Results 1 to 10 of about 15,330 (252)

Structural insights into mechanism and specificity of the plant protein O-fucosyltransferase SPINDLY

Nature Communications, 2022
Arabidopsis SPINDLY (SPY) is a nucleocytoplasmic protein O-fucosyltransferase. Here, the authors present a crystal structure of Arabidopsis SPY/GDP complex, reveal SPY’s substrate recognition and enzyme mechanism, and provide insights into the glycan ...
Li Zhu, Xiting Wei, Jianming Cong, Jing Zou, Lihao Wan, Shutong Xu   +5 more
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Genetic Manipulation of Human Intestinal Enteroids Demonstrates the Necessity of a Functional Fucosyltransferase 2 Gene for Secretor-Dependent Human Norovirus Infection [PDF]

mBio, 2020
Several studies have demonstrated that secretor status is associated with susceptibility to human norovirus (HuNoV) infection; however, previous reports found that FUT2 expression is not sufficient to allow infection with HuNoV in a variety of continuous
Kei Haga, Khalil Ettayebi, Victoria R. Tenge, Umesh C. Karandikar, Miranda A. Lewis, Shih‐Ching Lin, Frederick H. Neill, B. Vijayalakshmi Ayyar, Xi‐Lei Zeng, Göran Larson, Sasirekha Ramani, Robert L. Atmar, Mary K. Estes   +12 more
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Improved production of 2′-fucosyllactose in engineered Saccharomyces cerevisiae expressing a putative α-1, 2-fucosyltransferase from Bacillus cereus

Microbial Cell Factories, 2021
Background 2′-fucosyllactose (2′-FL) is one of the most abundant oligosaccharides in human milk. It constitutes an authorized functional additive to improve infant nutrition and health in manufactured infant formulations.
Mingyuan Xu, Xiangfeng Meng, Weixin Zhang, Yu Shen, Weifeng Liu   +4 more
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Fucosyltransferase 2: A Genetic Risk Factor for Intestinal Diseases

Frontiers in Microbiology, 2022
The fucosyltransferase 2 gene (FUT2) mediates the synthesis of histoblood group antigens (HBGA) that occur in vivo from multiple organs, particularly on the surface of intestinal epithelial cells and body fluids.
Mingyang Hu, Xiyun Zhang, Jinze Li, Luotong Chen, Xiaolin He, Tingting Sui   +5 more
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Structural basis for substrate specificity and catalysis of α1,6-fucosyltransferase

Nature Communications, 2020
Core-fucosylation of the N-glycan core is an essential biological modification and the α1,6- fucosyltransferase FUT8 is the only enzyme in humans that catalyses this modification through the addition of an α-1,6-linked fucose to N-glycans.
Ana García-García, Laura Ceballos-Laita, Sonia Serna, Raik Artschwager, Niels C. Reichardt, Francisco Corzana, Ramon Hurtado-Guerrero   +6 more
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Glycosyltransferases: glycoengineers in human milk oligosaccharide synthesis and manufacturing [PDF]

Frontiers in Molecular Biosciences
Human milk oligosaccharides (HMOs) are a diverse group of complex carbohydrates that play crucial roles in infant health, promoting a beneficial gut microbiota, modulating immune responses, and protecting against pathogens.
Alanna S. Slater, Alanna S. Slater, Andrew G. McDonald, Rita M. Hickey, Gavin P. Davey   +4 more
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Pofut1 point-mutations that disrupt O-fucosyltransferase activity destabilize the protein and abolish Notch1 signaling during mouse somitogenesis. [PDF]

PLoS ONE, 2017
The segmental pattern of the vertebrate body is established via the periodic formation of somites from the presomitic mesoderm (PSM). This periodical process is controlled by the cyclic and synchronized activation of Notch signaling in the PSM. Protein O-
Rieko Ajima, Emiko Suzuki, Yumiko Saga
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Fucosyltransferase 4 shapes oncogenic glycoproteome to drive metastasis of lung adenocarcinoma

EBioMedicine, 2020
Background: Aberrant fucosylation plays a critical role in lung cancer progression. Nevertheless, the key fucosyltransferase with prognostic significance in lung cancer patients, the enzyme's intracellular targets, and complex molecular mechanisms ...
Hsuan-Hsuan Lu, Shu-Yung Lin, Rueyhung Roc Weng, Yi-Hsiu Juan, Yen-Wei Chen, Hsin-Han Hou, Zheng-Ci Hung, Giovanni Audrey Oswita, Yi-Jhen Huang, Shih-Yun Guu, Kay-Hooi Khoo, Jin-Yuan Shih, Chong-Jen Yu, Hsing-Chen Tsai   +13 more
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Correlation Of Fut2 And Fut3 Gene Polymorphisms With Inflammatory Bowel Disease In Guangxi Zhuang Population [PDF]

International Journal of General Medicine
Xiaodan Lv,1,* Zhou Huang,2,* Shiquan Li,3 Xiaofang Xu,3 Deyi Chen,3 Lichun Han,3 Yu He,1 Shan Huang,1 Huiling Wu,1 Yunwei Qi,1 Liqiang Wei,1 Min Chen,1 Lingling Zhan,1 Xiaoping Lv3 1Department of Clinical Laboratory, the First Affiliated ...
Lv X, Huang Z, Li S, Xu X, Chen D, Han L, He Y, Huang S, Wu H, Qi Y, Wei L, Chen M, Zhan L, Lv X   +13 more
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Mammalian α-1,6-Fucosyltransferase (FUT8) Is the Sole Enzyme Responsible for the N-Acetylglucosaminyltransferase I-independent Core Fucosylation of High-mannose N-Glycans [PDF]

Journal of Biological Chemistry, 2016
Understanding the biosynthetic pathway of protein glycosylation in various expression cell lines is important for controlling and modulating the glycosylation profiles of recombinant glycoproteins.
Qiang Yang, Lai‐Xi Wang
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