi-angle laser light scattering detector, a viscometer and a differential ...
Latifa Chahed +8 more
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Chemistry – A European Journal, 2016
AbstractFucosylated chondroitin sulfate (fCS)—a glycosaminoglycan (GAG) found in sea cucumbers—has recently attracted much attention owing to its biological properties. In particular, a low molecular mass fCS polysaccharide has very recently been suggested as a strong candidate for the development of an antithrombotic drug that would be safer and more ...
Antonio Laezza +7 more
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AbstractFucosylated chondroitin sulfate (fCS)—a glycosaminoglycan (GAG) found in sea cucumbers—has recently attracted much attention owing to its biological properties. In particular, a low molecular mass fCS polysaccharide has very recently been suggested as a strong candidate for the development of an antithrombotic drug that would be safer and more ...
Antonio Laezza +7 more
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Increased calcium affinity of a fucosylated chondroitin sulfate from sea cucumber
Carbohydrate Research, 1994Calcium binding and charge distribution on a fucosylated chondroitin sulfate and a standard chondroitin 6-sulfate have been studied using a metallochromic indicator and conductimetric titrations. The fucosylated chondroitin sulfate has a approximately 5-fold greater affinity for calcium ions than the standard chondroitin 6-sulfate.
Ruggiero, J., Vieira, R. P., Mourao, PAS
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Journal of Agricultural and Food Chemistry, 2022
Growing evidence for the importance of the gut-brain axis in Parkinson's disease (PD) has attracted researchers' interest in the possible application of microbiota-based treatment approaches. Using a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced mouse model, we looked into the prospect of treating PD with fucosylated chondroitin sulfate ...
Yimeng Liu +10 more
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Growing evidence for the importance of the gut-brain axis in Parkinson's disease (PD) has attracted researchers' interest in the possible application of microbiota-based treatment approaches. Using a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced mouse model, we looked into the prospect of treating PD with fucosylated chondroitin sulfate ...
Yimeng Liu +10 more
openaire +2 more sources